development & morphogenesis

Signals beneath the ectoderm: Mesodermal FGF signaling keeps the dorsally closing epithelium in shape

The paper shows that mesodermal FGF signaling stabilizes the ectoderm during dorsal closure in Drosophila, revealing a reciprocal influence between mesoderm and ectoderm.

First-in-class -PET radiotracers for GPR39: A platform for noninvasive target engagement imaging in vivo

This paper introduces [18F]GPR39 2.1, a PET radiotracer for noninvasive imaging of GPR39, showing high specificity and sensitivity in vivo.

Variable errors suppress implicit motor adaptation among older adults

This study shows that older adults exhibit enhanced implicit motor adaptation only with consistent errors, not variable ones, suggesting error consistency is key for age-related adaptation.

SEC16A/MAG5-mediated ER export shapes ABA receptor homeostasis

The paper identifies SEC16A/MAG5 as essential for ABA receptor homeostasis by mediating ER export and trafficking, impacting ABA signaling without affecting ABA levels.

Cell cycle progression and stalked cell morphogenesis in Caulobacter crescentus are regulated independently by the flagellum

This study identifies fss genes that regulate stalked cell morphogenesis and cell cycle progression independently of the flagellum in Caulobacter crescentus.

Parallel Trajectories in the Evolution of C-class MADS-box Genes in Flowering Plants and Conifers

This study identifies two AG gene duplications in conifers and characterizes their subfunctionalized expression patterns, revealing evolutionary mechanisms for reproductive trait diversity in Cupressaceae and convergent evolution across conifers and flowering plants.

Sensory experience-induced plasticity of somatostatin interneurons occurs through two-pore potassium (K2P) channels

The paper investigates experience-dependent plasticity in somatostatin interneurons and identifies two-pore potassium (K2P) channels as a mechanism underlying this plasticity.

Embryonic integrin signaling establishes a program of differential cell elongation in a growing proprioceptive organ

This study identifies integrin signaling as a mechanism that restricts ligament cell elongation during embryonic development, enabling cap cell elongation in the ChO.

Environmental Frass Remodels the Larval Gut Microbiome to Enable Black Soldier Fly (Hermetia illucens) Bioconversion of Livestock Manure

This study shows that wild frass enhances BSFL growth on rabbit manure by introducing lignocellulose-degrading microbes, which are lost in captive-reared frass.

Dynamic mechanical sorting biases niche occupancy and lineage outcome during development of bilayered glandular epithelia

The paper shows that mechanical sorting, driven by adhesion and contractility differences, maintains basal-luminal compartmentalization and influences lineage outcomes in glandular epithelia.

Overlapping enhancer activity robustly regulates rax expression during ocular development in zebrafish

This study identifies five novel ocular enhancers in zebrafish that regulate rax expression during eye development and shows their robustness to perturbations.

IL4Ra Controls The Medullary Dwell Time Of Mature Thymocytes By Scheduling Their Release From The Thymus

This study shows that IL4Ra signaling in SP thymocytes prolongs their medullary dwell time, enhancing their maturation and functional capabilities.

Unbiased lineage tracing across the adipose organ decouples developmental origin from anatomical and transcriptomic identities

This study uses CRISPR-mediated lineage tracing to show that adipose depot identity is shaped by anatomical niche rather than embryonic lineage.

Targeting distinct neuronal populations with AAV vectors reveals neurogenesis-associated anxiolytic effects of JNK inhibition

This study uses AAV vectors to target specific neuronal populations and shows that JNK inhibition has distinct anxiolytic effects depending on the targeted cells.

Thermosensory pathway makes a U-turn to respond to heat

The paper shows that heat stress reverses the growth-promoting thermomorphogenesis pathway in Arabidopsis by suppressing auxin and PIF4 in cotyledons, revealing an active molecular mechanism.

Robust planar morphogenesis in leaf-like organs requires callose-dependent coordination of division and growth

This study shows that callose-dependent coordination between cell division and growth is essential for planar morphogenesis in moss phyllids.

EGF and EREG regulate early oncoprotein-mediated tissue transformation in intestinal organoids.

The paper investigates how EGF and EREG influence early oncogenic transformation in intestinal organoids by altering crypt and villus development.

A Neurocompliant Ionic Conductive Hydrogel Orchestrates Glial and Vascular Remodeling to Mitigate Traumatic Brain Injury

This paper develops a conductive hydrogel that reduces glial and vascular damage in traumatic brain injury models.

Higher stomatal density and smaller stomatal size associate with higher grain yield in winter wheat

This study links higher stomatal density and smaller stomatal size in winter wheat flag leaves to increased grain yield under field conditions.

SPACE-Tag Enables High-Throughput Spatial Chromatin Profiling With CUT&Tag

The paper introduces SPACE-Tag, a spatial CUT&Tag method for chromatin profiling, and applies it to the mouse brain to reveal age-related chromatin and transcriptome changes.

Magnetic organelle gene clusters enable bacterial growth and ATP homeostasis under oxidizing conditions

This study shows that gene clusters for magnetite formation in bacteria confer resistance to hydrogen peroxide, supporting an early origin of magnetotactic bacteria before Earth's oxygenation.

Broad Cognitive and Motivational Enhancement through M4-Selective Muscarinic Modulation

This study evaluates a M4-selective PAM in nonhuman primates, showing broad cognitive and motivational improvements without adverse side effects.

Neurons entrain and shape an intrinsic arteriole rhythm that distributes blood across the cortical mantle

The paper shows neurons entrain an intrinsic arteriole rhythm, shaping blood distribution and vascular responses through frequency-dependent mechanisms.

Starve, stress, and mate: Activation of the CCAAT-Binding complex overrides sterility of mating-type heterozygous Candida albicans

The paper identifies the CCAAT-binding complex (CBC) as a key regulator that overrides genetic sterility in Candida albicans by integrating environmental stress signals to enable mating.

Deprivation of dietary fiber promotes low-grade neuroinflammation and anxiety-like behavior in mice

This study shows that depriving mice of fermentable dietary fiber leads to low-grade neuroinflammation and anxiety-like behavior, which are reversed by fiber supplementation.

An expansive internal chemosensory system in the insect abdomen implicates Gustatory Receptors in diverse aspects of interoception

This study identifies an internal chemosensory system in Drosophila melanogaster's abdomen using Gustatory Receptors, revealing new roles in interoception beyond traditional feeding behaviors.

Distinct lifespan trajectories of cortical intrinsic timescales and neural oscillations

The paper examines lifespan changes in neural temporal dynamics using resting-state MEG data, finding distinct trajectories for cortical intrinsic timescales and alpha oscillations.

Historical contingency is revealed by trade-offs upon sequential adaptation to different infection routes

This study shows that past adaptation to systemic infection affects the speed and mechanism of adaptation to oral infection in Drosophila, with sex-specific outcomes and trade-offs.

A multipotent mouse distal airway secretory cell population that contributes to both airway and alveolar regeneration

This study identifies a multipotent secretory cell population in mouse distal airways that contributes to both airway and alveolar regeneration after injury.

Regenerative epithelial spike cells instruct immune niche homeostasis in zebrafish fin epidermis

The paper identifies a novel epithelial cell type in zebrafish fins, spike cells, and shows their role in maintaining immune cell niche homeostasis through interactions with mpeg1+ immune cells.