Hearing, Cochlea, Tinnitus, Genetics

Alterations of auditory sensory gating in mice with noise-induced tinnitus treated with nicotine and cannabis extract

This study investigates how noise-induced tinnitus affects auditory gating in mice and whether cannabis extract and nicotine can improve auditory pre-attentional processing.

Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells

This study shows reducing Cldn9 levels pharmacogenetically generates functional inner hair cells in mice, which are durable and resemble normal cells.

Wireless electrocochleography in awake chinchillas: a model to study multimodal modulations at the peripheral level

This study uses wireless electrocochleography in awake chinchillas to investigate corticofugal modulation during audiovisual crossmodal stimulation, finding no significant differences in auditory responses.

Cochlear tuning characteristics arise from temporal prediction of natural sounds

The paper shows that cochlear tuning properties resemble those of an artificial neural network optimized for temporal prediction of natural sounds.

Corticofugal oscillatory modulation of the cochlear receptor during auditory and visual attention in tinnitus

This study examines oscillatory activity in tinnitus patients during auditory and visual attention, finding altered corticofugal pathways and increased theta power in frontal EEG regions.

Revisiting the potency of Tbx2 expression in transforming outer hair cells into inner hair cells at multiple ages in vivo

This study investigates the effects of Tbx2 overexpression on OHC transdifferentiation into IHC-like cells across different ages, finding partial but incomplete reprogramming.

Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities

The paper identifies facial motion energy (FME) as a sensitive measure of hearing abilities in mice, showing its reliability and ability to decode speech in noise.

Crosstalk between glucose metabolism and morphogen signalling specifies tonotopic identity in developing hair cells.

The paper shows that glucose metabolism and morphogen signaling interact to establish tonotopic identity in developing hair cells by altering metabolic gradients and morphogen signaling.

Supporting-cell vs. hair-cell survival in the human cochlea: Implications for regenerative therapies

The paper assesses supporting-cell survival in human cochleas and finds it correlates with audiogram slope and ototoxic hearing loss.

Inhibitory G proteins play multiple roles to polarize sensory hair cell morphogenesis

This study identifies the distinct roles of GNAI proteins in mouse auditory hair cell polarization and morphogenesis, revealing compensatory mechanisms and novel defects upon their inactivation.

Calcium and Integrin-binding protein 2 (CIB2) controls force sensitivity of the mechanotransducer channels in cochlear outer hair cells

This study investigates the role of CIB2 in mechanotransducer channels of cochlear outer hair cells, finding that a mutation alters channel properties and force sensitivity.

TRPA1 activation in non-sensory supporting cells contributes to regulation of cochlear sensitivity after acoustic trauma

This study shows TRPA1 activation in cochlear supporting cells leads to prolonged Ca2+ responses and contractions that affect cochlear sensitivity after acoustic trauma.

A frame and a hotspot in cochlear mechanics

The paper identifies a 'hotspot' and 'frame' in the cochlea's organ of Corti complex, showing that the hotspot moves nonlinearly with sound and the frame is shielded from sub-BF activity.

Reducing tinnitus via inhibitory influence of the sensorimotor system on auditory cortical activity

This study investigates how sensorimotor system modulation affects tinnitus perception using magnetencephalography, finding increased alpha-band connectivity and reduced gamma power in the auditory cortex during relaxation.

Deciphering the genetic interactions between Pou4f3, Gfi1 and Rbm24 in maintaining cochlear hair cell survival

This study investigates the genetic interactions between Pou4f3, Gfi1, and Rbm24 in cochlear hair cell survival using mouse models and identifies regulatory elements and expression patterns.

Cortical Activity Associated With Acute Development of Phantom Auditory Percepts via Unilateral Deprivation

The paper measures cortical activity changes associated with acute tinnitus-like percepts induced by unilateral auditory deprivation using MEG.

Highly branched and complementary distributions oflayer 5 and layer 6 auditory corticofugal axons in mouse.

The paper examines branching patterns of layer 5 and 6 auditory corticofugal axons in mice, finding they have complementary distributions and extensive branching.

Web-based Psychoacoustics: Hearing Screening, Infrastructure, and Validation

This paper develops and validates a web-based platform for psychoacoustic experiments, showing agreement with lab-based results on multiple tasks.

High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

ZBTB20 is Essential for Cochlear Maturation and Hearing in Mice

This study identifies ZBTB20 as essential for cochlear maturation and hearing in mice by regulating terminal differentiation of non-sensory epithelial cells.

A Single-Cell Level Comparison of Human Inner Ear Organoids and the Human Cochlea and Vestibular Organs

This study compares single-cell transcriptomic profiles of human inner ear organoids with fetal and adult inner ear tissues to assess their ability to model inner ear disorders.

Rescue of Auditory Function by a Single Administration of AAV-TMPRSS3 Gene Therapy in Aged Mice of Human Recessive Deafness DFNB8

This study shows that a single AAV2-hTMPRSS3 injection rescues auditory function in aged mice with DFNB8 deafness, restoring it to wildtype levels.

Frequency-dependent Distribution of Different Subtypes of Spiral Ganglion Neurons in the Cochlea and the Changes During Aging

The paper examines the distribution of spiral ganglion neuron subtypes along the cochlea and their changes with aging in mice, finding a frequency-dependent pattern and age-related loss of Ic SGNs in the base.

Repair of Noise-Induced Damage to Stereocilia F-actin Cores is Facilitated by XIRP2

The paper shows that XIRP2 facilitates repair of noise-induced damage to stereocilia F-actin cores in mouse auditory hair cells by enriching monomeric gamma-actin at damaged sites.

The vestibular calyceal junction is dismantled following subchronic streptomycin in rats and sensory epithelium stress in humans

The paper shows that vestibular calyceal junction dismantlement occurs in rats with streptomycin-induced ototoxicity and in human sensory epithelia under stress, preceding hair cell loss.

Non-invasive optical synthetization of hearing sensation in non-genetically modified animal

This study shows that infrared laser stimulation of the cochlea can elicit and enhance auditory perception in gerbils, comparable to sound stimuli, and can be used to improve auditory prostheses.

The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear

The paper identifies STK32A as a kinase regulated by EMX2 that determines hair cell planar polarity orientation in the mouse inner ear, with STK32A promoting bundle alignment opposite to EMX2's effect.

Developmental exposure to polychlorinated biphenyls prevents recovery from noise-induced hearing loss and disrupts the functional organization of the inferior colliculus

This study shows that developmental PCB exposure impairs recovery from noise-induced hearing loss and disrupts auditory midbrain organization in mice.

Simple and efficient auditory-nerve spike generation

The paper presents a method to generate auditory-nerve spike trains by applying a time- and interval-dependent thinning process to a Poisson process, enabling efficient simulation of neural auditory perception.

Structure and dynamics that specialize neurons for high-frequency coincidence detection in the barn owl nucleus laminaris

This paper investigates how barn owl nucleus laminaris neurons achieve high-frequency interaural time difference sensitivity through specific structural and dynamical mechanisms.