Microtubule and mitosis dynamics

This paper studies how kinesin-1 motors transport liposome cargo through 2D and 3D microtubule intersections, finding that spatial relationships bias directional outcomes, with a higher straight-through rate at 3D intersections.

This study uses multiscale techniques to reveal the molecular structure of autoinhibited KIF5A, showing how its C-terminal tail contributes to autoinhibition and how mutations affect this state.

The paper identifies fisetin, a plant flavonol, as a potential therapeutic for KIF1A(R11Q)-associated neurological disorder by restoring ATPase activity and movement of the mutant protein.

This paper develops a microfluidic platform to engineer microtubule circuits by integrating microfabrication with microtubule branching reactions, enabling controlled MT architecture for on-chip applications.

This study shows dynein orients spindle migration in C. elegans epidermal stem cells, ensuring proper asymmetric division and tissue organization.

This paper shows that dysregulation of CycB:CDK disrupts cell cycle switches, leading to genome doubling, a common event in tumorigenesis.

This study identifies KIN-A and KIN-B as essential components of the chromosomal passenger complex in Trypanosoma brucei, showing they mediate CPC localization to kinetochores and the central spindle through distinct domains.

This study examines the development of tubulin-containing structures in Toxoplasma gondii using advanced imaging techniques, revealing distinct developmental patterns and symmetry changes.

The paper uses mass photometry to show heterogeneous distributions of kinesin-streptavidin complexes, attributing this to mixing ratios and biotinylation efficiency.

The paper identifies TRIM3 as a novel microtubule-binding protein using differential extraction proteomics and shows its role in acetylated tubulin accumulation.

The paper reports cryo-EM structures of PP2A:B55 bound to phosphorylated ARPP19 and FAM122A, revealing distinct binding mechanisms and providing insights for therapeutic development.

The paper describes the structure of the budding yeast outer kinetochore complexes and how phosphorylation regulates their stability during mitotic error correction.

This study shows that CENP-C must be expressed during meiotic prophase to ensure proper chromosome segregation, unlike CID which remains stable without prophase expression.

The paper uses TIRFM to study dynein-dynactin motility in human cells, finding fast processive movement with specific velocity and run length characteristics.

This study examines how alpha-tubulin acetylation affects doublet microtubule structure in Tetrahymena cilia using cryo-EM, MD, and mass spectrometry, finding small-scale structural changes and a link to phosphorylation.

The paper uses enucleated C. elegans embryos to study dynein-dependent centrosome spacing mechanisms and identifies a dynein-independent movement in later cell cycles.

This paper shows UNC-45A increases microtubule curvature and counteracts Taxol's straightening effects, suggesting a role in drug resistance.

The paper identifies a conserved arginine residue in the Dam1 complex subunit Dad2 that is essential for viability in yeast but less so in fungi with regional centromeres, suggesting functional plasticity in chromosome-microtubule coupling.

The paper reviews a model to quantify kinesin molecules engaged in axonal cargo transport and suggests their number could serve as biomarkers for neurodegenerative diseases.

The paper shows that Mis18 directly binds to SPB components to recruit Mis18C, promoting CENP-A chromatin assembly independently of centromeres.

The paper shows that yeast cells with impaired early anaphase Cdc14 release can complete meiosis without ribosomal DNA disjunction in meiosis I, suggesting this process is not essential for meiosis.

This study identifies Dunk as a regulator of myosin II during Drosophila cellularization by interacting with anillin to control its localization and function.

The paper shows that HDAC1 regulates α-tubulin acetylation in response to nutritional stress, affecting microtubule dynamics and mRNP transport in Drosophila germline cells.

The paper presents the high-resolution structure of a microtubule-like tube formed by FtsZ-monobody complexes, revealing structural similarities to microtubules and the role of FtsZ protofilament plasticity.

This study investigates the role of HpCTCF in sea urchin early development, showing it is essential for mitotic progression but not for later larval development.

The paper maps centriolar and PCM core protein localization in C. elegans post-embryonic lineage, showing cell fate determines centriole retention.

The paper shows that controlled PP1 activity oscillations are essential for proper meiotic progression in mouse oocytes, with disruptions causing severe meiotic defects.

This study identifies Kinesin-1's role in centrosome clustering and nuclear migration in Drosophila oocytes by showing its impact on centrosome activity and positioning.

This study shows that a sas-6(L69T) mutation in C. elegans disrupts centrosome duplication, ciliogenesis, and dendrite morphogenesis, contributing to microcephaly mechanisms.

This study identifies NSD3 as a regulator of cohesin loading during mitotic exit, showing its interaction with kollerin and its role in sister chromatid cohesion.