Neurogenesis and neuroplasticity mechanisms

The paper constructs a gene regulatory network resource across species and brain regions to study neurogenesis dynamics and their links to neurodevelopmental disorders.

This study identifies basal fluidization in human neuroepithelia as a tissue-level mechanism driving forebrain expansion, distinct from other great apes and mice.

This study shows that STAU2 regulates human neurogenesis by affecting transcription factors, miRNA control, and progenitor maintenance, leading to changes in neural differentiation and organoid development.

This study shows that Mllt11 deficiency in hippocampal progenitors increases neurogenesis by altering radial glial morphology and expanding transit amplifying cells.

This study shows human brain organoids can mature over 5 years in culture, transcriptionally aging and retaining memory of time spent in vitro.

The paper shows that cortical layering in tetrapods follows conserved developmental principles, with mammals displaying an inverted layer order.

This study identifies YAP1's role in regulating oligodendrocyte-astrocyte fate switch and ependymal gene expression in adult spinal cord stem cells through in vitro experiments and multi-omic profiling.

This study identifies AGO1's role in neural progenitor cells in brain development and sociability through the LIN28A-REELIN axis, showing its impact on ASD-related phenotypes.

This study shows that PSA-MAP scaffolds enhance early neural regeneration after ischemic stroke by increasing progenitor cells and axonal content without significant changes in astrocytic or vascular coverage.

This study shows that hypoxic preconditioning of human iPSC-derived neural progenitor cells improves their survival and function after transplantation in a stroke mouse model.

This study shows that TS21 accelerates radial glia lineage progression, leading to premature production of inhibitory neurons and oligodendrocytes in Down syndrome.

The paper investigates miR155's role in hippocampal GABAergic neurogenesis in Alzheimer's disease, finding it regulates NSC dynamics and interneuron development with opposing effects compared to microglial miR155.

The paper investigates how altering cell size asymmetry in Drosophila neural stem cells affects their proliferation and lineage potential, finding increased stem cell pools but reduced lineage size and differentiation.

The paper identifies H3K27me3-mediated repression and -ketoglutarate as key regulators of species-specific neurogenesis timescales across mammals.

This study identifies cortical tension as a mechanical barrier that prevents premature neuronal differentiation during neurogenesis, showing that reducing it accelerates neuronal lineage commitment and differentiation.

This study characterizes adult hippocampal neurogenesis in AppKI mice, showing age-related deficits and environmental enrichment's protective effect.

This study inhibits QPRT in human stem cell-derived cerebral organoids, revealing altered cell type distribution and metabolic stress linked to neurodevelopmental disorders.

This study develops a method to generate neocortical organoids with distinct anterior-posterior molecular signatures and uses them to model Fragile X Syndrome pathology.

This study investigates functional neuronal regeneration after traumatic brain injury in killifish, showing that new neurons integrate into circuits and enable behavioral recovery over 50 days.

This study shows that species-specific fatty acid oxidation rates influence temporal patterning of corticogenesis through protein acetylation dynamics in human and mouse cortical progenitors.

This study shows transplanted human cortical neurons can integrate into and repair damaged motor circuits in ischemic mice by following transcriptional codes for axon guidance and synapse formation.

This study shows that NDE1 loss disrupts neural progenitor identity and forebrain patterning, leading to microcephaly through altered ERK signaling and regional identity shifts.

The paper shows that Wntless restricts Notch signaling to balance neuron and gliocyte generation in zebrafish dorsal diencephalon.

The paper investigates the geometric principles governing the morphology of oligodendrocyte precursor cells (OPCs) in the mouse corpus callosum using imaging and morphometric analysis.

This study identifies CCB79 as a primate-specific protein essential for maintaining neural progenitor diversity in developing brains by regulating ciliogenesis.

The paper investigates the spatial and temporal origins of interneuron subtypes in the caudal ganglionic eminence (CGE) and shows that specific subtypes arise from distinct CGE subdomains with stable spatial biases over time.

This study investigates the role of oligodendroglial ADAM10 in myelin development and maintenance, finding that its deficiency causes delayed oligodendrocyte maturation and myelin defects with sexual dimorphism in adult mice.

The paper shows safety learning in the infralimbic cortex recruits oligodendrocyte progenitor cells to PV interneurons, promoting PNN degradation and cognitive flexibility.

This study shows that methyl gallate improves post-stroke depression and cognitive impairments by enhancing hippocampal neurogenesis through PI3K/GSK3 and AMPK signaling.

This study investigates GPR17's role in oligodendrocyte precursor cell maturation and myelin regeneration, finding limited impact on myelin repair after injury.