Hearing, Cochlea, Tinnitus, Genetics

Predictors for Estimating Subcortical EEG Responses to Continuous Speech

This study compares simple and complex peripheral auditory models for estimating subcortical EEG TRFs in continuous speech, finding simple models yield similar results faster.

Parvalbumin and somatostatin: biomarkers for two parallel tectothalamic pathways in the auditory midbrain

This study identifies parvalbumin and somatostatin as biomarkers for two distinct tectothalamic pathways in the auditory midbrain, revealing functional differences in their connectivity and electrophysiological properties.

Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial compartment of the developing cochlea

This study investigates the role of Jag1 in repressing Notch activation in lateral supporting cells and its impact on outer hair cell development in the cochlea using a mouse model of Alagille syndrome.

Mapping the developmental potential of mouse inner ear organoids at single-cell resolution

The paper uses single-cell sequencing to analyze the cellular heterogeneity of mouse inner ear organoids and compares it to in vivo data, identifying distinct hair cell subtypes and developmental trajectories.

Chromatin remodeling protein CHD4 regulates axon guidance of spiral ganglion neurons in developing cochlea

This study shows that CHD4 regulates axon guidance in spiral ganglion neurons by modulating chromatin at cis-regulatory elements to control axon guidance molecules.

Cisplatin drives mitochondrial dysregulation in sensory hair cells

This study shows cisplatin accumulates in hair cell mitochondria and causes dysregulation, linking mitochondrial dysfunction to cisplatin-induced hearing loss.

Estimation of cochlear frequency selectivity using a convolution model of forward-masked compound action potentials

This paper estimates cochlear frequency selectivity using a convolution model of forward-masked compound action potentials in chinchillas, showing close agreement with auditory nerve tuning curves.

A rare haplotype of the GJD3 gene segregating in familial Meniere Disease interferes with connexin assembly

The paper identifies a rare GJD3 haplotype associated with familial Meniere Disease, showing it disrupts connexin assembly and affects inner ear function.

EBF1 limits the numbers of cochlear hair and supporting cells and forms the scala tympani and spiral limbus during inner ear development

This study shows that EBF1 is crucial for inner ear development, regulating cochlear structure and cell numbers, and is necessary for normal hearing function.

Microvilli regulate the release modes of alpha-tectorin to organize the domain-specific matrix architecture of the tectorial membrane.

The paper identifies two distinct release modes of alpha-tectorin (TECTA) mediated by microvilli and proteolytic shedding, which determine domain-specific matrix organization in the tectorial membrane.

Intensity mismatch asymmetry in tinnitus: in which direction should participants pay attention?

The paper investigates how attention affects Mismatch Negativity (MMN) responses to intensity deviants in tinnitus patients and controls, finding differential effects based on attention type and deviant direction.

Distinct profiles of tinnitus and hyperacusis in intensity deviant responses and auditory evoked potentials

The paper assesses ERP responses to intensity deviant stimuli in groups with different combinations of tinnitus and hyperacusis, revealing distinct profiles and interactions between the conditions.

Effects of the overall paradigm context on intensity deviant responses in healthy subjects

The paper investigates how different frequency paradigms affect Mismatch Negativity responses in healthy controls using three experimental designs with varying frequency differences.

Hearing Ability of Prairie Voles (Microtus ochrogaster)

This study measures hearing ability in prairie voles, finding sex-specific differences in monaural hearing but not binaural hearing or morphology.

Extending Subcortical EEG Responses to Continuous Speech to the Sound-Field

This study measures subcortical responses to continuous speech in sound-field conditions and finds that 16 minutes of data is sufficient to reliably estimate TRFs with clear wave V peaks.

Transcriptomic Analysis Identifies Candidate Genes for Differential Expression during Xenopus laevis Inner Ear Development

The human pupil and face encode sound affect and provide objective signatures of tinnitus and auditory hypersensitivity disorders

The paper identifies objective signatures of tinnitus and auditory hypersensitivity disorders through pupil dilation and facial movement analysis in response to sound valence.

Anion efflux mediates transduction in hair cells of zebrafish lateral line

This study shows that zebrafish lateral line hair cells use anion efflux, not cation influx, for mechanotransduction due to low external cation concentrations.

Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line

This study shows that Kremen1 inhibits Wnt signaling and hair cell formation in zebrafish lateral line, and its absence leads to excessive regeneration through increased support cells when Wnt is overactivated.

Optogenetics reveals roles for supporting cells in force transmission to and from outer hair cells in the mouse cochlea

The paper uses optogenetics to study the role of supporting cells in force transmission to and from outer hair cells in the mouse cochlea, finding that hyperpolarizing these cells suppresses cochlear amplification and alters mechanical responses.

Subcortical Auditory Model including Efferent Dynamic Gain Control with Inputs from Cochlear Nucleus and Inferior Colliculus

The paper develops an auditory model with efferent gain control that simulates increased firing rates in inferior colliculus neurons in response to amplitude-modulated noise.

Profile analysis in listeners with sensorineural hearing loss: behavioral data and computational models

The paper measures profile analysis in listeners with sensorineural hearing loss and models the results using computational models of the auditory system, finding that hearing loss and higher frequencies correlate with poorer performance.

A fast and flexible approximation of power-law adaptation for auditory computational models

The paper introduces a fast approximation of power-law adaptation for auditory models, improving computational efficiency while maintaining accuracy.

Cochlear transcriptome analysis of an outbred mouse population (CFW)

The paper analyzes the cochlear transcriptome of an outbred mouse population to identify cell-type specific changes associated with age-related hearing loss.

Accurate phenotypic classification and exome sequencing allow identification of novel genes and variants associated with adult-onset hearing loss

Sensory progenitors influence patterning of the mammalian auditory sensory epithelium.

This study identifies Mybl2 as a Wnt-regulated gene that influences boundary formation and sensory epithelium size in the murine cochlea by regulating progenitor niche and sensory domain positioning.

Cochlear organoids reveal epigenetic and transcriptional programs of postnatal hair cell differentiation from supporting cells

The paper identifies transcriptional and epigenetic programs driving hair cell differentiation from supporting cells in cochlear organoids and predicts novel regulatory factors.

Targeted Deletion of All Known Thyroid Hormone Receptors Causes Maturation Retardation and Early-onset Degeneration of Cochlear Outer Sulcus

This study shows that thyroid hormone receptors are essential for cochlear outer sulcus development and endocochlear potential maintenance in mice.

From the outer ear to the nerve: A complete computer model of the peripheral auditory system

The paper presents a complete computer model of the peripheral auditory system integrating all components to study hearing mechanisms and deafness.

Individual similarities and differences in eye-movement-related eardrum oscillations (EMREOs)

The paper investigates eye-movement-related eardrum oscillations (EMREOs) in individuals with normal hearing, identifying consistent and variable features of these responses.