wet-lab / biochemical assay

This study evaluates PSMA-targeted CAR-Ms in preclinical models, showing tumor regression and safety in xenograft mice.

The paper develops and validates the tviblindi algorithm to identify branching developmental trajectories in human B cell development using mass cytometry data.

This study shows that Piezo1 on preosteoclasts reduces osteoclast formation and bone resorption in periodontitis via the PP2A-Akt pathway.

The paper describes a method to temporarily modulate phage DNA modifications using NgTET, enabling efficient Cas-mediated mutagenesis and functional analysis of phage epigenome.

This study uses agent-based modeling to show how morphology and motility differences between bacterial species affect their spatial organization and collective behavior in mixed populations.

The paper shows that TET8 in the apoplast correlates with leaf senescence and that tet3tet8 mutants delay senescence, suggesting TET8 and PEN1-associated EVs have opposing roles in leaf aging.

The paper shows that mutant p53R175H in ovarian cancer precursor cells protects them from cisplatin by requiring SLC6A6 taurine transporter expression.

This study identifies a novel non-canonical role for CSA in maintaining nuclear envelope integrity, linking DNA repair defects to progeroid phenotypes through NE dysfunction and immune activation.

This study shows TPM1 deficiency promotes cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis in both human and mouse models.

The paper biochemically characterizes KpAspE, a Group 5 septin from Knufia petricola, showing it recapitulates functions of canonical septin hetero-octamers in vitro.

The paper shows mosaic-8b nanoparticles induce broader cross-reactive antibodies than homotypic ones, even in pre-vaccinated animals, suggesting potential for improved vaccine design against emerging sarbecoviruses.

This study shows HIRA and PML regulate SASP through interactions with p62/SQSTM1 and the cGAS-STING pathway in senescent cells.

This study uses VaxSkin to analyze the skin's response to mRNA-1273 vaccine, showing targeted immune cell activation and communication.

The paper compares labelling enzymes for proximity labelling experiments using CRISPR-Cas9 knock-ins, showing TurboID's effectiveness in identifying interactors and cargo proteins.

This study generates human cerebellar organoids to model medulloblastoma subgroups G3 and G4, showing their ability to sustain tumor growth and respond to anti-tumour compounds.

This study shows that GLP-1 receptor activation in the olfactory bulb enhances insulin secretion via a sympathetic pathway involving the paraventricular nucleus.

This study shows that ER-phagy drives age-related ER remodeling and lifespan, revealing it as a protective mechanism in aging.

This study identifies Mfn2's role in promoting NCLX-mediated Ca2+ release from mitochondria, linking mitochondrial ROS to mitophagy via Ca2+ signaling.

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

This study shows BiP directly interacts with Ire1 oligomers to regulate its activation, controlling ER stress response by modulating Ire1-LD oligomerization.

This study shows caspase-2 is essential for proliferation and self-renewal of NPM1-mutated AML cells, suggesting it as a potential therapeutic target.

This study shows that HCM cardiomyocytes have slower conduction and increased repolarization dispersion, which contribute to arrhythmia in an iPSC model.

This study identifies EOMES+Tr1-like regulatory T-cells in MS that produce IL-10 and are activated by EBV, suggesting their impaired function contributes to immune escape.

This study shows that glutathione overproduction enables lymphoma initiating cells to survive in soft gels and that targeting glutathione production can inhibit lymphoma growth, with a sex-dependent effect observed in mice.

This study identifies Gpi, a PLE-encoded inhibitor of ICP1's DNA packaging motor, and shows how PLEs use multiple strategies to overcome inhibition and promote their own spread.

This study identifies MARK2/3 as essential kinases for YAP/TAZ function in cancer and shows their inhibition can restore Hippo pathway tumor suppression.

This study shows that cardiolipin remodeling is essential for maintaining inner mitochondrial membrane structure in yeast under low oxygen conditions and identifies Ddl1p as a regulator of CL levels.

This study identifies specific iNKT cell subsets in mice and humans with enhanced antitumor activity, suggesting potential improvements for adoptive cell therapies.

The paper identifies a missing-link fold, DZBB, that connects RNA polymerase and ribosomal proteins, showing rapid diversification from a common ancestor.

This study identifies GIGYF1 as a repressor of mRNA translation by disrupting the eIF3-eIF4G1 interaction, enhancing host immune response by derepressing Ifnb1 mRNA.