Asthma and respiratory diseases

GSDMA drives the most replicated association with asthma in naïve CD4+ T cells

The paper identifies GSDMA as a gene in naive CD4+ T cells that modulates expression and methylation levels, driving the 17q12-21 asthma association.

Large-scale Genetic Analysis Identifies 66 Novel Loci for Asthma

This study identifies 66 novel asthma susceptibility loci through GWAS and finds gene-sex interactions and immune-related candidate genes, suggesting CD52 as a potential therapeutic target.

Genome-wide profiling of an enhancer-associated histone modification reveals the influence of asthma on the epigenome of the airway epithelium.

The paper identifies asthma-associated changes in H3K27ac enhancer marks in airway epithelial cells and validates their role in gene expression through CRISPR-based epigenome editing.

Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma

This study characterizes molecular changes in HDM-associated asthma using RNA sequencing, proteomics, and microbiome analysis to identify potential biomarkers and hypotheses.

Shared and distinct genetic risk factors for childhood onset and adult onset asthma: genome- and transcriptome-wide Studies

This study identifies shared and distinct genetic risk factors for childhood and adult onset asthma using GWAS and transcriptome-wide analysis, finding 61 loci with 23 childhood-specific, 1 adult-specific, and 37 shared.

Asthma and affective traits in adults: a genetically informative study

This study investigates genetic links between asthma and affective traits, finding shared genetic influences between asthma and depression, and neuroticism, but not anxiety.

Gene co-expression networks in whole blood implicate multiple interrelated molecular pathways in obese asthma

The paper uses gene co-expression networks in whole blood to identify molecular pathways associated with obese asthma, finding four modules linked to obesity and enriched for inflammatory pathways.

A Genome-wide Association and Admixture Mapping Study of Bronchodilator Drug Response in African Americans with Asthma

This study identifies genetic variants associated with bronchodilator drug response in African Americans with asthma, finding both population-specific and shared genetic factors across African American and Latino populations.

A Nasal Brush-based Classifier of Asthma Identified by Machine Learning Analysis of Nasal RNA Sequence Data

The paper develops a machine learning classifier for asthma using nasal RNA sequencing data, achieving high accuracy across multiple test sets.

Shared Genetic Architecture Of Asthma With Allergic Diseases: A Genome-wide Cross Trait Analysis Of 112,000 Individuals From UK Biobank

This study identifies shared genetic architectures between asthma and allergic diseases using genome-wide data from 112,000 individuals.

Whole Genome Sequencing of Pharmacogenetic Drug Response in Racially and Ethnically Diverse Children with Asthma

This study identifies pharmacogenetic variants associated with albuterol bronchodilator response in minority children with asthma using whole genome sequencing.

Non-parametric mixture models identify trajectories of childhood immune development relevant to asthma and allergy

The paper identifies three distinct immune development trajectories in childhood using unsupervised clustering, revealing a high-risk atopic cluster associated with allergic diseases.

Dynamics of the upper airway microbiome in the pathogenesis of asthma-associated persistent wheeze in preschool children

The paper tracks the upper airway microbiome changes in preschool children and links them to asthma-associated persistent wheeze, showing that bacterial shifts precede viral infections and symptoms in sensitized children.

Rapid evolution of primate type 2 immune response factors linked to asthma susceptibility

This study identifies rapid evolution of primate type 2 immune response factors, including IL13 and eosinophil granule proteins, linked to asthma susceptibility in humans.

Genome-wide association study of asthma in individuals of African ancestry reveals novel asthma susceptibility loci

This study identifies novel asthma susceptibility loci in individuals of African ancestry through genome-wide association analysis and admixture mapping.