Z. Xu

This paper develops a mathematical model to predict SARS-CoV-2 evolutionary trends, finding that virulence may decrease while transmissibility increases, with virulence remaining stable.

The paper uses AI-generated virtual libraries to explore RNA-specific chemical space and finds they replicate trends seen in experimentally validated RNA binders.

CoVac501, a self-adjuvanting peptide vaccine with TLR7 agonists, induces strong neutralizing antibodies and T cell responses in non-human primates against SARS-CoV-2.

The paper identifies keystone species in synthetic microbial biofilm communities that influence their productivity through metabolic facilitation or competition.

This study uses optical coherence tomography to track the morphological and functional development of human heart organoids over time.

This study analyzes the genomic and phylogeographic dynamics of B. pertussis in Australia, revealing lineage expansion, selective sweeps, and spatial spread patterns linked to vaccination and transmission.

This study optimizes excitation wavelength and emission window for SPNs to improve imaging quality, showing L1057 NPs achieve superior resolution and signal-to-background ratio in the NIR-IIb window.

The paper determines the structure of the Kv2.1 T1 domain, revealing it forms a pentamer instead of the typical tetramer, with implications for its unique functional versatility.

This study develops engineered small extracellular vesicles targeting FGL1 and PD-L1 to suppress immune rejection in transplantation by inhibiting T cell activation and improving graft survival.

This study identifies AI-2 as a quorum sensing signal that inhibits sporulation in Bacillus velezensis SQR9 by interacting with RapC and ComA, revealing a population-level regulatory mechanism.

This study identifies a TM4SF1-positive cancer subpopulation in bladder cancer that drives intratumor heterogeneity and is associated with poor prognosis.

This study identifies OsMADS58's role in stabilizing gene regulatory circuits during rice stamen development using CRISPR knockout and transcriptomic analysis.

This study shows that modifying the Spo0A gene in B. velezensis SQR9 improves plant growth promotion when combined with FZB42 in two-member consortia.

This study identifies a novel cannibalism mechanism in Bacillus velezensis SQR9 mediated by bacillunoic acids, enhancing biofilm formation and interspecies competition through a two-component regulatory system.

This study shows that adipocyte-specific KLF14 modulation in mice has sex-dependent effects on adiposity and lipid metabolism, with female mice showing increased fat mass and altered lipid storage when KLF14 is deficient.

The paper analyzes Antibiotic_NAT family enzymes to understand resistance diversification, finding environmental variants confer broad-spectrum resistance and likely ancestral relationships to clinical genes.

This study identifies PlMYB308 as a key regulator of flower senescence in herbaceous peony by modulating hormone levels and anthocyanin biosynthesis.

The paper identifies noncovalent, reversible inhibitors of HhC cholesterolysis, challenging the irreversibility rule for protein autoprocessing inhibition.

This paper enhances antibody therapy for breast cancer bone metastasis by engineering antibodies with bone-homing peptides, improving their bone tumor targeting and therapeutic efficacy.

The paper investigates the relationship between antagonism and phylogeny in Bacillus by analyzing biosynthetic gene clusters (BGCs) and finds a positive correlation between BGC distance and phylogenetic distance.

This study develops a single-dose rAAV5-based vaccine that provides long-term immunity against SARS-CoV-2 and its variants with high neutralizing antibody titers and safety.

Acoustic light-sheet microscopy overcomes the trade-off between field-of-view and axial resolution in light-sheet microscopy by guiding light through acoustic pulses.

This paper develops a CRISPRi/a approach to reactivate FOXP3 and silence XIST from XCI in human breast cancer cells, showing enhanced epigenetic changes and therapeutic potential.

This paper develops a rat model for oxytocin-induced labor and evaluates its effects on maternal and neonatal outcomes, finding no evidence of oxidative stress in the newborn brain.

This study shows that Bacillus velezensis SQR9 uses a type VII secretion system to acquire iron from plant roots, enhancing its colonization.

The paper introduces a database that compiles antibody responses and clinical data from COVID-19 patients for analysis and visualization.

This study establishes three clinical breakpoint values for danofloxacin against Glaesserella parasuis using epidemiological, pharmacodynamic, and clinical data.

This study examines how social network centrality relates to parasite infection intensity in Japanese macaques and shows that sampling bias can obscure network effects.

This study identifies pS273R as an ASFV protease that inhibits the cGAS-STING pathway by targeting IKKε, revealing a new immune evasion mechanism.

This study identifies metabolic interactions between Bacillus velezensis and Pseudomonas stutzeri in the cucumber rhizosphere that enhance plant growth and salt stress tolerance.