Neurological disorders and treatments

Motor learning leverages coordinated low-frequency cortico-basal ganglia activity to optimize motor preparation in humans with Parkinson's Disease

This study investigates how motor learning in Parkinson's Disease patients involves coordinated low-frequency cortico-basal ganglia activity to optimize preplanning of motor sequences.

Rhythmic modulation of subthalamo-pallidal interactions depends on synaptic rewiring through inhibitory plasticity

This paper shows that rhythmic stimulation of STN and GPe can modulate pathological synaptic connectivity through inhibitory plasticity, reducing excessive beta oscillations in Parkinson's disease models.

Modulation of premotor cortex excitability mitigates the behavioral and electrophysiological abnormalities in a Parkinson's Disease Mouse Model

This study investigates how modulating premotor cortex excitability through deep brain stimulation alleviates motor symptoms in a Parkinson's Disease mouse model by targeting hyperexcitability in M2-STN synapses.

Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease

This study identifies how dopamine and deep brain stimulation affect cortex-basal ganglia networks at different scales, showing distinct mesoscale effects and shared macroscale suppression of network synchrony.

Spike-phase coupling of subthalamic neurons to posterior opercular cortex predicts speech sound accuracy

The paper shows that spike-phase coupling between subthalamic nucleus neurons and posterior opercular cortex predicts speech sound accuracy during speech production.

Integration of Nanomaterials and DBS to Improve Basal Ganglia Oscillations Using Delayed Van der Pol Model

This study combines nanomaterials with deep brain stimulation (DBS) using a Van der Pol delay model to improve basal ganglia oscillations and reduce pathological activity.

Differential Effects of Short-term and Long-term Deep Brain Stimulation on Striatal Neuronal Excitability in a Dystonia Animal Model

This study compares short-term and long-term effects of deep brain stimulation on neuronal excitability and synaptic transmission in a dystonia animal model, revealing distinct mechanisms and implications for treatment optimization.

Gamma oscillations in basal ganglia stem from the interplay between local inhibition and beta synchronization

This study identifies two distinct gamma rhythms in the basal ganglia using a spiking network model and shows their modulation in Parkinson's disease conditions.

Calcium-Based Synaptic and Structural Plasticity Link Pathological Activity to Synaptic Reorganization in Parkinson's Disease

This study uses a computational model to show how calcium-based synaptic and structural plasticity contribute to synaptic reorganization and abnormal activity in Parkinson's disease following dopamine depletion.

Oscillatory coupling between thalamus, cerebellum and motor cortex in essential tremor

This study shows that essential tremor is linked to increased oscillatory coupling at tremor frequency in a cerebello-thalamo-cortical network, with coupling strength correlating with tremor severity.

Essential Tremor Disrupts Rhythmic Brain Networks During Naturalistic Movement

This study identifies disruptions in rhythmic brain networks in essential tremor patients during naturalistic movement, linking altered network engagement to motor deficits and tremor severity.

Mixed Selectivity of Subthalamic Nucleus Neurons in Encoding Motor and Reward Behaviors

This study investigates how STN neurons encode motor and reward behaviors through mixed selectivity, revealing distinct encoding properties compared to the zona incerta.

Axonal pathology differentially affects human Purkinje cell subtypes in the essential tremor cerebellum

The paper identifies distinct Purkinje cell subtypes in the human cerebellum and shows differential vulnerability in essential tremor, with motor-related subtypes showing axonal pathology.

Cortical Acetylcholine Response to Deep Brain Stimulation of the Basal Forebrain

This study examines how different DBS parameters affect cortical acetylcholine levels and shows that peak responses are insensitive to frequency but increase with longer stimulation and donepezil treatment.

Subthalamic Signature of Freezing of Gait in Parkinson Disease

This study identifies distinct STN activity patterns associated with FOG predisposition and occurrence in PD patients, highlighting differences in beta band activity across STN regions.

The role of STN beta oscillations on lower extremity muscle activity in Parkinsonian stepping

This study examines how STN beta oscillations relate to lower limb muscle activity during stepping in Parkinson's patients, finding distinct beta patterns and levodopa effects on motor control.

Modulations of thalamo-cortical coupling during voluntary movement in patients with essential tremor

This study examines thalamo-cortical coupling during voluntary movement in essential tremor patients, finding frequency-specific changes in coherence and power related to motor control.

Transcriptomic disruption and functional hypoactivity in DYT-SGCE MGE-patterned inhibitory neurons

This study investigates SGCE mutations' impact on MGE-derived inhibitory neurons, finding transcriptomic dysregulation and functional hypoactivity, contrasting with hyperexcitability in glutamatergic neurons.

Stimulation of the Medial SNr Promotes Sustained Motor Recovery and Counteracts Parkinsonian Pathophysiology in Dopamine Depleted Mice

This study shows that stimulating specific neurons in the SNr of dopamine-depleted mice leads to sustained motor recovery and reduced parkinsonian symptoms, while global SNr inhibition only provides temporary effects.

Neural Interoceptive Processing is Modulated by Deep Brain Stimulation for Treatment Resistant Depression

This study examines how deep brain stimulation affects interoceptive processing in treatment-resistant depression patients using EEG and HEP measurements.

Beta burst characteristics and coupling within the sensorimotor cortical-subthalamic nucleus circuit in Parkinson's disease

The paper analyzes beta burst characteristics and coupling between sensorimotor cortical and subthalamic nucleus (STN) regions in Parkinson's disease patients during naturalistic behaviors.

Lower-Limb Muscle Synergies in Musician's Dystonia: A Case Study of a Drummer

This study analyzes lower-limb muscle synergies in a drummer with musician's dystonia using NMF, finding changes in spatial and temporal modules of muscle activity.

Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum

This study investigates the role of arkypallidal neurons in the external globus pallidus in mediating inhibitory control by modulating competition in the striatum through a biologically-constrained spiking model.

Projections between the globus pallidus externa and cortex span motor and non-motor regions

The paper identifies two distinct electrophysiological and molecular phenotypes of pallidocortical neurons projecting to motor and non-motor cortical regions, revealing a closed-loop circuit between the GPe and cortex.

Using a Deep Learning Approach for Model-based Control of Deep Brain Stimulation

This paper develops a 1-D CNN for decoding DBS-induced neural activity to predict EMG signals, achieving high accuracy compared to polynomial and LSTM methods.

Beyond the CTCT: Remote Structural Changes After VIM-MRgFUS in Essential Tremor

This study examines structural brain changes after VIM-MRgFUS treatment for essential tremor, finding remote gray matter volume changes and associations with motor and quality of life improvements.

Striatal cell-type-specific molecular signatures reveal therapeutic targets in a model of dystonia

The paper identifies cell-type-specific molecular changes in dystonia by analyzing translatomes of dSPNs and iSPNs in DRD mice, revealing glutamatergic signaling disruptions and identifying LRRK2 inhibition as a therapeutic target.

A Method for Electrical Stimulus Artifact Removal Exploiting Neural Refractoriness: Validation by Contrasting Cathodic and Anodic Stimulation

This paper introduces a method to remove electrical stimulus artifacts by exploiting neural refractoriness, showing distinct neural responses to cathodic and anodic stimulation.

Cerebellar deep brain stimulation as a dual function therapeutic for restoring movement and sleep in dystonic mice

This study shows cerebellar deep brain stimulation improves both motor and sleep symptoms in dystonic mice.

Cross-species brain-wide mapping reveals a conserved and coordinated network engaged by NAc DBS

This study maps the brain-wide network activated by NAc DBS in mice and finds similar connectivity patterns in humans, suggesting conserved mechanisms across species.