Ultrasound and Hyperthermia Applications

Long Term Study of Motivational and Cognitive Effects of Low-intensity Focused Ultrasound Neuromodulation in the Dorsal Striatum of Nonhuman Primates

Neuronal responses to focused ultrasound are gated by pre-stimulation brain rhythms

This study shows that amplitude-modulated tFUS reduces neuronal firing rate, while continuous-wave tFUS increases it, with effects influenced by baseline brain rhythms.

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

The paper demonstrates that pre-incubating BBB models with claudin-5 binders enhances FUS-mediated BBB opening, allowing lower acoustic pressures and improved permeability.

Mechanics Of Ultrasonic Neuromodulation In A Mouse Subject

This study investigates the mechanics of ultrasound neuromodulation in mice, finding that off-target sensory effects depend on frequency and that the vertebral column acts as a waveguide for shear waves.

Circuit-specific sonogenetic stimulation of the deep brain elicits distinct signaling and behaviors in freely moving mice

This study demonstrates that sonogenetics can selectively activate defined neural circuits and induce specific behaviors in freely moving mice through ultrasound stimulation.

ASIC1a is required for neuronal activation via low-intensity ultrasound stimulation in mouse brain

This study shows low-intensity ultrasound activates mouse brain neurons via ASIC1a and mechanotransduction, leading to neurogenesis and suggesting therapeutic potential.

Transcranial Focused Ultrasound Neuromodulation of the Thalamic Visual Pathway in a Large Animal Model

This study uses MR-guided TUS to modulate visual evoked potentials and cortical oscillations in a sheep model by targeting the lateral geniculate nucleus.

Mechanistic modeling suggests that low-intensity focused ultrasound can selectively recruit myelinated or unmyelinated nerve fibers

This paper models low-intensity focused ultrasound's ability to selectively recruit myelinated or unmyelinated nerve fibers through parametric sub-spaces and membrane electromechanical coupling differences.

Nitrous Oxide Enhances Focused Ultrasound Mediated Delivery of Viral Gene Therapy

Nitrous Oxide reduces microbubble and ultrasound pressure requirements for BBB opening and improves AAV9 vector delivery.

TUSX: an accessible toolbox for transcranial ultrasound simulation

TUSX provides an open-source MATLAB toolbox for transcranial ultrasound simulation using subject-specific medical images and validates it with water tank pressure measurements.

Pulsed Focal ultrasound as a non-invasive method to deliver exosomes in the brain/stroke

This study demonstrates that pulsed focused ultrasound can deliver exosomes to stroke areas without damaging brain structures when nanobubbles are not used.

Sonogenetics for noninvasive and cellular-level neuromodulation in rodent brain

This paper demonstrates that TRPV1 can be used for noninvasive, cell-type specific, and spatiotemporally controlled modulation of mammalian brain activity using focused ultrasound.

Real Time and Delayed Effects of Subcortical Low Intensity Focused Ultrasound

This study uses low-intensity focused ultrasound to modulate deep brain structures and observes changes in BOLD signal and perfusion using functional MRI.

Differential effects of amplitude-modulated transcranial focused ultrasound on excitatory and inhibitory neurons

This study shows that amplitude-modulated transcranial focused ultrasound (AM-tFUS) differentially affects excitatory and inhibitory neurons in the rat hippocampus based on intensity.

Ultrasound neuromodulation through nanobubble-actuated sonogenetics

This paper demonstrates a method using gas-filled nanostructures to enhance and selectively control ultrasound neuromodulation of neurons.

Transcranial Focused Ultrasound Neuromodulation of Voluntary Movement-related Cortical Activity in Humans

This study uses transcranial focused ultrasound to enhance voluntary movement-related cortical activity in humans by modulating the movement-related cortical potential.

Spike-frequency dependent inhibition and potentiation of neural activity by ultrasound

This study shows ultrasound can inhibit or potentiate firing in hippocampal neurons depending on firing frequency, explained by increased potassium conductance.

Transcranial ultrasound stimulation in humans is associated with an auditory confound that can be effectively masked

This study shows that transcranial ultrasound stimulation (TUS) produces audible sounds in humans that can be masked by concurrent audio signals.

Focused ultrasound excites neurons via mechanosensitive calcium accumulation and ion channel amplification

This study identifies the mechanism by which focused ultrasound excites neurons through mechanosensitive calcium channels and ion channel amplification.

Focused ultrasound blood brain barrier opening mediated delivery of MRI-visible albumin nanoclusters to the rat brain for localized drug delivery with temporal control

This paper demonstrates a method for noninvasive, temporally controlled drug delivery to the rat brain using focused ultrasound and MRI-visible albumin nanoclusters.

Transcranial Pulse Stimulation with Ultrasound in Alzheimer’s disease – A new navigated focal brain therapy

This study introduces transcranial pulse stimulation (TPS) for Alzheimer’s disease, showing improved neuropsychological scores and increased memory network connectivity.

Transcranial ultrasound selectively biases decision-making in primates

This study shows transcranial ultrasound can bias decision-making in non-human primates by modulating oculomotor circuits, with effects comparable to neuromodulatory drugs.

Intrinsic Cell-type Selectivity and Inter-neuronal Connectivity Alteration by Transcranial Focused Ultrasound

This study shows tFUS selectively affects excitatory and inhibitory neurons and induces long-term synaptic changes in rats.

Elimination of peripheral auditory pathway activation does not affect motor responses from ultrasound neuromodulation

This study shows that motor responses from ultrasound neuromodulation are not caused by peripheral auditory pathway activation, using deaf mice and modified ultrasound stimuli.

Manipulation of subcortical and deep cortical activity in the primate brain using transcranial focused ultrasound stimulation

This study uses transcranial focused ultrasound to manipulate activity in deep brain regions of macaques and assesses its effects using fMRI.

Offline impact of transcranial focused ultrasound on cortical activation in primates

This paper demonstrates that transcranial focused ultrasound induces sustained, reversible neural modulation in primate brains, altering connectivity patterns in targeted regions.

Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI

This study examines the effects of transcranial focused ultrasound on human motor cortex using 7T fMRI, finding increased activation volume in targeted finger representations without effects on connected regions.

Acoustically Targeted Chemogenetics for Noninvasive Control of Neural Circuits

This paper introduces a noninvasive method to control specific neural circuits using acoustically targeted chemogenetics, demonstrating its ability to modulate hippocampal neurons and affect memory formation in mice.

Transcranial focused ultrasound neuromodulation of the human primary motor cortex

This study investigates the effects of transcranial focused ultrasound on human motor cortical excitability and behavior, finding inhibition of motor evoked potentials and reduced reaction times.

Non-invasive ultrasonic modulation of visual evoked response by GABA delivery through the blood brain barrier

This study shows that non-invasive ultrasound can deliver GABA to the visual cortex of non-human primates, reducing visual evoked activity, with GABA inhibition being more impactful than BBB disruption.