Developmental Biology and Gene Regulation

The paper uses single-cell RNA sequencing to study mouse limb development, identifying progenitor states and their differentiation into skeletal elements in a spatiotemporal pattern.

The paper identifies a sustained transcription factor code that defines neuronal diversity in Drosophila and shows how modifying this code can convert cell fates in vivo.

The paper monitors the endogenous Fgf8a gradient in zebrafish gastrulation and confirms its role as a morphogen by showing its graded distribution and signaling effects.

The paper identifies a conserved transcriptional program across metazoan lineages that drives cell differentiation, independent of lineage-specific factors.

This study identifies Polycomb Group proteins in crustaceans and shows they regulate Hox genes differently than in insects, revealing distinct regulatory mechanisms in body plan evolution.

This study investigates the role of BMP signaling in regulating germline stem cell self-renewal during Drosophila testis niche formation and maturation, finding it critical for germ cell identity and necessary/sufficient for maintaining a self-renewing stem cell population.

The paper investigates Hox gene cross-regulatory interactions in Parhyale hawaiensis, revealing combinatorial Hox gene function rather than posterior prevalence in specifying appendage identity.

The paper maps the molecular timeline and regulatory networks driving neural crest emergence in Xenopus tropicalis using single-cell transcriptomics and machine learning.

The paper shows that premature translation of Zelda, a zygotic genome activator, does not lead to early gene expression, highlighting the need for coordinated developmental processes.

This study identifies Nr6a1 as a master regulator of trunk-specific axial development in mice, controlling elongation, segmentation, and lineage allocation through Hox gene regulation and gene regulatory networks.

This study investigates the role of ecdysone signaling in early embryogenesis of the short-germ insect Blattella germanica, showing its critical role in germ band formation and segmentation.

This study identifies the pharyngeal pouches and mesenchyme regions involved in thymus formation in chick embryos and reveals a genetic program and signaling pathways that regulate this process.

The paper shows that p53-deficient embryonic stem cells outcompete wild-type cells during differentiation, eliminating them via apoptosis through local interactions.

This study identifies miR-1's regulatory roles in embryonic structures from all three germ layers by suppressing key signaling components and gene regulators.

This study shows maternal thyroid hormone (MT3) expands neural cell diversity in zebrafish spinal cord development by modulating NOTCH signaling in a cell non-autonomous manner, linking it to human AHDS pathology.

The paper examines cell proliferation and death patterns during development and metamorphosis in Schizocardium californicum, finding distinct proliferative patterns and limited cell death in larvae.

The paper uses single-cell RNA sequencing to study germ cell fate specification in sea stars, finding distinct regulatory mechanisms for Nanos and Vasa.

This study identifies Cul-5 as a regulator of nuclear positioning in Drosophila embryos and shows how the nuclear-to-cytoplasmic ratio is sensed to control the mid-blastula transition.

This study uses single-cell transcriptomics to define cell lineage specification in the chicken embryo's anterior lateral plate mesoderm and forelimb field, identifying molecular pathways and transcription factors involved in somatic and splanchnic fate decisions.

This study shows that cdon and boc synergistically promote hedgehog signaling in zebrafish, affecting neural crest cell migration through slow-twitch muscle and extracellular matrix defects.

The paper identifies Rnf149-related as a regulator of pharyngeal muscle fate specification in the cardiopharyngeal lineage, acting independently of the FGF/MAPK pathway.

This study investigates how geometrical tessellation determines tiling patterns in compound eyes, showing that hexagonal patterns in wild-type Drosophila transform into tetragonal patterns in small eye mutants.

The paper reports a direct budding mechanism of alveolar development distinct from the classical model of subdivision of large air sacs.

The paper identifies different temporal roles for Tartan and Toll-2 LRR receptors in actomyosin enrichment and polarization at parasegmental boundaries in Drosophila embryos.

The paper identifies Gas1 as a key mediator of species-specific jaw size variation through NCM-mediated SHH signaling regulation.

The paper shows that early-stage altricial bird embryos express genes involved in thyroid hormone pathways, suggesting they can respond to maternal thyroid hormone signals.

The paper investigates how avian embryos resume development after diapause by identifying TGF-β and pluripotency-related pathways regulated by temperature.

The paper shows that cell cycle differences create cortical tension differences, leading to cleavage furrow positioning and asymmetric mRNA partitioning, which separates germ layer fates.

The paper quantifies BMP signaling gradients in zebrafish embryos and shows how noise and Sizzled maintain the gradient during DV patterning.