Pain Mechanisms and Treatments

The paper investigates how the human insula represents prediction errors during pain learning, finding that unsigned PEs are modality-unspecific while signed PEs are modality-specific.

This study identifies RAR-mediated homeostatic plasticity as a mechanism driving spinal disinhibition and mechanical allodynia after peripheral nerve injury.

This study shows that microglia regulate histamine-dependent and non-dependent itch transmission through distinct pathways, with histamine-dependent requiring the CX3CL1-CX3CR1 pathway.

This study shows that repeated peripheral nerve injury promotes exaggerated pain and mood disorders, which are linked to spinal microglial activation, and that FLT3 inhibition can prevent these effects.

This paper conducts two meta-analyses of PET radioligand studies to identify regions of shared and unique opioid and dopamine neurotransmission during pain-related processes.

This study investigates how sensory information and expectations influence pain processing in the brain using EEG, finding that sensory information shapes evoked responses while expectations affect oscillatory activity before stimuli.

The paper evaluates AC1 and AC8 mRNA expression in the ACC of mice with neuropathic pain and finds increased AC8 expression but no change in AC1.

The paper shows macrophages transfer mitochondria to neurons to resolve inflammatory pain through CD200R and iSec1 interactions.

This study shows that midazolam reduces anxiety-like behavior in mice observing a cagemate with chronic pain, suggesting a role for the amygdala in emotional contagion.

This study shows that high-fat diet-induced obesity in mice increases heat pain hypersensitivity via lysophosphatidylcholine activation of ASIC3 channels in dorsal root ganglia neurons.

This study examines sex differences in responses to choice-based thermal nociceptive tests in adult rats, finding marked sex-specific behaviors in thermal gradient and temperature place preference tests.

The paper profiles RNA in human DRGs from neuropathic pain patients, identifying sex-specific gene expression differences and neuro-immune pathways associated with pain.

This study examines how TNF-α affects GABAergic and dopaminergic neurons in the ventral periaqueductal gray of female mice, showing differential changes in excitability and synaptic transmission.

The paper analyzes fMRI data to dissociate objective and subjective aspects of pain processing by examining dynamic network activity during continuous heat pain exposure.

This study identifies miR-544-3p as a regulator of arthritis pain by targeting FcγRI in DRG neurons, showing its potential as a therapeutic target.

This study compares nociceptive detection thresholds and evoked potentials between Go-/No-Go and 2IFC procedures, finding that thresholds are influenced by response criteria.

This study shows that anxiety increases pain in an osteoarthritis model and reduces opioid effectiveness by altering endogenous opioid function.

The paper identifies a sex-specific neuronal mechanism of spinal hyperexcitability in pain models, showing differences in BDNF signaling between male and female rodents and humans.

The paper investigates the interaction between autonomic reactivity and descending pain control, finding that periaqueductal grey connectivity mediates this relationship.

The paper investigates brainstem to spinal cord noradrenergic pathways and their differential effects on spinal neuronal activity through optogenetic activation.

This study identifies cortical morphometric similarity remodelling in chronic pain and links it to transcriptomic changes in glial and neuronal genes across multiple pain syndromes.

This study investigates Nav1.7's role in axonal propagation in nociceptors using sodium channel blockers in mice, finding it essential in about 2/3 of C-fibre neurons and a lower proportion of muscle-innervating neurons.

This study shows that LXR agonist GW3965 improves peripheral neuropathy in aged mice by altering macrophage cholesterol and nerve fiber structure.

This study shows that non-ionotropic NMDA receptor signaling in the spinal dorsal horn is sufficient to reverse pain hypersensitivity through reconsolidation.

This study shows that ovine dorsal root ganglion neurons from osteochondral defect models exhibit increased excitability and TRPV1 function, indicating peripheral sensitization.

This study shows that tonic pain in healthy humans alters functional connectivity within the Descending Pain Modulatory Network, with specific connections predicting pain intensity and being modulated by pain.

This study investigates if temporal pain contrast enhancement can be induced by repetitive stimulation with different interstimulus intervals and finds it occurs for 5 and 15 seconds but not 25 seconds.

The paper uses machine learning to analyze single-trial laser evoked potentials (LEPs) in rats, identifying distinct Aδ- and C-fibre mediated responses that predict pain behavior.

The paper uses microarray analysis to identify potential biomarkers for neuropathic pain after brachial plexus avulsion by comparing gene expression in pain and control groups.

This study evaluates the analgesic and neuroprotective effects of etifoxine in a mouse model of diabetic neuropathy, showing reduced mechanical hyperalgesia and anxiety.