Microtubule and mitosis dynamics

This study identifies Bni5's role in tethering myosin-II to septins in budding yeast, enhancing retrograde actin flow and cytokinesis robustness.

The paper identifies a monomeric histone-fold domain in insect CENP-T proteins, showing structural rearrangements that replace the need for a CENP-W partner.

This study shows Pdk1 kinase localizes to eisosomes and regulates cytokinesis via Mid1 and Sid2, expanding its role beyond growth control.

This study shows POLO kinase phosphorylates PP187B to inhibit its interaction with MPS1, maintaining SAC activity and preventing aneuploidy during mitosis.

The paper shows Aurora A and CENP-E interact via a feedback loop to control chromosome congression by modulating kinetochore-microtubule attachments and spatial cues.

This study shows CENP-E initiates chromosome congression by stabilizing end-on attachments and counteracting Aurora B phosphorylation, promoting biorientation-dependent movement.

This study shows how actin and microtubule interactions coordinate during Drosophila oogenesis, revealing their mutual regulation in cytoskeletal organization.

This study investigates how DNA segregation and cell division are coordinated in archaea, identifying regulatory checkpoints and proteins involved in ensuring accurate genome distribution.

The paper shows that different fluorescent tags alter septin localization and function in fission yeast, highlighting the need for rigorous testing of tagged proteins.

This study directly observes the sequential and interdependent assembly of kinetochores on individual centromeres in budding yeast, revealing regulatory dependencies and a rate-limiting step in the process.

The paper shows Trim69 remodels microtubules to inhibit HIV virion core migration by stalling dynein/dynactin complexes.

The paper identifies PP6 phosphatase and Elongator as regulators of kinesin 5-dependent spindle assembly by controlling microtubule regulator levels in fission yeast.

The paper identifies spindle-associated proteins in Drosophila oocytes and reveals a phosphatase-driven mechanism for their spatial regulation.

The paper identifies a novel anaphase A mechanism in C. elegans embryos driven by KLP-7MCAK and opposed by KLP-18, showing its role in asymmetric chromosome segregation and mechanical coordination with anaphase B.

This study examines kinetochore structure and function in Arabidopsis thaliana, identifying conserved and plant-specific features of the kinetochore and SAC.

This study identifies the mechanism by which Kip2 promotes microtubule growth through a bipartite polymerase module that delivers tubulin to microtubule plus-ends.

The paper shows maternal CENP-C restores centromere symmetry in zygotes by asymmetrically recruiting to paternal centromeres, ensuring proper chromosome segregation.

This study shows that overexpressed MAD1 forms phase-separated condensates that drive mitotic slippage by sequestering MAD2 and weakening the mitotic checkpoint.

This study shows Srs2 in yeast and PARI in human cells delay abscission to prevent chromatin bridge damage during cytokinesis.

This study shows that Kif9 regulates centriolar satellite positioning and mitotic progression by affecting centrosome maturation and proteostasis.

This study identifies spindle-localized F-actin as critical for organizing polar MTOCs and ensuring accurate meiotic spindle formation and chromosome segregation in mammalian oocytes.

This study shows that CENP-A incorporation in human cells during G1 is independent of transcription and cohesin, contrasting findings in Drosophila.

This study identifies MLL and WDR5's role in recruiting KIF2C to the midbody to ensure proper microtubule depolymerization and furrow compaction during cytokinesis.

This study shows that PLK-1 phosphorylation of SPD-5 modulates the viscoelastic properties of the PCM scaffold in C. elegans embryos, affecting its size, integrity, and function.

This study shows STMN2 stabilizes by binding to tubulin, reducing its membrane localization and degradation, and proposes its neuroprotective role depends on its membrane-bound form.

The paper shows that Aurora A regulates NuMA's phase state at spindle poles, affecting nuclear organization during mitotic exit.

This paper uses computational modeling to show that cell geometry and orientation-dependent microtubule dynamics influence cortical microtubule array organization, with curvature and anchoring processes playing key roles.

This study identifies PCMD-1's role in stabilizing the PCM scaffold and facilitating centriole separation during mitosis in C. elegans.

The paper investigates the role of β-tubulin CTT in Kip3 depolymerase activity using yeast, finding it necessary for Kip3-tubulin complex formation but not microtubule binding or motility.

The paper shows UNC-83 isoforms differentially regulate kinesin-1 and dynein to control nuclear migration directionality during development.