SARS-CoV-2 and COVID-19 Research

This study identifies molecular mechanisms of FCoV-23 pathogenicity, including receptor usage and biotype switching, and identifies a cross-reactive antibody for therapeutic development.

This study shows that CD4+ and CD8+ T cells are necessary to prevent SARS-CoV-2 persistence in the nasal compartment but not in the lungs.

This study measures the kinetics of SARS-CoV-2 virus-like particle internalization using live-cell microscopy, revealing key steps and their timing, and showing no effect of Omicron mutations or S protein cleavage site on internalization rates.

This study shows that advanced HIV infection leads to high intra-host SARS-CoV-2 spike diversity and adaptive evolution, potentially contributing to new variants of concern.

This study shows that certain SARS-CoV-2 antibodies enhance infection by cross-linking spike proteins, causing NTD-RBD domain decoupling without needing the Fc region.

This study develops bispecific antibodies that target conserved regions on the SARS-CoV-2 spike protein, showing improved neutralization breadth against multiple sarbecovirus strains.

The paper identifies potent nsp3-mac1 inhibitors but finds they do not translate to antiviral activity in cell culture models.

This study shows that a SARS-CoV-2 replicon DNA can express reporter genes in human cells without requiring T7 RNA polymerase or RNA replication.

This paper investigates the virological properties of the SARS-CoV-2 KP.3.1.1 variant, finding it has higher transmissibility and immune evasion compared to KP.3.

This study examines the phenotypic effects of mutations in SARS-CoV-2 RdRp subunits using biochemical assays, finding that some mutations alter enzyme stability, complex assembly, and activity, with implications for antiviral resistance.

This study identifies BTN3A2 as a primate-specific gene that inhibits SARS-CoV-2 infection by reducing ACE2 expression and blocking viral attachment.

The paper examines alveolar T cell responses in SARS-CoV-2 pneumonia patients, finding that early interferon signaling and targeting of structural proteins correlate with better clinical outcomes.

The paper shows that an infectious intermediate form of SARS-CoV-2 persists in vitro after protease inhibitor treatment, potentially explaining viral rebound in patients.

This study evaluates pemivibart's neutralizing activity against recent SARS-CoV-2 JN.1 sublineages and finds it has substantially reduced potency against KP.3.1.1.

This study identifies multiple distinct interactions of SARS-COV-2 nucleocapsid protein with host nuclear transport receptors, revealing mechanisms for nuclear import and other functions.

The paper shows that eosinophils protect against SARS-CoV-2 in vaccinated mice during breakthrough infections by reducing viral burden and limiting dissemination.

This study shows the Omicron variant's spike protein RBD binds more strongly to hACE2 and interacts with actin, suggesting potential changes in viral entry mechanisms.

This study identifies a phosphorylation-dependent conformational switch in SARS-CoV-2 nucleoprotein that inhibits RNA binding by altering domain interactions.

This paper identifies diverse functional antibodies targeting the S2 subunit of SARS-CoV-2 spike, including one with broad neutralization activity across multiple coronaviruses.

This study compares IgG antibody responses from SARS-CoV-2 infection, vaccination, and hybrid immunity, finding that hybrid immunity retains the imprint of the initial exposure and enhances antibody breadth and affinity.

This study examines how RBD mutations in SARS-CoV-2 affect adsorption to hydrophobic and hydrophilic surfaces, revealing structural deformations and distinct landing-footprints.

This study investigates the inhibition of coronaviral main proteases by PF-00835231, showing broad-spectrum activity and providing structural insights into its binding modes.

This paper presents an optimized protocol for generating spike trans-complemented SARS-CoV-2 replicons with single-cycle infectivity in BSL-2 settings.

The paper identifies SARS-CoV-2 genetic markers associated with host domestication using a k-mer-based pipeline, revealing mutations and host-specific genomic patterns.

This study maps immunodominant sites on MERS-CoV spike glycoprotein targeted by infection-elicited antibodies in humans, showing peak neutralizing activity against S1 and RBD epitopes.

This study investigates how SARS-CoV-2 nsp14 proofreading affects nucleoside antiviral activity using genetic and pharmacological methods, finding that nsp14 attenuation increases sensitivity to nucleoside analogues.

The paper uses Deep Mutational Scanning to analyze SARS-CoV-2 PLpro mutations, identifying functional residues and drug-escape variants.