Effects and risks of endocrine disrupting chemicals

Neonatal diethylstilbestrol exposure disrupts uterine epithelial apical-basal polarity and partial EMT state

This study investigates how neonatal exposure to diethylstilbestrol disrupts uterine epithelial polarity and partial EMT state in mice, leading to long-term functional impairments and cancer risk.

Bisphenol S causes deficits in social behaviour by disrupting serotonergic and BDNF-CREB1 signaling pathways

This study shows BPS exposure disrupts social behavior in zebrafish by altering serotonergic and BDNF-CREB1 pathways without significant oxidative damage.

Integrated proteomic and phosphoproteomic profiling reveals mechanisms of Bisphenol-A induced placental toxicity

This study identifies BPA-induced changes in placental phosphoproteome and kinase activity, revealing altered phosphorylation of c-JUN and GSK3 linked to placental toxicity and adverse pregnancy outcomes.

Effects of Phthalate Metabolite Mixture Exposure on Mouse Oocyte Development

This study shows that exposure to a phthalate metabolite mixture impairs mouse oocyte maturation and causes meiotic defects and DNA damage.

Late gestational exposure to flutamide alters stromal composition and immune landscape in the rat mammary gland during pre-puberty, peri-puberty, and adulthood

This study shows that prenatal exposure to flutamide alters mammary gland stromal composition and immune landscape in rats across multiple developmental stages.

Estrogenic Activity in Tampon Products

This study detects estrogenic activity in tampon extracts, identifying potential endocrine-disrupting chemicals that vary by brand.

The Placental Transcriptome Serves as a Mechanistic Link between Prenatal Phthalate Exposure and Placental Efficiency

This study identifies placental transcriptome genes and modules mediating the effect of prenatal phthalate exposure on placental efficiency and fetal growth.

An in utero exposure to the synthetic estrogen diethylstilbestrol affects the fat pad composition in post-natal mammary glands

This study shows that in utero exposure to diethylstilbestrol alters mammary gland stromal and immune features across development, leading to long-term changes in extracellular matrix and inflammation.

Human internal exposures of bisphenol A and six data-poor analogues predicted by physiologically based kinetic models with multimodal parameterization

The paper predicts internal exposures of bisphenol analogs using physiologically based kinetic models with multimodal parameterization, showing variability in concentrations by age, sex, and organ.

Effects of dibutyl phthalate (DBP) on life history traits and population dynamics of Daphnia magna: comparison of two exposure regimes

This study examines the effects of dibutyl phthalate (DBP) on Daphnia magna life history traits under two exposure regimes, finding that early embryonic exposure leads to significant impacts on survival, growth, and reproduction at low concentrations.

Bisphenol TMC disturbs mitochondrial activity and biogenesis, reducing lifespan and healthspan in the nematode Caenorhabditis elegans

This study shows that BPTMC exposure in C. elegans causes mitochondrial dysfunction, reduced lifespan, and healthspan, raising concerns about its safety as a BPA substitute.

Bisphenol A Disrupts Mitochondrial Functionality Leading to Senescence and Apoptosis in Human Amniotic Mesenchymal Stromal Cells

This study shows that BPA exposure impairs mitochondrial function in hAMSC, leading to oxidative stress, senescence, and apoptosis.

Oocyte exposure to low levels of triclosan has a significant impact on subsequent embryo physiology.

This study shows that low-dose triclosan exposure during bovine oocyte maturation impairs embryo development and metabolic function.

Environmentally-relevant doses of bisphenol A and S exposure in utero disrupt germ cell programming across generations resolved by single nucleus multi-omics

This study shows that prenatal exposure to BPA or BPS at environmentally relevant doses disrupts germ cell programming across generations, affecting sperm counts and transcriptional and epigenetic changes in mice.

In vitro to in vivo evidence for chemical disruption of glucocorticoid receptor signaling

This study identifies DDT and ziram as GR-disruptors in vitro and shows their in vivo effects on gene expression and immune cell populations.

