Neurogenesis and neuroplasticity mechanisms

The paper shows Prdm8 regulates the switch from motor neuron to oligodendrocyte production in zebrafish spinal cord by modulating Shh signaling.

This study investigates the connectivity dynamics between adult-born granule cells and inhibitory interneurons in the hippocampus, revealing distinct developmental patterns and functional roles.

This study investigates the combined effects of early life stressors on the nervous system using a multi-hit rat model and finds that multi-hit stress leads to greater neuronal impairments than single-hit stress.

This study identifies the Shh-Eya1 regulatory axis as critical for promoting symmetric cell divisions in cerebellar granule cell precursors by coordinating spindle orientation and cell fate determinants.

The paper quantifies progenitor and neuronal populations during mouse neocortex development and identifies polyploid neurons.

This study shows that loss of clustered protocadherin diversity disrupts the spatial arrangement of cortical interneuron subclasses.

This study shows that gsx2 mediates rostro-caudal positional signals to specify inferior olivary neurons from ptf1a-expressing progenitors in zebrafish.

The paper shows that post-embryonic zebrafish enteric neurogenesis occurs from Schwann cell precursors, not resident cells, and is enhanced by prucalopride.

This study identifies a SMAD1/5-YAP signaling module that regulates radial glia self-amplification and cortical growth during development.

The paper shows that the Lhx2-Ldb1 interaction is conserved in regulating hippocampal development and cell fate in mice.

The paper identifies NEUROD2's role in terminal neuron localization during cortical development and reveals its regulation of the Reln gene.

This study investigates how social defeat stress and fluoxetine treatment affect neurogenesis and behavior in ZnT3 knockout mice, finding no support for vesicular zinc's role in fluoxetine's behavioral benefits.

This study investigates the morphological changes during neurogenesis in human periodontal ligament stem cells, revealing transient nuclear lobulation not linked to proliferation and similar to in vivo neurogenic niches.

This study transplants human cortical neurons into mice to study their development and integration into mouse visual circuits, finding prolonged juvenile features and functional synaptic integration.

This study shows lithium treatment can reverse irradiation-induced impairments in hippocampal neurogenesis in mice even when started weeks after irradiation.

The paper identifies a preplate neuron stream that physically drives neocortical ventral expansion and somatotopic map formation through mechanical forces.

This study shows that ALK4 signaling integrates extracellular signals with intrinsic transcriptional programs to regulate the development of somatostatin interneurons in the cortex.

This study identifies multiple steps in spinal cord ventricular layer attrition during development, revealing heterogeneous cell origins and signaling pathway changes in the adult central canal.

This study characterizes the morphology and differentiation dynamics of cerebellar granule cell precursors in chick embryos, revealing complex mitotic behavior and early expression of differentiation markers.

The paper maps brain-wide afferent connectivity to oligodendrocyte precursor cells using monosynaptic tracing in adult mice, revealing extensive inputs from functionally interconnected cortical and thalamic regions.

This study shows that THRA mutations impair neural progenitor cell proliferation and organisation in human cortical development using patient-derived iPSCs.

The paper analyzes how hippocampal neurogenesis affects behavior by identifying key factors like baseline neurogenesis levels, inhibitory circuit efficiency, stimulus strength, and task accuracy requirements.

This study shows maternal inflammation impairs specific stages and subtypes of cortical GABAergic interneuron development, leading to structural and functional changes in the offspring's brain.

The paper shows that neurons born at the peak of development in the dentate gyrus die later in adulthood, while neurons born before or after are stable.

This study identifies RNF152 as a negative regulator of mTOR signaling in the floor plate, which blocks cell proliferation and controls cell number.

This study demonstrates high-efficiency in situ astrocyte-to-neuron conversion in adult mammalian brains to repair ischemic injury, generating sufficient new neurons to cover 40% of lost neurons and improve motor and memory function.

This study shows that Drosophila ClC-a chloride channels in glia of the neural stem cell niche are essential for neurogenic proliferation and proper axon guidance during nervous system development.

This study investigates the effects of KMT2D loss in brain cell development, finding precocious neuronal differentiation and disrupted oxygen responses in Kabuki syndrome models.

The paper investigates whether lineage regulates synaptic connectivity between olfactory sensory neurons and projection neurons in the mouse olfactory bulb, finding that lineage does not determine this connectivity.

This study shows that adult neurogenesis enhances efficient, nonspecific search strategies in a spatial alternation water maze task, particularly when platform locations alternate.