Glycosylation and Glycoproteins Research

This study identifies glycoRNA-L and glycoRNA-S as mediators of human monocyte adhesion through binding to Siglec-5, with distinct glycan compositions and tissue expression patterns.

This study reveals the conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis using crystal structures and molecular simulations.

The paper presents an ultradeep N-glycoproteome atlas of mouse tissues, revealing spatiotemporal patterns of glycosylation in brain aging and neurodegenerative diseases.

This study identifies 16 new genetic loci associated with plasma N-glycosylation in 10,000 individuals and links them to liver disease and inflammatory proteins.

This study characterizes T cell glycosylation patterns across mouse and human tissues, revealing species-specific differences in glycan profiles and dynamics.

This study characterizes the sialome of the human retina and identifies alterations in age-related macular degeneration (AMD) that may impact complement factor H binding.

The paper introduces GAP-MS to study glycan-dependent PPIs and shows it identifies PPI variations under different glycosylation conditions.

LM-GlycoRepo Version 1.0 is a repository for mouse tissue glycome mapping data that supports FAIR principles and includes an embargo system and visualization tool.

The paper develops a systems model of MUC1 glycosylation and immune interactions in Luminal A breast cancer, showing that sialyltransferase inhibition reverses cancerous signaling.

This study investigates the role of an N-glycan-dependent ERQC system in C. neoformans, showing its impact on virulence, cell surface organization, and extracellular vesicle transport.

This study identifies Mgat4b as a regulator of melanocyte development and melanoma progression through N-glycosylation, showing its role in cell migration, adhesion, and tumor initiation.

The paper introduces glycan analysis probes (GAPs) inspired by human lectins to study host-microbe interactions and glycan-mediated processes.

The paper identifies NXPE1 as a gene responsible for sialic acid O-acetylation in the human colon, linking it to mPAS staining differences through genetic and functional analyses.

This study investigates the functional impact of SLC35A2 loss of function variants on glycomic signatures, neuronal fate, and network dynamics using human induced pluripotent stem cell-derived neurons.

The paper integrates N-glycan analysis with CODEX imaging to identify cell-specific glycosylation patterns in healthy human lung tissue.

This study shows water-mediated interactions between neutral N-glycans are weakly repulsive and long-ranged, with decay following a logarithmic pattern.

This study shows that downregulating CeEngase in C. elegans enhances its adaptability to heat and osmotic stress.

The paper identifies glycosylation of serine/threonine-rich IDRs in streptococcal membrane proteins and shows its role in biofilm formation.

This study characterizes the molecular structure and enzymatic mechanism of GLT25D1/COLGALT, identifying its catalytic site and dimeric assembly as critical for collagen lysine modification.

This study shows that reducing O-GlcNAcylation enhances etoposide-induced apoptosis in HepG2 cells via the p53/caspase-3/PARP1 pathway.

This study shows that a ketomimetic medium increases chemoresistance and invasiveness of breast cancer cells through hypersialylation and lipid synthesis pathways.

This study examines how sialylated glycans and molecular size of bovine submaxillary mucins affect influenza virus inhibition.

This study develops a high-throughput method to analyze site-specific N-glycosylation of fibrinogen in atrial fibrillation patients and identifies glycoforms associated with the condition.

This paper compares five glycoproteomic software tools using a tailored glycan database, finding that Protein Prospector has the highest agreement with known glycosites.

The paper evaluates the Orbitrap Astral mass spectrometer for plasma glycoproteome analysis, introducing nGlycoDIA to achieve high sensitivity and throughput.

The paper identifies NXPE1 as an acetyltransferase that modifies mucin glycans in colonic mucus, showing its role in modulating the mucus barrier against commensal microbes in ulcerative colitis.

This study identifies PDAC cancer cell subpopulations using multiplexed glycan immunofluorescence and shows consistent aberrant glycan signatures in both tumor and blood samples, improving detection beyond CA19-9 alone.

This study identifies glycoRNA as a novel component of the alveolar epithelial glycocalyx and shows its role in barrier regulation and viral infection.

This study creates glycoengineered CHO-Lec2 cells lacking B4GALT5 to study Shiga toxin receptors, finding they bind neither Stx1B nor Stx2B and show resistance to Stx1 holotoxin.