Asthma and respiratory diseases

Apoptosis inhibition reprograms alveolar myofibroblasts toward ductal myofibroblasts

The paper shows that inhibiting apoptosis of alveolar myofibroblasts (AMFs) reprograms them into ductal myofibroblasts (DMFs) in a mouse model, suggesting fate plasticity in lung mesenchymal cells.

The Staphylococcus aureus serine protease-like protein B is a potent allergen in a murine asthma model

This study shows that S. aureus SplB induces asthma-like symptoms in mice, requiring proteolytic activity and adaptive immunity, suggesting a direct role of bacterial allergens in asthma.

The club cell circadian clock regulates temporal patterns in leukocyte trafficking in chronic allergic airways disease

This study shows the club cell circadian clock regulates time-of-day-dependent leukocyte trafficking and airway barrier integrity in chronic allergic airways disease.

Extracellular matrix phenotyping by imaging mass cytometry defines distinct cellular matrix environments associated with allergic airway inflammation.

The paper uses imaging mass cytometry to analyze ECM composition in mouse models of allergic airway inflammation, identifying distinct matrix environments associated with different cell types and tissue regions.

NO modulates human airway smooth muscle function by altering glucose-6-phosphate dehydrogenase effects on sGC function in asthma

This study shows that NO modulates airway smooth muscle function in asthma by altering G6PD effects on sGC function through redox regulation and heme-maturation.

Microbiome diversity, intra-mucosal bacteria and immune integration within normal and asthmatic airway mucosa

The paper examines microbiome diversity and immune interactions in airway mucosa of healthy and asthmatic individuals, finding associations between bacterial counts and immune network eigenvectors.

Nociceptor Neurons Control Pollution-Mediated Neutrophilic Asthma

This study shows that nociceptor neurons contribute to pollution-induced neutrophilic asthma by enhancing TRPA1 sensitivity and artemin release, which drives neutrophil recruitment.

Ovarian Hormones and Obesity Drive Th17-mediated Airway Inflammation through Estrogen Receptor Signaling

This study shows that estrogen receptor-alpha signaling in T cells increases Th17-mediated airway inflammation in obese female mice and that Th17 cells are more frequent in women with asthma compared to men.

Selective targeting of IL-1RAP-dependent eosinophilic inflammation in allergic fungal airway disease

This study identifies IL-1RAP as a target for reducing eosinophilia in allergic fungal airway disease using a mouse model of chronic A. fumigatus exposure.

Diverse microbial exposure exacerbates the development of allergic airway inflammation in adult mice

This study shows that increased microbial exposure in adult mice worsens allergic airway inflammation, while early exposure does not have the same effect.

Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma

This study compares T cell phenotypes and clonotypes from bronchoalveolar lavage and endobronchial brushings in healthy controls and allergic asthmatics, finding distinct transcriptional and TCR repertoire features.

GPR43 in Eosinophils Prevents the Emergence of Pathogenic Siglec-Fhi Neutrophils in Allergic Airway Inflammation

The paper shows that eosinophils modulate neutrophil differentiation into pathogenic Siglec-Fhi neutrophils via GPR43, exacerbating allergic airway inflammation.

Network Analysis Reveals Protein Modules Associated with Childhood Respiratory Diseases

The paper uses WGCNA to identify protein modules in 1-year-old children linked to respiratory diseases by age 6, showing associations with environmental and metabolomic factors.

The dichotomous impacts of semaphorin3E deficiency on exacerbating airway hyperresponsiveness, remodelling, and inflammation in type-2 low and type-2 high asthma models

This study investigates the role of Sema3E in type-2 low and type-2 high asthma models, showing it exacerbates airway hyperresponsiveness and inflammation in type-2 low but promotes mucus production and eosinophilia in type-2 high asthma.

Airway basal stem cells are necessary for the maintenance of functional intraepithelial airway macrophages.

