Escherichia coli research studies

The paper estimates the basic reproduction number (R0) for pandemic E. coli clones and finds that ST131-A has an R0 comparable to pandemic influenza viruses.

This study links bacterial warfare via bacteriocins to virulence and antimicrobial resistance in E. coli, showing their association with pathogenic strains and horizontal gene transfer.

The paper presents the first complete structural model of the HlyA T1SS using cryo-EM and SAXS, revealing CLD domain dynamics and toxin binding mechanisms.

This study identifies enhanced virulence and stress tolerance as factors contributing to the epidemiological success of Shigella sonnei, using zebrafish models and genomic analysis.

The paper introduces a platform using Citrobacter rodentium to generate antibodies against bacterial polysaccharides and proteins without requiring purified or synthetic antigens.

This paper introduces nine oligonucleotides and a Python tool for in silico and in vitro typing of E. coli LPS outer core structures, revealing hybrid types and associations with pathogenicity and phylogeny.

The paper constructs genome-scale metabolic models for APEC phylogroups B2, C, and G, identifying a lineage-specific metabolic pathway in phylogroup C that distinguishes it from other groups.

This study shows uropathogenic E. coli forms cocci inside host cells through FtsZ-driven division, revealing a new level of bacterial morphological plasticity.

This study identifies macrophages, not neutrophils, as key in controlling Shigella through TLR-induced IL-12 and IFN-γ in a mouse model of shigellosis.

This study compares phenotypic differences among high-risk APEC clonal groups in vitro and in vivo, finding variation in invasion, survival, and virulence.

This study shows that IpaC forms a translocation-competent pore essential for Shigella flexneri to escape double membrane vacuoles during intercellular spread.

This paper introduces a PCR-based method to measure bacterial growth rates during infection, showing it correlates with WGS-based methods and reveals UPEC growth dynamics in a mouse UTI model.

The paper identifies convergent evolution of D-ribulose utilisation pathways in attaching and effacing pathogens, showing how EHEC and Citrobacter rodentium exploit this nutrient for gut colonization.

This paper determines the structure of lymphostatin, a multifunctional virulence factor in E. coli, revealing its domains and mechanism of action.

This paper identifies AtlE, an N-acetylmuramidase essential for virulence in E. faecalis, showing its role in cell wall remodelling and immune evasion via the release of EPA-containing fragments.

This study analyzes T6SS distribution in 131,610 E. coli genomes, revealing subclass prevalence, associations with pathotypes, and relationships with virulence and resistance genes.

This study identifies LDLR-mediated clathrin-dependent endocytosis as the mechanism by which HlyA from UPEC causes renal epithelial toxicity.

This study compares the growth and protein expression of non-O157 STEC serotypes and non-STEC E. coli in bovine rumen environments under different dietary conditions.

This paper shows that ME0054 disrupts AdhE spirosomes, enhancing ethanol-to-acetyl-CoA conversion and altering T3SS expression in EHEC.

This study compares Salmonella and Shigella colonization strategies in human enteroids and colonoids, identifying distinct virulence factor modules that drive divergent infection kinetics and epithelial colonization patterns.

This paper presents cryo-EM structures of engineered Shiga toxin-based immunogens that stabilize pentamers and show interaction with neutralizing antibodies, supporting their use in a vaccine for STEC-HUS.

The paper characterizes a new Escherichia cryptic clade IV strain from an urban stream, revealing genomic features linked to environmental adaptation and ecological origin.

This study identifies PIK3C3 as essential for Shigella flexneri cell-to-cell spread by facilitating vacuole formation through PtdIns(3)P accumulation and Dynamin 2 recruitment.

This study shows that parenteral vaccination with recombinant EtpA glycoprotein can protect against ETEC intestinal colonization in mice, with protection dependent on vaccination schedule and adjuvant type.

This study identifies mechanoporation via the Type Three Secretion System as a mechanism by which Shigella flexneri breaches vacuolar membranes to access the cytosol.

This study examines genotype dependence of virulence-associated genes in ESBL-producing E. coli from UTI patients, finding ST131 strains show distinct virulence gene repertoires and lower sepsis rates.

The paper identifies extraintestinal pathogenic Escherichia coli, Enterococcus faecalis, and Streptococcus gallolyticus as potential causative agents of exudative cloacitis in kakapos through metatranscriptomic analysis of lesions and cloacal swabs.

This study uses a CRISPRi screen to identify genes in Salmonella Typhimurium that affect multicellular aggregate formation in response to Sal4 IgA, revealing a role for Type 1 Fimbriae in evading antibody-mediated agglutination.

This study shows that the wzxE flippase is essential for E. coli survival under low pH, low temperature, and high osmotic stress by suppressing the negative effects of ECA intermediates.

This study shows Shigella flexneri uses IpaH1.4 to degrade RNF213 and prevent LPS ubiquitylation, evading host antibacterial autophagy.