Osteoarthritis Treatment and Mechanisms

This study uses iPSC-derived cartilage to show that the Arg719Cys COL2A1 mutation causes defective proteostasis, leading to abnormal matrix deposition and disease.

The paper identifies differentially expressed proteins and altered co-expression patterns in synovial fluid of end-stage OA patients compared to non-OA controls.

This study compares the effects of cartilage compression and joint instability on post-traumatic osteoarthritis progression after ACL injury in mice.

This study identifies GPNMB as an anti-inflammatory factor in cartilage, showing it reduces MMPs, ADAMTS4, and IL-6 expression and protects against post-traumatic osteoarthritis.

This study identifies SOX2 and SOX9 as regulators of LGALS3 promoter activity in SW1353 cells, showing dose-dependent repression and SOX9 binding.

This study identifies a unique transcriptomic signature in the temporomandibular joint (TMJ) compared to the knee, highlighting its vulnerability to osteoarthritis and validating an in vitro model.

This study identifies distinct mechano-response genes regulated by load-activated FGFR and beta1 integrins in chondrocytes, showing they control different subsets of genes.

The paper investigates regulatory interactions at the GDF5 locus, showing that epistasis between variants, rather than individual variants, influences disease risk and joint morphology.

This study investigates the role of LOXL2 in TMJ osteoarthritis, showing that its deletion worsens the condition while overexpression protects against chondrocyte apoptosis and inflammation.

This paper develops a computational model to simulate impact-induced cartilage damage, oxidative stress, and NAC treatment effects, showing NAC reduces proteoglycan loss by mitigating cell death and enzymatic depletion.

This study shows FGF8 promotes lipid droplet accumulation in chondrocytes through the FGFR1/p-p38 signaling pathway by upregulating perilipin1 expression.

This study shows CXCL16 drives synovial inflammation and joint pain through CXCR6, suggesting it as a target for treating post-traumatic osteoarthritis.

This study identifies Sirt5's role in regulating chondrocyte metabolism and osteoarthritis through lysine malonylation, showing its dysregulation contributes to OA in aging and obesity.

This study identifies GATA4 as a key factor in chondrocyte aging and osteoarthritis, showing its role in impaired regeneration and inflammation.

This study shows that small chemical molecules can repair osteoarthritis in rats by epigenetic reprogramming, improving cartilage structure and function.

This study develops a hypoxia-delivery scaffold for cartilage regeneration, showing improved collagen production and reduced unhealthy collagen types in human chondrocytes.

This study creates a cellular atlas of synovium in human and mouse knee osteoarthritis, identifying BHLHE40 as a key regulator of fibroblast activation and fibrosis.

This study identifies miR-126-3p as a biomarker for knee osteoarthritis, showing elevated levels in patients and reduced disease severity with mimic treatment.

This study stratifies equine osteoarthritis using metabolomic and proteomic profiles of synovial fluid and identifies markers for OA severity.

The paper identifies pyroptosis-related genes in osteoarthritis and constructs diagnostic models linked to immune infiltration.

This paper develops LTGF-β conjugated scaffolds to improve neocartilage development by mimicking native TGF-β activation, achieving better mechanical and biochemical properties compared to conventional TGF-β supplementation.

This paper presents a microfluidic co-culture system that models human joint inflammation in osteoarthritis by co-culturing multiple cell types and shows increased metabolic activity and viability in both healthy and diseased conditions.

This study shows EZH2 inhibition reduces cartilage damage, synovial inflammation, and pain in OA by modulating inflammatory, neuroimmune, and osteoimmune pathways.

The paper identifies OA risk genes by integrating eQTLs, chromatin accessibility, and 3D chromatin structure in human chondrocytes, revealing 13 putative risk genes, 10 of which are novel.

The paper investigates the role of subchondral bone marrow adipose tissue lipolysis in bone formation in hand osteoarthritis, finding that lipolysis correlates with bone formation markers and BMI.

The paper examines how 18-months of diet, exercise, or combined interventions affect the serum metabolome of knee OA patients, revealing sex-specific metabolic changes.

This study shows that adult zebrafish can regenerate functional synovial joints after complete removal, revealing a multipotent cell source and regenerative programs.

The paper identifies 38 high-confidence effector genes in osteoarthritis using molecular and functional genomics evidence from transcriptome analysis of primary tissues.

This study quantifies DNA methylation changes during human articular cartilage development and identifies epigenomic mediators of osteoarthritis risk in prenatal joint tissues.

The paper identifies response splicing QTLs in human chondrocytes and links them to osteoarthritis risk genes through alternative splicing analysis.