Long-term dietary exposure to a mixture of phthalates enhances estrogen and beta-catenin signaling pathways, leading to endometrial hyperplasia in mice

This study shows that long-term exposure to a phthalate mixture in mice causes endometrial hyperplasia by enhancing estrogen and beta-catenin signaling pathways.

Interference with Systemic Negative Feedback Regulation as a Potential Mechanism for Nonmonotonic Dose-Responses of Endocrine-Disrupting Chemicals

This paper uses computational modeling to explore how endocrine-disrupting chemicals (EDCs) can produce nonmonotonic dose-response (NMDR) effects through interference with systemic negative feedback regulation.

Phthalates Impair Estrogenic Regulation of HIF2α and Extracellular Vesicle Secretion by Human Endometrial Stromal Cells

This study shows that phthalates disrupt estrogenic regulation of HIF2α and EV secretion in human endometrial stromal cells by altering DNA methylation and transcription factor binding.

Effects of organic and inorganic contaminants and their mixtures on metabolic health and gene expression in developmentally exposed zebrafish

This study evaluates the metabolic and gene expression effects of organic and inorganic chemical mixtures on zebrafish development, finding mixed additive and synergistic effects.

Phthalate exposure influences mating behavior and sperm morphology in an aquatic ecotoxicology model system

This study examines the effects of dimethyl phthalate exposure on male freshwater snails, finding reduced mating frequency and altered sperm morphology at high concentrations.

Cognitive effects of early life exposure to PCBs: Sex-specific behavioral, hormonal and neuromolecular mechanisms involving the brain dopamine system.

This study investigates sex-specific effects of early life PCB exposure on dopamine-related behaviors and neurochemistry in rats, revealing differences in estradiol and gene expression between males and females.

Phthalate monoesters affect membrane fluidity and cell-cell contacts in endometrial stromal cell lines

This study shows that phthalate monoesters alter membrane fluidity and disrupt cell-cell contacts in endometrial stromal cells.

Endocrine disruptor-induced epimutagenesis in vitro: Insight into molecular mechanisms

This study investigates how endocrine disruptors like BPS induce epimutations in different cell types and how these changes persist through cell differentiation and generations.

A common phthalate replacement disrupts ovarian function in young adult mice

This study shows that DEHTP and its metabolite MEHTP disrupt ovarian function in mice by altering follicle counts, hormone levels, and gene expression.

Mixtures of phthalates disrupt expression of genes related to lipid metabolism and peroxisome proliferator-activated receptor signaling in mouse granulosa cells

This study shows that phthalate mixtures alter gene expression in mouse granulosa cells, affecting lipid metabolism and PPAR signaling.

Common genetic variants associated with urinary phthalate levels in children: a genome-wide study

This study identifies genetic variants associated with urinary phthalate metabolite levels in children through GWAS and CNV analysis.

Postnatal maternal care moderates the effects of prenatal bisphenol exposure on offspring neurodevelopmental, behavioral, and transcriptomic outcomes

This study examines how prenatal bisphenol exposure interacts with postnatal maternal care to affect offspring neurodevelopment, behavior, and transcriptomic outcomes.

In-utero exposure to estrogen-mimicking bisphenols alters bone mineralization in the offspring

This study shows that in-utero exposure to low doses of bisphenol A and BPS increases bone mineral content and density in offspring rats by altering BMP/TGF-β1 signaling.

Placental Cell Conditioned Media Modifies Hematopoietic Stem Cell Transcriptome In Vitro

The paper investigates how placental cell conditioned media affects hematopoietic stem cell transcriptomes and how MEHP modifies these effects.

Machine learning identifies phenotypic profile alterations of human dopaminergic neurons exposed to bisphenols and perfluoroalkyls

This study uses machine learning to identify subcellular phenotypic changes in human dopaminergic neurons exposed to bisphenols and perfluoroalkyls, showing increased alpha-synuclein and decreased neurite length.