3D Printing in Biomedical Research

Microfluidic Modulation of Microvasculature in Microdissected Tumors

This study develops a microfluidic platform to perfuse microdissected tumors, showing improved microvascular structure and CD31 expression compared to diffusive transport.

3D Printing of Multiscale Scaffolds with Microtopography for Guiding Tissue Organization and Regeneration

This paper introduces a 3D printing technique to create multiscale scaffolds with microtopography to guide tissue organization and regeneration.

Multicompartmentalized microvascularized tumor-on-a-chip to study tumor-stroma interactions and drug resistance in ovarian cancer

This paper develops a tumor-on-a-chip model to study ovarian cancer drug resistance by mimicking tumor-stroma interactions and compartmentalized microenvironment.

Machine Learning Driven Optimization for High Precision Cellular Droplet Bioprinting

The paper develops machine learning models to predict droplet volumes in bioprinting by optimizing parameters like viscosity and pressure, achieving precise volume control for biomedical applications.

Non-Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High-Content Imaging

This paper develops a mesofluidic bioreactor platform with high-content imaging for non-invasive quality control of brain organoids, improving their development and reducing cell death.

Organ Chips with integrated multifunctional sensors enable continuous metabolic monitoring at controlled oxygen levels

This paper introduces Organ Chips with integrated sensors for continuous metabolic monitoring under controlled oxygen levels, demonstrating functionality in human Gut and Liver Chip cultures.

Engineered microvasculature using maskless photolithography and on-chip hydrogel patterning: a facile approach

This paper describes a method to create microvasculature models using photolithography and hydrogel patterning, enabling rapid and tunable fabrication of perfusable vascular structures from stem cell-derived endothelial cells.

3D bioprinting of low-viscosity phase-separated food-grade bioinks by in situ self-assembly

This paper introduces a bioprinting method using in situ self-assembly to create food-grade 3D models that support myoblast differentiation and protein content increase.

Embedding bioprinting of low viscous, photopolymerizable blood-based bioinks in a self-healing transparent supporting bath

This paper introduces CLADDING, a bioprinting method using a self-healing transparent support bath to enable printing of low-viscosity protein-based bioinks with high cell viability.

A novel thin plate spline methodology to model tissue surfaces and quantify tumor cell invasion in organ-on-chip-models

The paper introduces a thin plate spline method to model tissue boundaries in organ-on-chip models and quantify tumor cell invasion.

Functional evaluation of microdissected tumor 'cuboids': a microscale ex vivo cancer model that retains a complex tumor microenvironment

The paper develops a microscale ex vivo cancer model using tumor cuboids that retain a complex tumor microenvironment, enabling drug and immunotherapy testing.

Computational Methods for Biofabrication in Tissue Engineering and Regenerative Medicine - a literature review

This paper reviews computational methods for biofabrication in tissue engineering and regenerative medicine, highlighting gaps in multi-stage and multi-component modeling.

Zonal Patterning of Extracellular Matrix and Stromal Cell Populations Along a Perfusable Cellular Microchannel

This paper develops a microphysiological system to spatially pattern ECM composition and stromal cells in a 3D microchannel, demonstrating spatial control of cell interactions and signaling gradients.

Investigating the impact of the interstitial fluid flow and hypoxia interface on cancer biology using a spheroid-on-chip perfusion system

This study uses a spheroid-on-chip system to analyze how interstitial fluid flow and hypoxia affect cancer gene expression and identifies potential biomarkers.

A methodology combining reinforcement learning and simulation to optimize the in silico culture of epithelial sheets.

This paper proposes a reinforcement learning-based method to optimize in silico protocols for simulating epithelial sheet fabrication.

Organs-on-a-Chip Database (OOCDB): A Comprehensive, Systematic and Real-time Organs-on-a-chip Database

The paper introduces OOCDB, a database that integrates organs-on-a-chip data and tools to enable searching, downloading, and analyzing organs-on-a-chip literature and data.

3D Bioprinting of Stem Cell-Derived Central Nervous System Cells Enables Astrocyte Growth, Vasculogenesis and Enhances Neural Differentiation/Function

This paper develops a 3D bioprinting platform using iPSC-derived CNS cells to create scalable, biomimetic cultures that support astrocyte growth, vasculogenesis, and enhanced neural differentiation.

Enhancing Precision in Bioprinting Utilizing Fuzzy Systems

The paper develops a fuzzy system to optimize bioprinting parameters for different bioinks, improving precision by 15-29% compared to manufacturer recommendations.

Programmable Microbial Ink for 3D Printing of Living Materials Produced from Genetically Engineered Protein Nanofibers

This paper develops a microbial ink for 3D printing living materials using genetically engineered E. coli cells that self-assemble into nanofiber networks capable of sequestering toxins and releasing biologics.

Rapid fabrication of hydrogel micropatterns by projection stereolithography for studying self-organized developmental patterning

The paper introduces a rapid hydrogel micropatterning method using projection stereolithography to study self-organized developmental patterning of human embryonic stem cells.