Ultrasound and Hyperthermia Applications

Heterogeneous Kinetics of Nanobubble Ultrasound Contrast Agent and Angiogenic Signaling in Head and Neck Cancer

The paper analyzes nanobubble ultrasound contrast agent kinetics and angiogenic signaling in head and neck cancer using pixel clustering and proteomics.

Focused ultrasound enhanced antibody delivery for the treatment of Parkinson's Disease

This study evaluates the feasibility of using focused ultrasound to deliver an anti-alpha-synuclein antibody to Parkinson's disease mouse models, showing successful BBB opening and antibody delivery.

Focused Ultrasound Augments the Delivery and Penetration of Model Therapeutics into Cerebral Cavernous Malformations

This study evaluates how focused ultrasound enhances drug delivery into cerebral cavernous malformations using contrast agents in a mouse model.

Ultrasound pulse repetition frequency preferentially activates different neuron populations independent of cell type

The paper shows that different ultrasound pulse repetition frequencies selectively activate distinct neuron populations in the mouse motor cortex, independent of cell type.

Single cell RNA-sequencing reveals GINIP-expressing neurons as the main targets of focused ultrasound

The paper uses single-cell RNA sequencing to identify GINIP-expressing neurons as the main targets of focused ultrasound in DRG neurons.

Transcranial focused ultrasound activates feedforward and feedback cortico-thalamo-cortical pathways by selectively activating excitatory neurons

This study shows that tFUS selectively activates excitatory neurons in the cortico-thalamo-cortical pathway, modulating feedforward and feedback loops between brain regions.

An Investigation of Parameter-Dependent Cell-Type Specific Effects of Transcranial Focused Ultrasound Stimulation Using an Awake Head-Fixed Rodent Model

This study investigates cell-type specific effects of tFUS in awake rats, finding that PRF and DC sensitivity persists despite some differences compared to anesthetized conditions.

Mild Hyperthermia Enhanced Liposomal Doxorubicin Delivery and CD8+ T cell Infiltration in Triple Negative Breast Cancer

This study shows that mild hyperthermia enhances liposomal doxorubicin uptake and CD8+ T cell infiltration in 4T1 tumors.

50-nm gas-filled protein nanostructures to enable the access of lymphatic cells by ultrasound technologies

This paper introduces 50-nm gas-filled protein nanostructures that can traverse biological barriers and access lymphatic cells via ultrasound technologies.

Low-intensity focused ultrasound to the human insular cortex differentially modulates the heartbeat-evoked potential: a proof-of-concept study

This study uses LIFU to target brain regions involved in the HEP and finds that PI modulation decreases HEP amplitudes.

Truly tiny acoustic biomolecules for ultrasound imaging and therapy

This paper introduces bicones, tiny acoustic contrast agents based on gas vesicles, showing their effectiveness in imaging and therapy through ultrasound.

A patient-derived amyotrophic lateral sclerosis blood-brain barrier cell model reveals focused ultrasound-mediated anti-TDP-43 antibody delivery.

This study develops a human ALS patient-derived BBB model to show focused ultrasound with microbubbles enhances anti-TDP-43 antibody delivery across the BBB in vitro.

Focused ultrasound increases gene delivery to deep brain structure following the administration of a recombinant adeno-associated virus in the cerebrospinal fluid

This study shows focused ultrasound enhances gene delivery to deep brain structures when recombinant adeno-associated virus is administered in the cerebrospinal fluid.

Transcranial Focused Ultrasound Remotely Modulates Extrastriate Visual Cortex with Subregion Specificity

This study shows that transcranial focused ultrasound can modulate activity in the extrastriate visual cortex with subregion specificity when targeting the prefrontal cortex in rhesus macaques.

A Simulation Study on High Spatio-Temporal Resolution Acousto-Electrophysiological Neuroimaging

This study simulates acousto-electrophysiological neuroimaging to assess its feasibility for high spatio-temporal resolution brain activity recording.

Gas vesicle-blood interactions enhance ultrasound imaging contrast

This study investigates how gas vesicles interact with blood components and shows that surface modifications can alter these interactions to improve in vivo performance.

Effects of focused ultrasound in a "clean" mouse model of ultrasonic neuromodulation

This study develops a mouse model to study focused ultrasound neuromodulation, showing reduced off-target effects and revealing non-auditory side effects at higher pressures.

Transcranial focused ultrasound-mediated neurochemical and functional connectivity changes in deep cortical regions in humans

Theta-burst transcranial ultrasound lowered GABA+ in the posterior cingulate but not dorsal anterior cingulate cortex in 24 adults, while raising resting-state connectivity of both targets.

Non-ablative disease-modifying effects of magnetic resonance-guided focused ultrasound in neuromelanin-producing parkinsonian rodents

Transcranial focused ultrasound reduces neuromelanin accumulation and provides therapeutic benefits in parkinsonian rats without additional interventions.

Non-invasive disruption of the blood-brain barrier in the marmoset monkey

This study demonstrates non-invasive blood-brain barrier disruption in marmosets using transcranial focused ultrasound with microbubbles, establishing safe and reliable parameters for preclinical applications.

Non-invasive modulation of the human dorsal anterior cingulate attenuates acute pain perception and homeostatic cardiovascular responses

This study uses low-intensity focused ultrasound to non-invasively modulate the dorsal anterior cingulate cortex, reducing pain perception and altering cardiovascular responses to heat pain.

Non-invasive neuromodulation of sub-regions of the human insula differentially affect pain processing and heart-rate variability

This study uses low-intensity focused ultrasound to non-invasively target specific sub-regions of the human insula, showing differential effects on pain perception and heart-rate variability.

The mechanosensitive ion channel Piezo1 contributes to ultrasound neuromodulation

This study shows that Piezo1 mediates ultrasound neuromodulation in the brain by demonstrating reduced neuronal responses in Piezo1 knockout mice.

Alteration of functional connectivity in the cortex and major brain networks of non-human primates following focused ultrasound exposure

This study compares the effects of focused ultrasound alone versus with microbubbles on functional connectivity in non-human primate brains.

Ramped V1 transcranial ultrasonic stimulation modulates but does not evoke visual evoked potentials

This study uses ramped transcranial ultrasonic stimulation to investigate its effects on visual evoked potentials, finding no direct evoked potentials but modulation of VEPs when combined with a checkerboard stimulus.

Modulation effect of non-invasive transcranial ultrasound stimulation in an ADHD rat model

This study shows that non-invasive transcranial ultrasound stimulation improves cognitive behavior and modulates neural activity in an ADHD rat model.

Controlled delivery of ultrasound through the head for effective and safe therapies of the brain

This paper develops a method to improve the effectiveness and safety of transcranial focused ultrasound by compensating for skull and scalp attenuation and distortion.

Sustained Modulation of Deep Brain Circuits with Focused Ultrasonic Waves

This study shows that transcranial focused ultrasound can safely and sustainably modulate deep brain circuits in awake non-human primates, affecting behavior and neural activity.

Remus: System for Remote Deep Brain Interventions

The paper introduces Remus, a remote ultrasound system for precise deep brain interventions, validated in non-human primates.

Ultrasound Neuromodulation and Correlation Change in the Rat Somatosensory Cortex

This study shows tFUS increases neural firing and induces frequency-dependent correlation changes in rat somatosensory cortex neurons.