Caroline Hayward

The paper identifies KRAB-ZFP genes' influence on CpG-site methylation and links these methylation patterns to disease phenotypes like rheumatoid arthritis and HIV infection.

The paper develops epigenetic scores (EpiScores) for plasma proteins to predict disease risk, finding 137 associations with incident morbidities independent of known factors.

SNHap-RHM jointly maps common and rare genetic variation affecting complex traits by combining SNP and haplotype-based genomic relationship matrices, identifying significant genomic regions for height and MDD.

The paper identifies genetic and epigenetic factors influencing plasma protein levels linked to Alzheimer's disease, finding novel associations with TREM2 and TBCA.

This study identifies modifiable parent-of-origin effects on DNA methylation by analyzing genetic and environmental factors in a large cohort.

This study identifies genetic loci associated with SARS-CoV-2 susceptibility and disease severity using GWAS and colocalization, and links them to eQTLs in various tissues.

This study uses genome-wide methylation data to assess the impact of smoking and gene-smoking interactions on obesity-related traits, showing improved variance explanation compared to traditional methods.

The paper uses symptom-based case predictions to conduct a GWAS on COVID-19, finding new genetic susceptibility insights and suggesting different genetic architectures for severity and susceptibility.

This study identifies 592 genetic loci associated with 184 plasma proteins in 26,494 individuals and finds causal relationships between protein levels and disease.

In 159,701 siblings from 17 cohorts, population GWAS overstate direct effects on height, education, smoking, cognition, depressive symptoms and age at first birth; clinical traits mostly agree across models.

CREST identifies pedigree relationships using IBD sharing and sex-specific genetic maps, achieving high accuracy in simulated and real datasets.

This paper introduces a cutoff selection algorithm for correlation networks that uses prior knowledge to improve network reconstruction, showing better performance than statistical cutoffs across multiple datasets.

This paper conducts a genome-wide association study of suicide death and shows polygenic scores predict suicide case-control status and related psychiatric traits.

This study identifies 48 genetic variants associated with handedness using a large GWAS, highlighting polygenic nature and genetic links to neuropsychiatric traits.

This study identifies epigenome-wide DNA methylation differences between APOE ε4 and ε2 carriers in whole blood, implicating lipid-related genes.

This study shows that DNAm GrimAge predicts disease incidence and prevalence better than other epigenetic clocks in a large cohort.

The paper develops an epigenetic CRP score to assess chronic inflammation and its link to cognitive ability, finding it more consistently associated with cognition than serum CRP across two cohorts.

The paper evaluates normalization methods for glycomics data by assessing how well they enable accurate reconstruction of known glycosylation pathway reactions using Gaussian Graphical Models.

This study identifies 137 genome-wide significant loci associated with DNA methylation biomarkers of ageing using DNAm and SNP data from over 41,000 individuals.

The paper identifies SNPs with sex-specific effects on lung function traits using UK Biobank data, finding a significant interaction at rs7697189 near HHIP.

The paper identifies pQTLs for cardiovascular proteins and uses them to evaluate drug targets and suggest new candidates for precision medicine.

This study identifies 3 genetic loci associated with neck or shoulder pain using UK Biobank data, with partial replication in Generation Scotland.

This study finds that subthreshold psychosis symptoms in a population-based cohort are associated with genetic risks for schizophrenia, ADHD, autism, and neuroticism, with notable sex differences.

The paper identifies DNA methylation signatures associated with dementia risk factors in blood samples from individuals without Alzheimer's disease.

This study identifies DNA methylation loci associated with age-by-sex interactions in a cohort of 2,586 individuals, finding most significant loci are X-linked and linked to disease-related genes.

This study identifies genetic loci associated with household income and links them to biological pathways and cognitive ability, showing genetic differences between income and education.

The paper examines genetic and shared couple environmental factors influencing smoking and alcohol use in the UK population using family and couple data.

This paper conducts GWAS on two epigenetic age acceleration measures, identifying genetic variants and genes associated with each, and highlighting differences in their genetic architectures.

This study identifies 210 genetic loci associated with the PR interval through multi-ancestry GWAS, highlighting their role in cardiac conduction and cardiovascular disease.