Cellular Mechanics and Interactions

This study identifies Dachsous as essential for epithelial wound closure by modulating cell shape changes and cytoskeleton dynamics in Drosophila embryos.

This study shows that T cells respond to mechanical heterogeneity by not averaging signals, leading to lower activation than on stiff surfaces, but long-term exposure enhances memory and effector T cell proliferation.

This study shows that intercellular adhesion can drive collective cell migration through membrane tension and phospholipase D2 signaling, independent of cytoskeletal coupling.

The paper introduces a simplified agent-based framework for modeling cell-ECM interactions using PhysiCell, demonstrating its utility in various biological processes.

The paper identifies that Rac-mediated WAVE and Arp2/3 basolateral recruitment drives apical constriction during C. elegans gastrulation.

The paper reports the crystal structure of Anopheles gambiae ADF, showing high affinity for monomeric actin and structural features relevant to its function.

This study develops a method using optical tweezers to accurately measure cellular mechanics, showing sensitivity to cytoskeleton perturbations.

The paper determines the structure of the F-tractin-F-actin complex using cryo-EM, revealing how F-tractin binds actin and induces bundling.

This study reveals how zyxin assemblies coordinate actin nucleation and crosslinking to repair stress fibers in response to mechanical forces.

The paper investigates how cytoskeletal filaments influence cytoplasmic viscoelasticity along the apicobasal axis, showing that actin and vimentin dynamics regulate mechanical properties in different regions.

This study shows that polyploidy in MDA-MB-231 breast cancer cells increases extravasation through enhanced cell-matrix adhesion.

This study uses microgroove substrates to show that adherent cells exhibit dynamic 3D nuclear deformations driven by adhesion, with implications for diagnosing nuclear mechanical disorders.

This study shows that the stiffness of artificial axons affects myelin formation by oligodendrocytes and their response to drugs.

This paper develops a network model of the membrane skeleton integrating myosin and membrane mechanics to show that membrane bending and spectrin/myosin turnover are critical for maintaining structural stability under mechanical stress.

The paper quantifies out-of-plane residual stresses in Volvox embryos during folding and shows they guide cell sheet morphogenesis alongside cell wedging.

This study investigates how fascin's structural plasticity enables flexible actin bundle formation through cryo-EM, tomography, and modeling.

This study shows matrix rigidity enhances M2 macrophage activation by altering nuclear mechanics and chromatin accessibility through cooperation with biochemical signals like IL4/13.

This study shows that motor-driven cargo transport can sort actin filaments into polarity domains separated by cargo clusters, with effects influenced by cargo number, motor density, and filament length.

The paper introduces the STIPS algorithm to track merging and splitting events in dynamic biopolymer networks, revealing distinct rhythmic dynamics in actin microridges.

This study investigates how actin networks coexist under resource competition by using a reconstituted system, showing that protein turnover enables coexistence but intense competition favors stronger networks.

The paper studies oscillations in epithelial cell trains, showing that spontaneous oscillations depend on cell train size and exhibit resonance when subjected to external deformations.

The paper shows that α-catenin phosphorylation during mitosis prevents apical rounding and epithelial barrier leak by strengthening cell-cell interactions.

This paper investigates how stem cells adapt to mechanical cues by remodeling their cytoskeleton, showing that microtubule stabilization and substrate compliance significantly influence cell mechanics and morphology.

This paper investigates how microtubule stabilization and mechanical compression affect cytoskeletal remodeling in stem cells, showing changes in cell mechanics and structure.

The paper investigates mechanical instability in bladder epithelium at cancer onset, showing stiffness changes and morphological features similar to early tumors.

The paper models cell alignment with collagen fibrils using a hybrid model showing mechanosensitive focal adhesions drive ECM-dependent cell elongation.

The paper shows that increased cell contractility in pre-tumoral tissues drives tumour aggressiveness through dysplasia and junction weakening.

This study shows that substrate curvature affects macrophage cytoskeletal dynamics and immunophenotype, offering a localized strategy to modulate macrophage behavior.

The paper uses cSTAR to analyze endothelial cell transcriptomic states under different flow conditions, identifies CDK2 as a key regulator of artery remodeling.