Schizophrenia research and treatment

Unexpected higher resilience to distraction during visual working memory in schizophrenia

This study examines visual working memory and distractibility in schizophrenia, finding that patients show unexpected higher resilience to distraction but worse overall performance.

Longitudinal Trajectory of Early Functional Recovery in Patients with First Episode Psychosis

The paper identifies distinct functional recovery trajectories in first episode psychosis patients using data-driven methods and explores associated risk factors.

Paranoid schizophrenia and methamphetamine-induced paranoia are both characterized by a similar LINE-1 partial methylation profile, which is more pronounced in paranoid schizophrenia.

The paper compares LINE-1 methylation patterns in paranoid schizophrenia and methamphetamine-induced paranoia, finding distinct partial methylation profiles with higher mCuC in schizophrenia.

Functional Connectivity of Corticostriatal Circuitry and Psychosis-Like Experiences in the General Community

The paper examines the relationship between functional connectivity of corticostriatal circuits and subclinical psychosis-like experiences in a community sample.

Schizophrenia-associated genomic copy number variants and subcortical brain volumes in the UK Biobank

The paper examines subcortical brain volume differences between schizophrenia-associated CNV carriers and non-carriers in UK Biobank, finding reduced volumes in some structures and partial mediation by cognitive impairment.

In silico investigation of coding variants potentially affecting the functioning of the glutamatergic N-methyl-D-aspartate receptor in schizophrenia

The paper investigates coding variants in NMDAR and related kinase genes in schizophrenia, finding few disruptive variants and some potential functional impacts in FYN and GRIN genes.

Structural brain alterations in youth with psychosis and bipolar spectrum symptoms

The paper identifies structural brain differences in youth with psychosis spectrum symptoms compared to other groups, highlighting reduced cortical surface area and thalamic volume.

Cerebellar grey matter volume is associated with cognitive function and psychopathology in adolescence

This study uses machine learning to show cerebellar morphology predicts cognitive function and psychopathology in adolescents, with stronger links to prodromal psychotic symptoms.

Individuals with 22q11.2 deletion syndrome show intact prediction but reduced adaptation in responses to repeated sounds: evidence from Bayesian mapping

This study examines neural responses to repeated sounds in individuals with 22q11.2 deletion syndrome, finding reduced adaptation but intact prediction, linked to negative symptom severity.

Disruptions in White Matter Maturation and Mediation of Cognitive Development in Youth on the Psychosis Spectrum

The paper examines age-related white matter microstructure differences in psychosis spectrum youth and finds that fractional anisotropy in the superior longitudinal fasciculus mediates cognitive development in typically developing youth but not in psychosis spectrum youth.

The cortico-striatal circuit regulates sensorimotor gating via Disc1/Huntingtin-mediated Bdnf transport

This study shows that the cortico-striatal circuit regulates sensorimotor gating through Disc1/Huntingtin-mediated Bdnf transport, with lithium restoring deficits in Disc1-LI mice.

Schizophrenia risk conferred by protein-coding de novo mutations

This study examines the contribution of protein-coding de novo mutations to schizophrenia risk using whole-exome sequencing data from parent-offspring trios, finding a modest but polygenic effect.

Impaired expected value computations in schizophrenia are associated with a reduced ability to integrate reward probability and magnitude of recent outcomes.

The paper investigates how schizophrenia affects the integration of reward probability and magnitude, finding that patients rely more on stimulus-response learning than expected value-based learning.

Cost evaluation during decision making in patients at early stages of psychosis

This study shows early psychosis patients jump to conclusions due to perceiving higher information sampling costs, not due to noisy decision making.

Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain

This study identifies and prioritizes gene sets linked to schizophrenia risk using co-expression network analysis in human brain data, highlighting modules associated with diagnosis and polygenic risk scores.

Overly strong priors for socially meaningful visual signals in psychosis proneness

The paper investigates whether overly strong priors for socially meaningful visual signals are associated with psychosis proneness by measuring face and gaze detection in healthy individuals.

Development of the MAM model of schizophrenia in mice: Sex similarities and differences of prefrontal cortical and hippocampal function

This study develops a MAM mouse model of schizophrenia and finds sex-specific cognitive and neurophysiological deficits in male but not female mice.

Connectivity analyses of bioenergetic changes in schizophrenia: Identification of novel treatments

The paper identifies PPAR agonists as potential treatments for schizophrenia by analyzing bioenergetic changes in the DLPFC using bioinformatics and experimental validation.

Paracingulate sulcus morphology and hallucinations in clinical and non-clinical groups

The paper investigates whether shorter paracingulate sulcus length, linked to hallucinations in schizophrenia, is also present in non-clinical individuals with hallucinations.

Parvalbumin loss following chronic sub-anesthetic NMDA antagonist treatment is age-dependent in the hippocampus: Implications for modeling NMDA hypofunction

This study investigates age-dependent changes in parvalbumin (PV) in the hippocampus following chronic sub-anesthetic ketamine treatment in rats, finding significant decreases in young rats and modest increases in adults.

White matter connectivity disruptions in the pre-clinical continuum of psychosis: A connectome study

The paper identifies a widespread white matter connectivity reduction in healthy individuals with more psychotic-like experiences, suggesting a potential biomarker for psychosis risk.

fMRI salience signals in antipsychotic naive first episode psychosis

This study investigates salience processing abnormalities in first episode psychosis patients using fMRI, finding reduced neural signaling in midbrain and cortical regions for various salience types.

Neural correlates of reward anticipation in 2000 children aged 9-10 years: relation to psychotic-like experiences and depressive symptoms

This study examines the relationship between reward anticipation brain activity and psychopathology in children, finding a single significant association between right parsorbitalis activation and psychotic-like experiences.

White matter aberrations and age-related trajectories in patients with schizophrenia and bipolar disorder revealed by diffusion tensor imaging

The paper uses diffusion tensor imaging to identify white matter abnormalities in schizophrenia and bipolar disorder, finding distinct patterns between groups and age-related changes in schizophrenia.

A longitudinal model of human neuronal differentiation for functional investigation of schizophrenia polygenic risk

This study integrates GWAS risk data with longitudinal in vitro gene expression during neuronal differentiation to identify schizophrenia-related gene clusters.

The dark side of the mean: brain structural heterogeneity in schizophrenia and its polygenic risk.

This paper investigates brain structural heterogeneity in schizophrenia and finds that polygenic risk is associated with thinner fronto-temporal cortices and smaller hippocampal subfields, but not with increased variability.

A proof-of-principle study of the effect of combined haloperidol and levodopa administration on working memory-related brain activation in humans

This study investigates the effect of combined haloperidol and levodopa on working memory-related brain activation in humans, finding reduced activity in occipital/temporal areas and increased salience network connectivity.

Identifying the in vivo cellular correlates of antipsychotic drugs

The paper investigates the cellular mechanisms of antipsychotic drugs by identifying their in vivo targets and effects on neural circuits.

NMDA receptor blockade causes selective prefrontal disinhibition in a roving auditory oddball paradigm

This study investigates the effects of NMDAR blockade with ketamine on auditory processing using a roving oddball paradigm and dynamic causal modelling, finding selective prefrontal disinhibition.

The Valuation of Social Rewards in Schizophrenia

This study investigates whether individuals with schizophrenia undervalue social rewards, finding they treat genuine smiles as less rewarding than healthy participants, despite similar preferences for monetary rewards.