Neurogenesis and neuroplasticity mechanisms

Trisomy 21 Perturbs Oligodendrocyte Developmental States and Oligo-Neuron Communication in Human Forebrain Assembloids

This study investigates how trisomy 21 affects oligodendrocyte development and neuron-glia communication in human forebrain assembloids, finding a shift toward a pre-myelinating state and disrupted myelination.

Multimodal profiling and intersectional genetics reveal CA1 border inhibitory neuron diversity and postnatal emergence of retrosplenial connectivity

The paper identifies molecular and developmental diversity in CA1 border inhibitory neurons and shows their postnatal emergence of retrosplenial connectivity.

CDC25B couples ribosome biogenesis to cell cycle kinetics to promote spinal cord neurogenesis

The paper shows CDC25B promotes spinal cord neurogenesis by coordinating cell cycle progression with ribosome biogenesis, leading to increased translation in differentiating neurons.

Adolescent Sugar-Induced Miswiring of Hippocampal Neurons Drives Adult Motivational Dysfunction in rats

This study shows that adolescent sugar overconsumption disrupts hippocampal neuron function, leading to adult motivational issues in rats.

COG5-mediated Golgi organization coordinates neural progenitor fate during human brain development

This study shows that COG5 deficiency disrupts Golgi organization and affects neural progenitor fate during human brain development through altered trafficking and glycosylation.

An improved CRISPR-LICHT screen of 120 Tdark genes illuminates new biologically relevant SOX2 targets in human brain organoids

The paper uses CRISPR-LICHT to screen SOX2 targets in human brain organoids, identifying 28 new genes involved in neural progenitor lineage expansion and survival.

Select properties of supramammillary input to adult-born dentate gyrus neurons

This study identifies a distinct subpopulation of supramammillary nucleus neurons that provide inhibitory modulation to adult-born dentate gyrus neurons, enhancing pattern separation.

Dosage-dependent disruption of corticofugal neuron development by Fezf2 loss

This study quantifies the cell-type-specific and temporal transcriptional effects of Fezf2 dosage loss in mouse cortical development using single-cell RNA-seq and ATAC-seq data.

Classic and novel features of the dentate gyrus vascular niche quantified through 3D vessel reconstruction

The paper quantifies vascular features of the dentate gyrus using 3D imaging, revealing both known and novel aspects of vessel morphology in adult mice.

Activity-gated exocytosis drives myelin remodeling required for adult learning

This study identifies activity-dependent exocytosis in mature oligodendrocytes as a mechanism driving myelin remodeling necessary for adult learning.

A human model of the neurodevelopmental metabolic shift

This paper develops a human model system to study the neurodevelopmental metabolic shift by inducing neuronal differentiation with NGN2 and validating metabolic readouts.

THE BILE ACID RECEPTOR TGR5 MODULATES HIPPOCAMPAL NEURAL STEM CELL STATE AND AGEING

This study shows that TGR5 agonism expands hippocampal neural stem cells, reduces senescence, and improves cognitive function in aged mice without promoting neuronal differentiation.

Autonomous Dampening of Wnt Signaling Selects Zebrafish Spinal Cord Progenitors for an Oligodendrocyte Fate

The paper identifies pre-OPCs in zebrafish spinal cord and shows that Wnt signaling modulation influences oligodendrocyte fate through gene expression and chromatin accessibility.

Developmental rewiring of EHMT1 function during human cortical neurogenesis

This study shows EHMT1's functional rewiring during human cortical neurogenesis, revealing its shift from restraining pluripotency to supporting neuronal programs and its resilience to prolonged depletion.

Developmental prefrontal myelination shapes inhibitory interneuron function and adult social behavior

This study shows that disrupting developmental myelination in the medial prefrontal cortex impairs adult social behavior and PV interneuron function in mice, with parallels in human schizophrenia.

Dynamic Modulation of Neural Cell Identity Maintenance via Lysine Acetyltransferase Type 3 Protein Targeted Degradation

This study shows that KAT3 proteins are essential for maintaining neural cell identity, and their degradation or restoration affects transcriptome and physiological functions in neuronal and glial cells.

The olfactory ventricle: an overlooked and evolutionarily conserved feature of the mammalian brain

The paper identifies the olfactory ventricle as an ancestral and conserved feature in mammals, showing its persistence into adulthood and conserved cellular organization across species.

Intra-uterine position modulates lifelong hippocampal neurogenesis and anxiety-related behavior

This study shows that intra-uterine position affects lifelong hippocampal neurogenesis and anxiety-related behavior in mice by altering prenatal steroid exposure and neural development.

microRNAs control temporal patterning of the vertebrate nervous system

This study shows that microRNAs, specifically let-7 and miR-9 families, regulate the timing of neuronal identity transitions in the developing vertebrate nervous system by controlling temporal transcription factors.

Organoid-to-organoid transplantation and pro-neurogenic treatment promote graft integration and neuronal repair in a human ischemic model

This study shows that combining organoid transplantation with pro-neurogenic treatment improves graft integration and neuronal repair in a human ischemic model.

Cerebral organoids recapitulate interneuron chain migration in the human cortex

This study shows that long-term human cerebral organoids replicate postnatal interneuron migration, revealing chain migration and genetic factors linked to neurodevelopmental disorders.

Coordinated tri-inhibition generates human CA1, CA3 and DG neurons and hippocampal astrocytes forming long-lived and electrophysiologically complex cultures

This paper develops a differentiation protocol to generate human hippocampal neurons and astrocytes in vitro, demonstrating long-term viability and electrophysiological complexity.

The astrocytic secretome increases adult hippocampal neurogenesis and spatial memory in health and disease

This study shows that astrocytic secretome enhances adult hippocampal neurogenesis and spatial memory in healthy and disease models.

Presenilin-dependent ErbB4 Nuclear Signaling Regulates Astrogenesis via PARP1

The paper identifies a novel nuclear signaling pathway involving ErbB4 and PARP1 that regulates astrocyte differentiation during brain development.

Adaptive brain rewiring after brain injury via adult neurogenesis

This study shows that adult mice can reorganize brain circuits remotely after visual cortex injury, with adult neurogenesis contributing to functional recovery in olfactory processing.

An evolutionarily conserved interferon-responsive oligodendroglial state emerges during white matter aging

The paper identifies an interferon-responsive oligodendroglial state in aging white matter using killifish models, linking it to potential neurodegenerative disease mechanisms.

Morphological Hallmarks of White Matter Astrocytes Across Development

This study characterizes the morphological development of white matter astrocytes in mice, showing distinct developmental trajectories and structural features compared to gray matter astrocytes.

Multipotent radial glia sequentially deploy fate-restricted intermediate progenitors to diversify cortical interneurons

Fate mapping in mouse shows two separate MGE radial glia pools; the later pool uses temporal cohorts of fate-restricted basal intermediate progenitors to amplify and diversify cortical interneurons.

New cerebellar nuclei evolve through diversification of excitatory progenitors

The paper shows new cerebellar nuclei evolve through diversification of excitatory progenitors and spatial segregation, with inhibitory neurons incorporated later.

Conserved and divergent programs govern cerebellar output neuron development in zebrafish

This study identifies conserved and divergent developmental programs for cerebellar output neurons in zebrafish, showing shared origins with other vertebrates and unique mechanisms for eurydendroid cell organization.