Gut microbiota and health

The gut microbiota metabolite isovalerate enhances the epithelial barrier function in cell monolayers derived from porcine ileum organoids

This study shows that isovalerate, a gut microbiota metabolite, enhances epithelial barrier function in porcine ileum organoid-derived cell monolayers by upregulating immunity and absorptive cell markers while reducing stem cell and mucus genes.

Investigation of Bile Salt Hydrolase Activity in Human Gut Bacteria Reveals Production of Conjugated Secondary Bile Acids

This study investigates BSH activity in human gut bacteria and finds that some strains can directly dehydrogenate conjugated bile acids to produce conjugated secondary bile acids, challenging the idea that deconjugation is a prerequisite for further modifications.

Phenotypic high-throughput screening identifies modulators of gut microbial choline metabolism

This study identifies chemical scaffolds that inhibit gut microbial choline metabolism and reduce TMAO levels in mice using phenotypic screening.

Association of human gut microbiota with Alzheimers disease pathogenesis: An exploratory clinical study

This study explores the association between gut microbiota and Alzheimer's disease by comparing fecal microbiota composition in AD patients and healthy adults, finding no statistically significant differences due to limited sample size.

Winter warming shapes gut microbiome composition and directional dysbiosis in a temperate lizard

This study examines how winter warming affects gut microbiome composition in lizards, finding that constant warming reduces microbial diversity and increases dysbiosis, while fluctuating temperatures preserve microbial stability.

Diet-Microbiome Analysis in a Healthy Cohort Reveals Potential Role of Intestinal Microbiota in Metabolism

The paper analyzes diet-microbiome interactions in a healthy cohort, identifying associations between dietary factors and microbial composition and pathways.

Sex-stratified Gut Microbiome Disruption is Associated with Altered Hepatic Gene Expression during Acute Azoxystrobin Exposure

This study shows that azoxystrobin exposure alters gut microbiota and liver gene expression in zebrafish, with sex-dependent effects, suggesting microbiome disruption contributes to host toxicity.

Insulin resistance modifies longitudinal multi-omics responses to habitual diet

The paper examines how diet affects gut microbiome and plasma metabolome across insulin resistance states, finding stronger diet-omics associations in insulin-sensitive individuals.

Multi-Omic Analyses of Dietary Fatty Acid-Microbe-Host Interactions Reveal Metaorganismal Lipid Metabolic Crosstalk Impacting Cardiometabolic Disease

This study investigates how dietary fatty acids interact with gut microbiota and host metabolism to influence lipid homeostasis and cardiometabolic disease in mice.

Diversity and stability of the gut microbiome of naked mole-rat (Heterocephalus glaber), the longest-lived rodent

This study characterizes the gut microbiome of naked mole-rats, revealing its stability across age and unique features associated with their low metabolic rate and longevity.

The impact of intermittent palatable food consumption on microbiota structure in male and female rats

This study investigates how intermittent palatable food consumption affects gut microbiota structure in male and female rats, revealing sex-based differences and microbial community shifts linked to feeding behavior.

Critical assessment of intratumor and low-biomass microbiome using long-read sequencing

The paper assesses low-biomass microbiome detection in tissues using long-read sequencing, finding that genuine microbiome signals are limited to tissues with natural microbial exposure.

A whole organism screening platform identifies gut microbiome microproteins that modulate host metabolism

The paper identifies gut microbiome microproteins that modulate host metabolism using a whole-organism screening platform in C. elegans.

Synergistic interactions between Bacteroides intestinalis and Arabinoxylan Mitigates Inflammatory and Metabolic Dysfunction

This study shows that pairing Bacteroides intestinalis with arabinoxylan reduces inflammation and metabolic issues in mice by altering metabolism and gene expression.

Cigarette smoke induces colon cancer by regulating the gut microbiota and related metabolites

This study shows smoking increases colorectal cancer risk by altering gut microbiota, metabolites, and suppressing tumor suppressor genes like CPT2.

The impact of dietary fibers on gut microbiome of young children: insights from ex vivo experiments and an observational cohort

The paper examines how specific dietary fibers affect the gut microbiome of young children using ex vivo experiments and observational cohort data, finding increased short-chain fatty acid production and beneficial metabolite generation.

Food-Allergic Children Harbour a Reduced Oral Bacterial Load, Giving Misleading 16S rRNA Amplicon Profiles

The paper reanalyzes oral microbiota data from food-allergic children using absolute abundance instead of relative abundance, revealing reduced bacterial load and altered functional predictions.

Characterization of the Gut Microbiota and Serum Metabolomics in Patients with Type 2 Diabetes Mellitus and Newly Diagnosed Acute Coronary Syndrome

This study identifies key gut microbiota and serum metabolite biomarkers that distinguish T2DM patients with ACS from those without, achieving high diagnostic accuracy using a multi-omics approach.

Diversity and prevalence of Anaerostipes in the human gut microbiota

This study characterizes genomic diversity within the Anaerostipes genus in the human gut, identifying three functional clusters and metabolic variability across species.

Human gut archaea collection from Estonian population

The paper presents a new collection of archaeal metagenome-assembled genomes from the Estonian population, expanding known archaeal diversity by 30%.

Host genotypes interact with microbial communities to modulate gene expression in the human intestine

The paper identifies gene-microbe interactions that modulate host gene expression in the human intestine and links them to IBD risk.

Revisiting the cancer microbiome using PRISM

PRISM improves microbial analysis in low-biomass sequencing data, identifies tumor-associated microbes in cancer datasets, and reveals potential clinical significance.

The impact of long-term levofloxacin on the bacterial gut microbiome of young South African children

This study examines how long-term levofloxacin affects gut microbiota in young children, finding that infants experience stunted microbial diversification that persists after treatment.

A Functional Metabolomics Framework to Track Microbiome Drug Metabolism

The paper develops a functional metabolomics framework using synthetic microbial communities and computational analysis to track drug metabolism by gut microbes, identifying metabolites and their correlations with microbial taxa.

The macroecological dynamics of sojourn trajectories in the human gut microbiome

This study characterizes the macroecological dynamics of sojourn trajectories in the human gut microbiome using theoretical models and empirical data.

Indigenous gut microbes modulate neural cell state and neurodegenerative disease susceptibility

This study shows that gut microbes influence the transcriptional states of brain cell types and affect neurodegenerative disease susceptibility, with E. coli specifically worsening Alzheimer's disease outcomes in mice.

A high fermentable fiber Western diet reduces indole levels

This study shows that adding fermentable fiber to a Western diet reduces indole levels and improves gut microbiota diversity and metabolic health in mice.

Revealing Interactions between Microbes, Metabolites, and Dietary Compounds using Genome-scale Analysis

The paper quantifies variation in gut microbial metabolism of dietary compounds and identifies compounds specific to few species, proposing a method for synbiotic design.

Riboflavin Deficiency-Induced Angular Stomatitis and Conjunctivitis in Associated with Gut Microbiota Dysbiosis

This study shows riboflavin deficiency in rats causes ariboflavinosis with angular stomatitis and conjunctivitis, linked to gut microbiota dysbiosis and altered glycan metabolism.

Age-specific modulation of gut-brain axis metabolites by galacto-oligosaccharides and nutrient blends in early childhood

This study examines how early-life nutritional interventions affect gut-brain axis metabolites in infants and young children, finding age-specific effects of galacto-oligosaccharides and nutrient blends.