Z. Xu

This paper develops a deep learning model to predict ERG:TMPRSS2 fusion status in prostate cancer from whole slide images and identifies associated morphological features.

This paper demonstrates that planarians can navigate to a previously recognized location in a new maze, indicating they have spatial localization ability.

This study identifies two benzophenanthridine derivatives with potent anti-Mtb activity, effective against multidrug-resistant strains and comparable to rifampicin.

This paper introduces a vortex ultrasound technique for endovascular sonothrombolysis that significantly improves clot lysis rates in cerebral venous sinus thrombosis.

This study uses deep learning on plasma extracellular vesicle RNA to predict cancer subtypes, monitor treatment effects, and identify gene fusions and neoepitopes without tissue sampling.

This study shows that aquatic planarians can sense humidity and use this ability to find water during drought by diving behavior.

This study shows that B. velezensis SQR9 alters rhizosphere microbial community structure and promotes cooperation among Bacillus species, enhancing plant growth.

This study identifies conserved cold-responsive regulators and their regulatory networks across three rosid species, revealing a hierarchical control involving circadian components.

DeepAIR integrates sequence and 3D structure features of adaptive immune receptors to predict binding affinity and reactivity, outperforming existing methods on multiple tasks.

This study identifies TRAF6 as a regulator of PD-L1 expression in melanoma through YAP1-TFCP2 signaling, showing TRAF6 inhibition enhances anti-tumor immunity.

This study identifies a microglia-CD4+ T cell interaction that enhances anti-glioblastoma immunity through IFN-gamma-mediated tumor surveillance and phagocytosis.

This study shows that APOA1 and HDL reduce LDL transcytosis by competing with LDL for SR-B1 binding, thereby limiting atherosclerosis.

The paper uses electric fields to induce migration in human keratinocyte sheets and develops an in silico model showing how directional cues propagate to drive coherent collective migration.

This study identifies H2BFWT's role in spermatogenesis by showing its impact on nucleosome stability and gene expression through structural and functional analyses.

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

This study identifies infection-enhancing antibodies in COVID-19 patients and healthy donors, finding they are more frequent in patients but also present in healthy individuals.

This paper introduces a deep learning model to detect homologous recombination deficiency from shallow whole genome sequencing data, achieving high accuracy comparable to deeper sequencing methods.

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

This study identifies OsAIM1 as essential for high basal SA levels in rice, which regulate stomatal aperture and shoot temperature.

This paper introduces an algorithm called cryoRL that uses reinforcement learning to optimize cryo-EM data collection, outperforming human operators in efficiency and image quality.

This paper designs novel protein interactions using geometric deep learning to generate surface fingerprints, achieving nanomolar affinity for four targets through computational and experimental methods.

This study shows that even after correcting hyperglycemia, persistent lipotoxicity from arachidonic acid and lysophosphatidylcholine impairs β-cell function in diet-induced obese mice.

The paper examines dynamic changes in nucleolar structure and nucleoli-centromere interactions during development and in cancer, finding that these changes correlate with cell differentiation and malignancy.

This study identifies a toxin-mediated policing system in Bacillus that punishes phenotypic cheaters, enhancing population fitness in plant rhizosphere and under stress.

The paper determines the cryo-EM structure of LARGE1 and shows it functions as a dimer to processively polymerize matriglycan on dystroglycan using alternating active sites.

This study evaluates the use of the housekeeping gene gyrA as a molecular marker for Bacillus species diversity and ecology, showing improved resolution compared to 16S rRNA.

This study shows HTL/KAI2 signalling in Arabidopsis can substitute for light in germination, bypassing the need for light through interactions with PIF1/PIL5-regulated hormone pathways.

This study shows that music increases protein content and photosynthetic efficiency in duckweed and activates Glu and Ca signaling, with transcriptomic changes linked to metabolic pathways.

This study improves plant growth-promotion by engineering specialized bacterial mutants within a single species and assembling them into consortia that enhance root colonization and disease resistance.

This study identifies and characterizes DacM, a diadenylate cyclase in Mycoplasma ovipneumoniae that produces c-di-AMP, and presents its crystal structures to inform drug design.