proteomics

The FDA-approved CDK4/6 inhibitor Abemaciclib is a potent agonist of the β-arrestin-biased atypical chemokine receptor ACKR3

This paper identifies abemaciclib, an FDA-approved CDK4/6 inhibitor, as a potent agonist of ACKR3, an atypical chemokine receptor, revealing its ability to modulate chemokine availability and receptor activity.

Large-scale AI-guided discovery of antifreeze peptides reveals functional tandem-repeat architectures

This study uses AI to discover antifreeze peptides, finding that tandem-repeat sequences are functional and effective in inhibiting ice recrystallization.

Developing synthetic auxin-based trans-kingdom signaling

This paper develops a tunable auxin-based trans-kingdom signaling system that enables cross-species communication by engineering auxin biosynthesis and response mechanisms in different organisms.

KDRD: assessing discovery replicability based on summary association statistics from a single study

KDRD estimates replicability of associations using summary statistics from a single study, showing moderate to high replicability for 33 of 45 brain-related traits in proteomics analyses.

Intestinal molecular siphoning by engineered bacterial spores for non-systemic treatment of nicotine addiction

This paper develops a live bacterial system to reduce nicotine levels in blood and brain by enzymatic degradation in the gut, showing potential for non-systemic treatment of nicotine addiction.

A biomimetic SPARC platform coupling adaptor recruitment and BRS-Lck condensation for enhanced NK/T cell combination therapy

N-GLYcanyzer monitoring of a microperfusion process reveals critical parameters' impact on Trastuzumab biosimilar N-glycoform time evolution

The paper uses N-GLYcanyzer to monitor Trastuzumab biosimilar N-glycoform changes in a microperfusion process, identifying key parameters affecting glycoform evolution.

Bispecific VSV-G Engagers: A Platform for Cell-Type-Specific Delivery of Viral Vectors

This paper develops bispecific VSV-G engagers to enable cell-type-specific delivery of viral vectors, demonstrating effectiveness in targeting tumor cells and generating CAR T cells.

Structure-Based Discovery of GTP-Enhanced Rab10 Modulators and Their Effects on Alzheimer Disease-Relevant Cellular Phenotypes

The paper identifies Rab10 modulators through virtual screening and evaluates their effects on Alzheimer's disease-related cellular phenotypes.

HLAResolver: A statistical framework for resolving HLA ambiguity in T-cell response data

HLAResolver improves HLA resolution in T-cell response data by integrating MIRA responses with NetMHCpan predictions, achieving higher sensitivity and fewer candidate HLAs.

Molecular basis of Cyclin B1-CDK1 recruitment by MAD1

The paper identifies a non-canonical helical binding motif in MAD1 that specifically interacts with Cyclin B1 to recruit CDK1 to the SAC, revealing a mechanism for B-type cyclin recognition.

Amyloid/RNA Condensates with Germ Granule Characteristics Are Present in Rat Epididymal Spermatozoa and Exhibit Prion-Like Propagation Activity

The paper identifies germ granule-like amyloid/RNA condensates in rat epididymal spermatozoa that exhibit prion-like propagation activity, suggesting a non-Mendelian mechanism for transmitting environmental information to offspring.

NRT2.2 is essential for nitrate uptake and carbon-nitrogen balance in Nannochloropsis oceanica

This study identifies NRT2.2 as the primary nitrate transporter in Nannochloropsis oceanica and shows its critical role in nitrate uptake and carbon-nitrogen balance.

CO2-concentrating nanoparticles drive progressive photosynthetic and cell-wall remodelling in Arabidopsis thaliana cells

The paper shows that CO2-concentrating nanoparticles modify photosynthesis and cell wall structure in Arabidopsis cells over time.

Species-specific WNT requirements shape somite morphogenesis in mammalian embryo models

This study compares somitogenesis across human, pig, sheep, and cow stem cell-derived embryo models, revealing species-specific WNT signaling and extracellular matrix requirements for axial segmentation.

Mapping the sequence determinants of constitutive activity in GPCRs

The paper measures basal activity across the human GPCR family on a single scale and identifies key residues that influence constitutive signaling.

Inflammatory proteostasis reprogramming creates a lysosomal bottleneck for microglial aggregate clearance

This study shows that inflammatory activation impairs microglial degradation of protein aggregates by creating a lysosomal bottleneck, without affecting their uptake.

LplA-mediated rescue of lethal myopathy and cardiomyopathy in mitochondrial lipoylation-deficient mammalian caused by Lipt1

This study uses AAV-delivered LplA to rescue lethal mitochondrial lipoylation defects in Lipt1-deficient mice, improving survival, motor function, and cardiac health.

Latent Transforming Growth Factor Binding Protein-2 promotes microfibrillar TGF-β bioavailability to drive pathologic fibrosis in remote regions of infarcted hearts

This study shows that LTBP2 promotes fibrosis in remote myocardium after MI by sequestering latent TGF-β, and its deletion reduces fibrosis and improves cardiac function.

Sodium arsenite requires redox sensitization to cause developmental dopaminergic neurotoxicity in Caenorhabditis elegans

This study shows that sodium arsenite requires additional mitochondrial or redox stress to cause dopaminergic neurotoxicity in C. elegans, but not fluoroacetic acid.

An LRH-1 agonist reverses hepatic metabolic dysfunction in obesity

This study develops an LRH-1 agonist that improves insulin sensitivity and reduces liver fat in obese mice, revealing peroxisomal lipid metabolism as a key pathway.

Synthetic reaction-diffusion patterning in mammalian cells

This study designs synthetic reaction-diffusion circuits in mammalian cells to generate spatial patterns with controllable spatial scales.

Serum Calprotectin as predictor of Rheumatoid Arthritis disease severity and Mortality

This study evaluates serum calprotectin as a biomarker for disease activity, severity, cardiovascular risk, and mortality in inflammatory rheumatic diseases, finding it to be a better predictor than CRP in certain contexts.

Predicting seabird-vessel interactions from bird-borne data alone

This paper develops a method to predict seabird-vessel interactions using only seabird telemetry data, showing high accuracy but limitations in distinguishing fishing from nonfishing vessels.

NTAD: A longitudinal neuroimaging dataset of Alzheimer's disease pathology

The paper introduces a longitudinal neuroimaging dataset of Alzheimer's disease pathology, including multimodal data from patients and controls, to identify and validate novel biomarkers.

Resonant Recognition Model analysis of cGAS: conserved spectral frequencies and a divergent naked mole-rat phase signature

This paper uses the Resonant Recognition Model to analyze cGAS and FANCI sequences across species, identifying conserved spectral features and divergent phase signatures in naked mole-rats.

Serotype specific anti-capsular polysaccharide IgG associated with colonizing and invasive group B streptococcus in pregnant woman-newborn dyads

The paper quantifies serotype-specific anti-capsular polysaccharide IgG in pregnant women and newborns to assess protection against invasive group B streptococcus (GBS) disease.

The IFN-γ-inducible GTPase IIGP1 regulates mitochondrial remodeling and immunometabolic reprogramming during inflammatory macrophage polarization

Large-scale forward genetics reveals genetically separable components of plant cell proliferative capacity

The paper uses forward genetics and phenotyping to identify genetic factors affecting plant cell proliferative capacity, finding distinct genetic components for different growth traits.

Proteomic signatures of cold adaptation and sponge host adaptation in marine Archaea

The paper evaluates amino acid compositional indices for detecting cold adaptation in marine Archaea and finds no evidence of cold adaptation but identifies proteomic signatures linked to sponge host adaptation.