Urinary Bladder and Prostate Research

A multi-scale vascular atlas of blood vessels within the urinary bladder of male and female mice

This paper creates a 3D vascular atlas of the mouse urinary bladder, revealing stereotypical arterial and venous networks established by early postnatal development.

Human spinal cord activation during filling and emptying of the bladder

This study uses functional ultrasound imaging to observe spinal cord activity during bladder filling and emptying, identifying pressure-responsive regions correlated with bladder pressure.

Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia

The paper links an age-associated CD8+ T cell subset to symptomatic benign prostatic hyperplasia through immune aging mechanisms.

Senescent mast cells contribute to the progression of benign prostatic hyperplasia via SCF/c-KIT mediated endothelial-mesenchymal transition

This study identifies senescent mast cells as drivers of benign prostatic hyperplasia through SCF/c-KIT-mediated endothelial-mesenchymal transition.

Ex vivo high-resolution nano-computed tomography imaging reveals spatial architecture of the adult male mouse lower urogenital tract

This study uses nanoCT imaging to analyze the murine lower urogenital tract anatomy, revealing structural details relevant to understanding BPH and improving mouse model translational relevance.

Descending Enkephalinergic Neurons in Barrington's Nucleus Gate Sex-Biased Control of Micturition

The paper identifies a specific neuronal population in Barrington's nucleus critical for urinary control and shows its sex-specific role in micturition.

BMI and BPH correlate with urinary microbiome diversity and lower urinary tract symptoms in men

The paper examines the urinary microbiome in men and finds associations between BMI, BPH, and lower urinary tract symptoms with microbiome diversity.

Void spot assay visualization optimization for use of Void Whizzard in rats (Rattus norvegicus)

This study optimizes Void Spot Assay (VSA) visualization techniques for rats using bright field, ultraviolet, and ninhydrin spray, finding that ninhydrin spray provides the best results for urine detection.

Complex carbohydrates catabolism capacity of bladder microbiota inhabiting healthy and overactive female bladders

This study investigates urinary free oligosaccharides and microbial gene capacity for glycan digestion in women with and without overactive bladder syndrome.

In situ observation of water transport through the urothelium with optical coherence tomography

This study uses OCT to show the urothelium absorbs and expels water in response to NaCl, challenging its traditional view as impermeable and linking osmotic stress to urothelial damage.

Adiponectin Signaling Regulates Urinary Bladder Function by Blunting Smooth Muscle Purinergic Contractility

This study investigates the role of adiponectin signaling in urinary bladder function, finding that its absence leads to altered bladder smooth muscle contractility and purinergic pathway changes.

Local urothelial cell-driven detrusor contractions

This study shows that urothelial cell signaling via P2X, muscarinic, Ca2+, GPCR, and exocytotic pathways can induce local bladder contractions without central nervous system involvement.

Infiltrating lipid-rich macrophage subpopulations identified as a regulator of increasing prostate size in human benign prostatic hyperplasia

The paper identifies lipid-rich macrophage subpopulations in BPH that correlate with prostate size and urinary symptoms.

An Open-Source Neurodynamic Model of the Bladder

The paper presents an open-source neurodynamic model of the bladder that improves upon existing models by incorporating a circadian rhythm and neural interventions, showing high correlation with animal data.

Extracellular vesicles mediate OxLDL-induced stromal cell proliferation in Benign Prostatic Hyperplasia

This study investigates how dyslipidemic conditions affect prostatic stromal cell proliferation and extracellular vesicle release, showing that OxLDL promotes proliferation and EV production, which may contribute to BPH progression.

Excitatory and Inhibitory Effects of Saphenous Nerve Stimulation on Two Different Bladder Conditons: Underactivity and Overactivity

This study examines how saphenous nerve stimulation affects overactive and underactive bladder conditions in cats, finding frequency-dependent effects on bladder capacity.

PROSTATE CELL HETEROGENEITY AND CXCL17 UPREGULATION IN MOUSE STEROID HORMONE IMBALANCE

This study identifies CXCL17 upregulation and macrophage subsets in mouse prostate under steroid hormone imbalance, linking them to foam cell formation and inflammation.

Human HPSE2 gene transfer ameliorates bladder pathophysiology in a mutant mouse model of urofacial syndrome.

This paper demonstrates that AAV-mediated HPSE2 gene transfer improves bladder function in a mouse model of urofacial syndrome by restoring neurogenic relaxation.

Changes in TP53 gene, telomere length, mitochondrial DNA, and its amount in benign prostatic hyperplasia patients

The paper investigates changes in TP53 gene, telomere length, and mitochondrial DNA in BPH patients, finding prolonged telomeres and mtDNA amount changes, but no TP53 mutations linked to BPH.

Machine Learning-based Classification of transcriptome Signatures of non-ulcerative Bladder Pain Syndrome

This paper uses machine learning to identify a three-gene mRNA signature that distinguishes non-ulcerative bladder pain syndrome from controls and detrusor overactivity patients.

Single cell transcriptional profiling of benign prostatic hyperplasia reveals a progenitor-like luminal epithelial cell state within an inflammatory microenvironment

This study uses single-cell RNA-seq to identify a luminal progenitor cell state in BPH linked to inflammation and MIF interactions.

Acute ampakines increase voiding function and coordination in a rat model of SCI

This study shows that ampakines improve bladder voiding and coordination in a rat SCI model by enhancing AMPA receptor function.

Genetic tools that target mechanoreceptors produce reliable labeling of bladder afferents

The paper identifies genetic tools for labeling non-nociceptive bladder afferents, showing they label CGRP-negative fibers and overlap partially with NFH.

Open source timed pressure control hardware and software for delivery of air mediated distensions in animal models

The paper presents an open-source hardware and software system for delivering timed pressure distensions in animal models using an Arduino-based solenoid valve controller.

Human - murine concordance of molecular signatures in nerve-sparing murine partial bladder outlet obstruction (NeMO)

This study compares gene expression changes in a nerve-sparing mouse bladder obstruction model (NeMO) with human data, identifying shared cytokine pathways and therapeutic implications.

ILK play a key role in partial bladder outler obstruction (PBOO) by regulation TLR4/NF-κB(p65) pathway

This study investigates the role of ILK in PBOO by showing its regulation of the TLR4/NF-κB(p65) pathway in both in vivo and in vitro models.

Activation of MrgprA3 and MrgprC11 on bladder-innervating afferents induces peripheral and central hypersensitivity to bladder distension

This study identifies MrgprA3 and MrgprC11 as functional receptors on bladder afferents that induce hypersensitivity to distension when activated, offering a potential therapeutic target for bladder disorders.

Chronic effects of short-term aerobic and anaerobic physical training on the ventral prostate of adult rats

This study examines how short-term aerobic and anaerobic training affects prostate structure and function in rats, finding distinct changes in blood vessels, smooth muscle, and inflammatory markers.

Voluntary wheel running improves outcomes in an early life stress-induced model of urologic chronic pelvic pain syndrome in male mice

This study shows that voluntary wheel running reduces UCPPS symptoms in male mice with early life stress, improving mechanical sensitivity, bladder output, and mast cell degranulation.

Prolonged inhibitory effect of repeated period tibial nerve stimulation on the micturition reflex in the rat

This study shows that repeated tibial nerve stimulation in rats increases micturition threshold volume, with effects lasting at least 5 hours.