Cancer-related molecular mechanisms research

This study identifies 5,053 novel virus long non-coding RNAs (vlncRNAs) across 25 viral species and finds that many structurally mimic host lncRNAs, potentially acting as miRNA sponges.

This study performs a systematic review and meta-analysis of lncRNAs as prognostic biomarkers in gastric cancer through ceRNA network studies, identifying two lncRNAs with significant prognostic value.

The paper identifies novel prognostic mRNA-miRNA-lncRNA interactions in stomach adenocarcinoma through bioinformatics analysis.

The paper validates HepaRG cells as a model for studying TRIBAL, showing functional overlap with hepatocytes and highlighting TRIBAL's role in metabolic regulation.

The paper shows JMJD6 and YBX1 physically interact and regulate HOTAIR promoter activity through a positive feedback loop, contributing to tumor progression.

The paper identifies cancer driver lncRNAs by analyzing their association with cancer driver genes and topologically associated domains, revealing 256 oncogenic, 177 tumor suppressive, and 75 dual-function lncRNAs.

LncCE identifies and characterizes cellular-elevated lncRNAs across normal and cancer tissues using single-cell RNA sequencing data, providing expression patterns and clinical associations.

This study identifies functionally important structural modules of SChLAP1 that drive cancer cell proliferation and invasion in prostate cancer.

The paper identifies lncRNAs that coordinately regulate both transcription and post-transcriptional processing of their targets, showing tight coupling between lncRNA and target abundance, with implications for cancer gene regulation.

LncPTPred predicts lncRNA-protein interactions using CLIP-Seq data, outperforming existing tools and providing interaction segments for validation experiments.

The paper identifies lncRNAs involved in melanoma growth and metastasis using CRISPR-inhibition screens and validates their functional roles.

This study introduces a dual CRISPRi system to target lncRNAs in melanoma cells, enabling synthetic lethal screening to identify cancer-specific lncRNA interactions for therapeutic strategies.

The paper identifies lncRNAs crucial for cSCC tumor growth using CRISPRi screens and single-cell sequencing.

POCALI identifies cancer lncRNAs by integrating 44 multi-omics features, showing improved sensitivity and strong associations with cancer phenotypes.

The paper uses a CRISPRi screen to identify lncRNAs critical for human monocyte viability, finding two lncRNAs that regulate proliferation and cell cycle genes.

The paper investigates how transcriptional stochasticity influences the regulation of Xist and Tsix at the XCI locus through different mechanisms based on nascent transcription levels.

The paper identifies a 36-base hairpin in lncRNA DRAIC that interacts with IKKα's coiled-coil domain, inhibits NF-κB activity, and suppresses tumor phenotypes through alternative splicing regulation.

The paper identifies six novel sequence motifs in lncRNAs that interact with multiple nuclear receptors and miRNAs, suggesting their role in gene regulation and evolutionary conservation.

The paper identifies an ultraconserved snoRNA-like element in the lncRNA CRNDE that promotes ribosome biogenesis and cell proliferation in renal cell carcinoma.

The paper evaluates expression changes of PVT1, HULC, and HOTTIP in DLBCL patients before and after treatment, finding significant upregulation pre-treatment and normalization post-treatment.

This study predicts and validates 320 lncRNAs in tamarind, analyzing their roles in gene regulation and biological pathways.

The paper creates a statistical genomics portrait of lncRNA genes for comparison with protein-coding genes to explore the non-coding genome.

The paper identifies inherited lncRNAs and circRNAs in zebrafish, finding that 20% of lncRNAs and 7% of circRNAs are inherited, with many conserved in mammals and expressed in adult tissues.

The paper identifies a long non-coding RNA, CyKILR, with two splice variants that have opposing effects on tumor growth and cell survival in NSCLC.

This study identifies lnc-FANCI-2 as a regulator of RAS signaling in HPV16-infected cervical cancer, showing its role in lesion progression and patient survival.

The paper identifies a new cancer-testis long noncoding RNA, OTP-AS1, which is antisense to the OTP gene and may regulate its expression in tumors.

This study identifies BRE-AS1's role in modulating inflammatory activation in THP-1 cells via the miR-30b-5p/SOC3/JAK2/STAT3 pathway, showing its impact on cytokine production and signaling.

The paper identifies and functionally characterizes lncRNAs involved in human monocyte-to-macrophage differentiation using RNA-seq and high-throughput screening.