Retinal Development and Disorders

This study shows that Zfp36l1 and Zfp36l2 regulate retinal development by balancing proliferation and differentiation, with their loss causing reduced proliferation and increased differentiation in the retina.

This study identifies Edn2 upregulation in Prom1-deficient mice and shows that endothelin receptor antagonists reduce retinal degeneration.

This study shows that inhibiting VCP activity rescues degenerating P23H rod cells and improves their function in retinal models of adRP.

This study shows that impaired light adaptation in diabetic mice is due to reduced dopamine D4 receptor sensitivity, not decreased receptor expression.

This study uses single-cell transcriptomics to show that ATOH7 and Neurog2 regulate human retinal progenitor states and neuroblast fate by modulating bHLH factor expression.

This study shows ATF6 is essential for human cone photoreceptor development and demonstrates that ATF6 activators can restore cone growth in patient-derived retinal organoids.

This study shows that chronic social stress affects retinal ERG responses differently in male and female mice, suggesting retinal activity as a potential biomarker for stress response.

The paper investigates the role of somatostatin signaling via Sstr2 in retinal neurogenesis using scRNA-Seq and in vivo experiments, finding it inhibits photoreceptor generation and affects progenitor dynamics.

The paper demonstrates that ectopic expression of chimeric rhodopsin in mice restores dim-light vision and prevents retinal degeneration.

This study identifies the retinal circuits responsible for the pupillary light response (PLR) in mice, showing that rods, not cones, drive the PLR across light intensities.

This study shows that dendrimer-targeted immunosuppression of microglia accelerates photoreceptor regeneration in zebrafish retinas.

This study reprograms retinal interneurons into functional retinal ganglion cells in adult mice, demonstrating potential for vision restoration in diseases like glaucoma.

This study revives light-evoked neuronal signals in postmortem mouse and human retinas, showing that cone photoreceptor responses can be restored up to 5 hours postmortem, with hypoxia being the main cause of irreversible signal loss.

The paper analyzes integrin expression in primary rat RPE cells and the human ARPE-19 cell line using immunochemistry, finding that both express integrins, with ARPE-19 increasing expression after long-term culturing.

This study identifies Tbr2-expressing retinal ganglion cells as intrinsically photosensitive RGCs and shows Tbr2 regulates Opn4 transcription for ipRGC development and maintenance.

The paper identifies BBS2 mutations causing retinitis pigmentosa in a family and shows their effect on ciliary localization and zebrafish retinal phenotypes.

This study shows that AMPK regulates retinal metabolism and that its loss leads to photoreceptor and RPE cell degeneration.

The paper identifies a novel missense mutation E585K in RPGR that affects RNA splicing patterns, leading to reduced splicing diversity and potentially explaining slow disease progression in RP patients.

The paper identifies a new retinal interneuron type, the Campana cell, that integrates rod and cone input and has features of both bipolar and amacrine cells.

The paper identifies loss of lateral inhibition as a mechanism reducing visual function in macular degeneration and suggests modulating this inhibition could improve vision.

This study investigates the role of 2δ-3 in mouse retinal ganglion cells, finding subtle changes in visual responses under low and moderate light levels but normal optokinetic reflexes.

This study shows that skipping exon 13 of the USH2A gene produces functional Usherin protein in mice, supporting exon-skipping as a therapeutic approach for USH2A-related diseases.

This study uses iPSC-RPE models to evaluate gene augmentation and editing for Best disease, finding that some mutations respond to gene therapy while others require genome editing.

This study shows that MSI1 and MSI2 are essential for photoreceptor morphogenesis, contrasting their known role in stem cell maintenance.

The paper identifies transient cell clusters in the neonatal mouse retina associated with cholinergic wave activity during retinal development.

This study uses GWAS to identify Mendelian and non-Mendelian variants associated with retinitis pigmentosa, uncovering new genetic causes and therapeutic targets.

The paper identifies four functionally distinct retinal ganglion cell types labeled by the Sst-Cre mouse line, showing two have unique visual response properties.

This study shows that loss of Nhs in zebrafish and Xenopus leads to small eye size due to reduced proliferation, linked to increased Δ113p53 and its target genes.

The paper shows UV-cones in larval zebrafish are tuned for UV-bright prey capture through regional boosts in detection efficiency and synaptic calcium baseline.

The paper shows that epigenetic changes allow some photoreceptor cells to survive longer during retinal degeneration in Spata7 mutant mice.