3D Printing in Biomedical Research

Anisotropic Articular Cartilage Biofabrication based on Decellularized Extracellular Matrix

This study develops a light-based bioprinting method using decellularized extracellular matrix to create anisotropic cartilage scaffolds that promote tissue maturation and mimic native structure.

Toxicokinetics for organ-on-chip devices

The paper develops a toxicokinetic model to measure and predict chemical-PDMS interactions in organ-on-chip devices, showing accurate dose prediction under continuous-flow conditions.

Capacity and limitations of microfluidic flow to increase solute transport in three-dimensional cell cultures

This study investigates how microfluidic flow parameters affect solute transport in 3D cell cultures, showing that chamber size, inlet velocity, and confinement influence solute distribution and penetration depth.

Accelerated maturation of branched organoids confined in collagen droplets

This study shows that pancreatic ductal adenocarcinoma cells in collagen droplets form branched organoids with complex morphology, suggesting accelerated maturation compared to traditional bulk culture.

Tuning the Mechanical Properties and Printability of Viscoelastic Skin-Derived Hydrogels for 3D Cell Culture

This study develops tunable porcine skin-derived hydrogels for 3D bioprinting, optimizing their mechanical properties and printability to support cellular growth and structure formation.

Gut-on-Chip Methodology Based on 3D-Printed Molds: A Cost-Effective and Accessible Approach

This paper presents a low-cost, open-access 3D-printed Gut-on-Chip method for gut research, demonstrating its functionality with Caco-2 cells.

Quantitative evaluation of the role of the microenvironment in the phenotype, metabolism, and drug resistance of PDAC tumor organoids

This study evaluates how scaffold composition affects PDAC organoid phenotype, metabolism, and drug resistance, finding that collagen-Matrigel mixtures best mimic invasive tumors.

A high-throughput 3D culture microfluidic platform for multi-parameter phenotypic and omics profiling of patient-derived organoids

This paper introduces a high-throughput microfluidic platform for organoid culture and multi-omics profiling, demonstrating its utility in clinical and drug discovery settings.

Enhanced Maturity and Functionality of Vascularized Human Liver Organoids through 3D Bioprinting and Pillar Plate Culture

This study enhances the maturity and functionality of liver organoids by combining 3D bioprinting with vascular progenitor cells and a pillar plate culture system.

An immunocompetent human kidney on-a-chip model to study renal inflammation and immune-mediated injury

This paper develops a 3D in vitro kidney model with immune cells to study inflammation and injury, showing monocyte migration and response to inflammatory stimuli.

Three dimensionally printed microstructured alginate scaffolds for neural tissue engineering

This paper presents 3D printed microstructured alginate scaffolds with tetrapod-shaped ZnO templates that enhance neuron adhesion and maturation.

Self-healing, biocompatible bioinks from self-assembled peptide and alginate hybrid hydrogels

This paper develops a hybrid bioink combining self-assembled peptides and alginate to create a stiff, printable, and self-healing material with improved biocompatibility for tissue engineering and biosensing.

Modeling vascular dynamics at the initial stage of endochondral ossification on a microfluidic chip using a human embryonic-stem-cell-derived organoid

This study develops a microfluidic chip model of endochondral ossification using human stem cell-derived organoids, showing vascular-like network formation and interactions.

A 3D-printed multi-compartment organ-on-chip platform with a tubing-free pump models communication with the lymph node

This paper develops a 3D-printed organ-on-chip platform with a tubing-free pump to model lymph node communication during vaccination.

Stochastic to Deterministic: A straightforward approach to create serially perfusable multiscale capillary beds

This paper develops a method to create serially perfusable multiscale capillary beds in vitro for studying vascular biology and integration into organoid and organ-on-a-chip models.

Geometrically-engineered organoid units and their assembly for pre-construction of organ structures

This study develops a method to fabricate and assemble organoid units for creating larger, transplantable organ-like structures.

4D bioprinting shape-morphing tissues in granular support hydrogels: Sculpting structure and guiding maturation

This paper introduces a 4D bioprinting platform that enables programmable shape-morphing of tissues through viscoelastic hydrogels, enhancing structural and functional properties of iPSC-derived heart tissues.

Soft-lithographically defined template for arbitrarily patterned acoustic bioassembly

This paper introduces a soft-lithography-based acoustic bioassembly technique to create complex multicellular structures with functional liver tissue mimic capabilities.

High-Throughput Bioprinting of Spheroids for Scalable Tissue Fabrication

This paper introduces HITS-Bio, a high-throughput spheroid bioprinting system that enables scalable tissue fabrication with high cell viability and speed.

Clickable PEG-norbornene microgels support suspension bioprinting and microvascular assembly

This study develops clickable PEGNB microbeads that enable suspension bioprinting and microvascular self-assembly for engineering hierarchical vasculature.

Tumoroid-on-a-Plate (ToP): Physiologically Relevant Cancer Model Generation and Therapeutic Screening

This study introduces a 3D tumor model called ToP for generating predictive cancer models and screening therapeutics for glioblastoma and pancreatic adenocarcinoma.

Human Stem Cell-derived Kidney Collecting Duct Model via Epithelial Microphysiological Analysis Platform: Epi-MAP

This paper introduces a human kidney epithelial microphysiological platform (Epi-MAP) to model collecting duct physiology from stem cells, enabling advanced functional analysis and drug testing.

Programmable 3D cell alignment of bioprinted tissue via soft robotic dynamic stimulation

This paper introduces a soft robotics-driven method to achieve programmable 3D cell alignment in bioprinted tissue through dynamic mechanical stimulation.

Bioprinting of aptamer-based programmable bioinks to modulate multiscale microvascular morphogenesis in 4D

This paper develops programmable bioinks using aptamers to control VEGF release and modulate microvascular network formation in 3D-bioprinted constructs, showing improved network properties with low-resolution designs.

Cytotoxicity and Characterization of 3D-Printable Resins Using a Low-Cost Printer for Muscle-based Biohybrid Devices

This study evaluates six 3D-printable resins for biohybrid muscle actuators, finding that Asiga DentaGUIDE and Formlabs Silicone 40A show minimal cytotoxicity and mechanical degradation.

Dynamic Kidney Organoid Microphysiological Analysis Platform

This paper introduces a dynamic kidney organoid microphysiological analysis platform to improve reproducibility, accuracy, and utility in kidney research and drug development.

Microplate micromilling: A customizable platform to support the prototyping, development and testing of microphysiological culture models

This paper introduces a microplate micromilling platform for rapid prototyping of microphysiological culture models and evaluates its performance against 3D printing.

Development of a Novel Method to Fabricate Highly Functional Human Purkinje Networks

This study develops a method to bioprint functional human Purkinje networks and compatible molds to study interactions with cardiomyocytes.

Digital Light Processing 3D Printing enables High Throughput Fabrication of Human Engineered Heart Tissues for Disease Modeling

This paper introduces a DLP-based 3D printing method for rapid, high-efficiency fabrication of human engineered heart tissues to model cardiac disease.

A microvascularized in vitro liver model for disease modeling and drug discovery

This paper develops a scalable in vitro liver model with microvascular components to study disease and drug responses, showing it can model steatosis and fibrosis.