Schizophrenia research and treatment

Multi-scale analysis of schizophrenia risk loci: Integrating centenarian genomes and spatio-temporal expression profiles suggest the need for adjunctive therapeutic interventions for neuropsychiatric disorders.

The paper integrates centenarian genomes and spatio-temporal expression profiles to identify potential drug targets for schizophrenia, suggesting repurposed therapies for neuropsychiatric disorders.

Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia

This study uses genome-wide association data for educational attainment and schizophrenia to identify genetic heterogeneity and novel candidate genes for schizophrenia.

Modeling the schizophrenias: subunit-specific NMDAR antagonism dissociates frontal δ and hippocampal θ modulation of ~140 Hz oscillations

This study shows that NR2A-specific NMDAR antagonism increases delta-HFO coupling and decreases theta-HFO coupling, suggesting frontal hyperfunction and hippocampal hypofunction in schizophrenia-like states.

Developmental And Genetic Regulation Of The Human Cortex Transcriptome In Schizophrenia

The paper identifies 237 genes associated with schizophrenia using RNA sequencing and eQTL analysis, showing enrichment for developmentally regulated synaptic genes.

Age at first birth in women is genetically associated with increased risk of schizophrenia

The paper finds a genetic association between schizophrenia risk and age at first birth in women, with different genetic correlations in younger and older age groups.

Grey matter biomarker identification in Schizophrenia: detecting regional alterations and their underlying substrates

This paper develops a machine learning framework to identify sparse grey matter biomarkers in Schizophrenia and their biological substrates using structural MRI data.

Higher genetic risk for schizophrenia is associated with living in urban and populated areas

The paper finds a genetic association between schizophrenia risk and urban living, suggesting genetic factors influence migration to densely populated areas.

Isoform and protein region abnormalities of dysbindin and copper transporter proteins in postmortem schizophrenia substantia nigra.

The paper investigates dysbindin and copper transporter protein abnormalities in schizophrenia substantia nigra, finding altered expression patterns linked to medication status.

Building a schizophrenia genetic network: Transcription Factor 4 regulates genes involved in neuronal development and schizophrenia risk.

The paper identifies TCF4 binding sites and their association with schizophrenia risk genes, showing TCF4 regulates neural development genes and interacts with SZ-related loci.

GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation

This study creates a mouse model with a patient-derived NLGN2 R215H mutation, showing GABAergic deficits and schizophrenia-like behaviors.

The Impact of Reward on Attention in Schizophrenia

This study examines how reward influences selective attention in schizophrenia, finding that reaction times are slower in patients but reward and probability effects remain intact.

Dynamic expression of risk genes for schizophrenia and bipolar disorder across development

The paper examines the dynamic expression of risk genes for schizophrenia and bipolar disorder across developmental stages in brain regions, finding distinct expression patterns between the two disorders.

Placental gene expression mediates the interaction between obstetrical history and genetic risk for schizophrenia

The paper shows that placental gene expression mediates the interaction between obstetrical history and genetic risk for schizophrenia, with ELCs enhancing PRS effects.

Genetic Identification Of Brain Cell Types Underlying Schizophrenia

The paper maps schizophrenia-associated genomic loci to specific brain cell types using single-cell RNA-sequencing data, finding consistent enrichment in pyramidal cells, medium spiny neurons, and interneurons.

Polygenic risk score for schizophrenia is not strongly associated with the expression of specific genes or gene sets

The study examines whether polygenic risk scores for schizophrenia correlate with gene expression in brain tissue but finds no significant associations beyond chance.

Comprehensive pathway analyses of schizophrenia risk loci point to dysfunctional postsynaptic signaling

This study uses pathway analysis on schizophrenia GWAS data to identify enrichment in synaptic plasticity and neurotransmitter synapse gene sets, supporting a role for postsynaptic signaling in schizophrenia.

The neurobiology of BRD1 implicates sex-biased dysregulation of nuclear receptor signaling in mental disorders

This study investigates the role of BRD1 in sex-biased nuclear receptor signaling and its implications in mental disorders using mouse models and gene expression analysis.

Abnormal reward prediction error signalling in antipsychotic naive individuals with first episode psychosis or clinical risk for psychosis

This study examines reward prediction error signalling in individuals with first episode psychosis and those at risk for psychosis, finding abnormal midbrain and prefrontal cortex activation compared to healthy controls.

Impaired expected value computations coupled with overreliance on prediction error learning in schizophrenia

This study investigates decision-making impairments in schizophrenia by analyzing reward prediction error and expected value computations using computational modeling.

Genome-wide analysis of adolescent psychotic experiences shows genetic overlap with psychiatric disorders

This study finds genetic overlap between adolescent psychotic experiences and schizophrenia, bipolar disorder, and major depression using polygenic risk scores and genome-wide association analyses.

Weighted burden analysis of exome-sequenced case-control sample implicates synaptic genes in schizophrenia aetiology

The paper reanalyzes exome-sequenced schizophrenia cases and controls, finding significant enrichment of gene sets related to synaptic function, particularly involving FYN and NMDA receptor subunits.

Genetic risk for schizophrenia influences substance use in emerging adulthood: An event-level polygenic prediction model

This study uses polygenic scores to show that genetic risk for schizophrenia is linked to increased illicit drug use and age-related increases in substance use among young adults.

Matching drug transcriptional signatures to rare losses disrupting synaptic gene networks identifies known and novel candidate drugs for schizophrenia

The paper matches drug transcriptional signatures to synaptic gene network disruptions to identify known and novel candidate drugs for schizophrenia.

DLPFC Transcriptome Defines Two Molecular Subtypes of Schizophrenia

The paper identifies two molecular subtypes of schizophrenia based on differential gene expression in the dorsolateral prefrontal cortex using WGCNA.

High prevalence of the antibody against Syncytin-1 in schizophrenia

The paper examines antibody prevalence against Syncytin-1 in schizophrenia patients using ELISA, finding 50% positivity with high specificity.

Association between schizophrenia and both loss of function and missense mutations in paralog conserved sites of voltage-gated sodium channels

The paper identifies an excess of rare loss-of-function and missense mutations in voltage-gated sodium channels and synaptic genes associated with schizophrenia using large-scale sequencing and meta-analysis.

Impaired conscious access and abnormal attentional amplification in schizophrenia

This study investigates conscious perception and attentional processing in schizophrenia using event-related potentials, finding impaired top-down attentional amplification but preserved bottom-up processing.

Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions

The paper mutates zebrafish orthologues of schizophrenia-associated genes to identify phenotypic candidates and shared functions.

Association study of schizophrenia with variants in miR-137 binding sites

The paper tests if variants in miR-137 binding sites are associated with schizophrenia using exome sequencing data from 4225 cases and 5834 controls, finding a significant weighted burden test result.

The NDE1 genomic locus can affect treatment of psychiatric illness through gene expression changes related to MicroRNA-484

The paper investigates how genetic variation at the NDE1 locus affects gene expression and treatment response to psychiatric medications through interactions with microRNA-484 and CYP2C19.