Memory and Neural Mechanisms

Prior experience establishes a proactive cortical filter that blocks redundant associations

The paper shows that prior auditory learning inhibits somatosensory responses in mice through ACC-S1 projections, promoting blocking of redundant associations.

Dissociation between impaired explicit spatial remapping and preserved implicit neural dynamics in Alzheimers disease

This study identifies a dissociation between impaired explicit spatial remapping and preserved implicit neural dynamics in Alzheimer's disease using a rat model.

Coordinated acetylcholine release and adaptation of neuronal representations in the retrosplenial cortex during contextual uncertainty

The paper shows acetylcholine release in the retrosplenial cortex correlates with changes in expected uncertainty and influences neuronal representation shifts and learning speed in mice.

Stress drives the hippocampus to prioritize statistical prediction over episodic encoding

This study shows acute stress shifts hippocampal processing from episodic encoding to statistical learning, enhancing predictive feature representation and suppressing pattern separation.

Hippocampal CA3 forms a two-layer network of molecularly distinct cell types in mice and humans

The paper identifies two molecularly distinct subtypes of CA3 pyramidal neurons in mice and humans, revealing their unique anatomical and functional roles in hippocampal circuits.

Balancing Stability and Flow in Hippocampal Networks via Inductive Bias and Learned Symmetry Breaking

This paper shows how recurrent neural networks balance stability and flow in hippocampal networks through symmetry breaking and structured connectivity.

Medial prefrontal cortex encodes but is not required to generate goal-directed actions under threat

The paper investigates how medial prefrontal cortex (mPFC) GABAergic neurons encode and contribute to goal-directed actions under threat, finding that they encode cues, actions, and outcomes but are not required for action execution.

Architecture shapes event boundaries: Theta dynamics of event segmentation during spatial transitions

The paper examines neural dynamics during spatial transitions, finding increased theta-band power after passing through doorways, suggesting architectural boundaries influence event segmentation.

The emergence of a novel CA1 spatial map requires direct entorhinal input

The paper shows that direct entorhinal input is crucial for CA1 remapping in novel environments, enabling spatial map reorganization.

Hippocampal engrams configure prefrontal context representations to guide flexible decisions

This study shows that hippocampal engrams can configure prefrontal cortex representations to guide flexible decision-making in mice during context-dependent tasks.

Multiple event segmentation mechanisms in the human brain

This study identifies two distinct neural mechanisms for event segmentation in the human brain using fMRI and computational models, showing unique pattern shifts for error-driven and uncertainty-driven boundaries.

Prefrontal representations can specialize rather thangeneralize with experience

The paper shows that prefrontal cortex representations become specialized for specific task demands rather than generalizing with experience.

A Generalized Spatial Progress Code for Navigation in the Medial Prefrontal Cortex

The paper identifies a generalized spatial progress code in the medial prefrontal cortex that supports goal-directed navigation across different routes.

The medial entorhinal spatial map is built on excitatory-inhibitory network motifs defined by their functional cell type and theta modulation

The paper investigates how functional cell types and theta modulation shape connectivity in the medial entorhinal cortex to form spatial maps.

PACAPergic BAC engages basolateral amygdalar and anterodorsal thalamic networks during looming-threat learning and memory in a labyrinth

This study identifies the BAC as a PACAPergic hub linking emotional and spatial networks in looming-threat learning and memory using a novel behavioral paradigm and chemogenetic approaches.

Distinct hippocampal codes emerge during brain-machine interface navigation

This study shows that hippocampal place codes reconfigure during BMI-controlled navigation to form representations independent of locomotion and external cues.

Dual thalamic drive defines the intra-amygdala wiring complexity

The paper reveals a dual thalamic drive in intra-amygdala wiring in mice and humans, challenging the traditional serial flow model.

A Dual-Ensemble Model of Infralimbic Cortex Function in Behavioural Flexibility

This study proposes a dual-ensemble model of infralimbic cortex function in behavioural flexibility, showing that IL activity dynamically encodes predictive accuracy through action-outcome prediction and prediction correction.

Importance of Apparatus Scaling in Novel Object Recognition for Juvenile and Adult Rats.

This study shows that arena size affects novel object recognition performance in juvenile and adult rats, with weight-based scaling improving consistency in juveniles and sex differences in adults.

Y-maze performance predicts refined motor learning in mice

This study finds that Y-maze performance predicts pellet reaching task success in mice, indicating a link between exploratory behavior and motor learning.

Recurrent Connectivity Shapes Spatial Coding in Hippocampal CA3 Subregions

The paper shows that recurrent connectivity in hippocampal CA3 subregions shapes spatial coding strategies, with proximal neurons showing stable representations and distal neurons showing dynamic, context-specific activity.

Voltage Imaging of CA1 Pyramidal Cells and SST+ Interneurons Reveals Stability and Plasticity Mechanisms of Spatial Firing

The paper uses voltage imaging to study spatial firing patterns in CA1 pyramidal and SST+ interneurons, revealing stability and plasticity mechanisms during navigation and environment transitions.

Goal-directed hippocampal theta sweeps during memory-guided navigation

The paper identifies two types of hippocampal theta sequences in rats during memory-guided navigation and describes a circuit mechanism for goal-directed sweeps.

Medial entorhinal-hippocampal desynchronization parallels the emergence of memory impairment in a mouse model of Alzheimer's disease pathology

The paper examines neural activity in the medial entorhinal cortex and hippocampus of 3xTg mice, finding that reduced theta power and coherence, along with disrupted phase locking, coincide with the onset of spatial memory impairment in a model of Alzheimer's disease.

Time cells lead neural reinstatement of episodic memory

The paper identifies time cells and their role in temporal context recovery during episodic memory retrieval using human neurosurgical recordings.

Prevalence and modulation of rat off-track head-scanning on linear tracks: possible implications for representational and dynamical properties of hippocampal place cells

The paper investigates rat head scanning on linear tracks and its potential role in hippocampal place cell remapping and map formation.

The prefrontal cortex outputs to the amygdala facilitate threat-discrimination learning

This study shows that specific prefrontal cortex neurons projecting to the amygdala are essential for threat discrimination learning in mice.

Functional neural signatures of navigation impairment in early Alzheimer's Disease

This study identifies functional neural signatures of navigation impairment in early Alzheimer's Disease by linking biomarkers to specific brain activity patterns during navigation tasks.

Appetitive Pavlovian goal-tracking memory reconsolidation is reduced by both adrenergic and NMDA receptor antagonism

This study shows that both propranolol and MK-801 disrupt appetitive goal-tracking memory reconsolidation in rats, with propranolol's effects being consistent across sexes and reminder types.

Melanin-concentrating hormone signaling regulates prefrontal updating of learned avoidance

This study shows that blocking MCHR1 receptors in the prefrontal cortex helps mice stop responding to outdated warning signals while maintaining their ability to learn from danger.