This study shows that airway basal stem cells maintain intraepithelial airway macrophages via Notch signaling, enabling localized allergic inflammation in the trachea but not distal lung tissues.

Analysis of rare coding variants in 470,000 UK Biobank participants reveals genetic associations with childhood asthma predisposition

The paper analyzes rare coding variants in 470,000 UK Biobank participants and identifies genetic associations with childhood asthma predisposition, finding significant effects in FLG, IL33, and PRKCQ.

Rhinovirus as a Driver of Airway T-Cell Dynamics in Children with Severe Asthma

The paper uses machine learning to analyze T-cell dynamics in children with severe asthma, identifying rhinovirus-driven changes in T-cell signatures and differentiation pathways.

Withaferin A reduces pulmonary eosinophilia and IL-25 production in a mouse model of allergic airways disease

This study shows that Withaferin A reduces eosinophilic airway inflammation and IL-25 levels in a mouse model of allergic airways disease.

Integration of functional genomics and statistical fine-mapping systematically characterizes adult-onset and childhood-onset asthma genetic associations.

This study integrates functional genomics and statistical fine-mapping to identify causal variants, regulatory elements, and effector genes for adult-onset and childhood-onset asthma.

scRNA-seq identifies unique macrophage population in murine model of ozone induced asthma exacerbation

The paper uses scRNA-seq to identify unique macrophage and monocyte populations in a murine model of ozone-induced asthma exacerbation, linking them to inflammatory pathways and bronchial constriction.

Comprehensive sequencing of the lung neuroimmune landscape in response to asthmatic induction

This study maps neuroimmune transcriptomic changes in the lung during asthmatic induction, showing altered gene expression in specific cell clusters and spatial locations.

Single-cell analysis identifies distinct CD4+ T cells associated with the pathobiology of pediatric obesity-related asthma

The paper identifies distinct CD4+ T cell subtypes in obese asthma linked to CDC42 upregulation, Th1 inflammation, and steroid resistance.

Lung CD4+ resident memory T cells use airway secretory cells to stimulate and regulate neutrophilic allergic airways disease.

This study identifies lung CD4+ resident memory T cells and their interaction with airway secretory cells as key regulators of neutrophilic allergic airways disease in mice and humans.

IL-13 promotes sensory-sympathetic neurons crosstalk in asthma

The paper investigates how IL-13 reprograms airway nociceptor neurons during asthma, promoting sensory-sympathetic neuron crosstalk through NPY1R signaling.

Human pulmonary neuroendocrine cells respond to House dust mite extract with PAR-1 dependent release of CGRP

This study develops an in vitro human PNEC model to show HDM induces CGRP release via PAR-1 activation, suggesting a role in allergic asthma.

Requirement for Fucosyltransferase 2 in Allergic Airway Hyperreactivity and Mucus Obstruction

This study identifies fucosyltransferase 2 (Fut2) as essential for mucin fucosylation, which contributes to allergic airway hyperreactivity and mucus obstruction in mice.

Deciphering the Immune Subtypes and Signature Genes: A Novel Approach Towards Diagnosing and Prognosticating Severe Asthma through Interpretable Machine Learning.

This study identifies immune subtypes and signature genes in severe asthma using machine learning and transcriptomic data from a murine model and online database.

Asthma exacerbations and eosinophilia in the UK Biobank: a Genome-Wide Association Study

This study performs a GWAS on asthma exacerbations in the UK Biobank, identifying two novel genetic loci associated with exacerbation risk in individuals with asthma.

Single cell transcriptomics delineates the immune-cell landscape in equine lower airways and reveals upregulation of the FKBP5 gene in horses with asthma

The paper uses scRNA-seq to analyze immune cell populations in equine BAL fluid from horses with asthma and healthy controls, identifying FKBP5 as upregulated in asthma cases.

A dynamical model of TGF-β activation in asthmatic airways

This study develops a dynamical model of TGF-β activation in asthmatic airways, showing bistable states and how external stimuli can irreversibly shift the system from healthy to diseased states.