Neuroscience of respiration and sleep

Sigh generation in preBötzinger Complex

The paper investigates neural mechanisms of sigh generation, showing that preBotC SST neurons can induce sighs independently of NMBR and GRPR pathways.

Inhibitory subpopulations in preBötzinger Complex play distinct roles in modulating inspiratory rhythm and pattern

The paper identifies distinct inhibitory subpopulations in the preBötzinger Complex and their specific roles in modulating inspiratory rhythm and pattern.

Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO2 chemoreflex in rats

This study shows that reducing PHOX2B in the retrotrapezoid nucleus of rats impairs CO2 chemoreflex during hypercapnia without affecting breathing in room air or hypoxia.

Chemo- and optogenetic activation of hypothalamic Foxb1-expressing neurons and their terminal endings in the rostral-dorsolateral PAG leads to tachypnea, bradycardia, and immobility.

The paper uses optogenetic and chemogenetic tools to activate Foxb1-expressing neurons in the hypothalamus and their terminals in the PAG, revealing their role in inducing tachypnea, bradycardia, and immobility.

Modeling effects of variable preBötzinger Complex network topology and cellular properties on opioid-induced respiratory depression and recovery

This study uses a computational model of the preBotC network to show that variability in network topology and neuronal properties influences opioid-induced respiratory depression and recovery.

Latent neural population dynamics underlying normal breathing, opioid induced respiratory depression, and gasping

The paper analyzes neural population dynamics in the Ventral Respiratory Column to understand breathing, opioid-induced respiratory depression, and gasping.

Apnoea suppresses brain activity in infants

This study examines how apnoea and breathing pauses affect brain activity in infants, finding reduced EEG amplitude during these events.

Neural correlate of reduced respiratory chemosensitivity during chronic epilepsy

This study investigates changes in respiratory chemosensitivity in mice with chronic epilepsy, finding reduced adaptive responses to hypercapnia and shifts in neuronal response patterns over time.

Chronic Intermittent Hypoxia reveals role of the Postinspiratory Complex in the mediation of normal swallow production

This study investigates how chronic intermittent hypoxia affects swallow behavior by examining the role of the Postinspiratory Complex in swallow-breathing coordination and motor patterning.

Interdependence of cellular and network properties in respiratory rhythmogenesis

The paper uses computational modeling to show that intrinsic bursting and pre-inspiratory spiking can be dissociated from the persistent sodium current in respiratory rhythm generation, supporting a unifying hypothesis involving both cellular and network properties.

Selective transduction and photoinhibition of pre-Botzinger neurons that project to the facial nucleus in rats affect the nasofacial activity

The paper demonstrates that selective photoinhibition of pre-Botzinger neurons projecting to the facial nucleus affects nasofacial activity, with anesthetic and consciousness state dependencies.

A change in behavioral state switches the pattern of motor output that underlies rhythmic head and orofacial movements

The paper shows that a behavioral state change alters the phase of motor output relative to sniffing during exploratory behavior in rats.

A tachykinin precursor 1 medullary circuit promoting rhythmic breathing

This study identifies Tac1-expressing preBotC neurons as excitatory cells that promote rhythmic breathing and locomotion in vivo.

Hif-2α programmes oxygen chemosensitivity in chromaffin cells

This study shows that HIF-2 activation induces oxygen chemosensitivity in adult adrenal medulla cells, similar to carotid body Type I cells.

Wireless monitoring of respiration with EEG reveals relationships between respiration, behaviour and brain activity in freely moving mice

This study develops a wireless respiration monitoring technique in mice and shows its relationship with behaviour and brain activity during exploration and different sleep states.

The role of Kölliker-Fuse nucleus in breathing variability

This study uses computational models to explore KF activity dynamics and their role in normal breathing and Rett syndrome-like respiratory patterns.

Opioid suppression of an excitatory pontomedullary respiratory circuit by convergent mechanisms.

This study identifies three convergent mechanisms by which opioids suppress an excitatory pontomedullary respiratory circuit, contributing to respiratory depression.

Postinspiratory complex acts as a gating mechanism regulating swallow-breathing coordination and other laryngeal behaviors

This study identifies the postinspiratory complex (PiCo) as a central gating mechanism that coordinates swallow and breathing behaviors through optogenetic experiments in mice.

Genetic identification of novel medullary neurons underlying congenital central hypoventilation syndrome

This study identifies dB2 neurons as causative of CCHS by showing their role in respiratory functions and neonatal survival using genetic and functional approaches.

A Consequence of Immature Breathing induces Persistent Changes in Hippocampal Synaptic Plasticity and Behavior: A Role of Pro-Oxidant State and NMDA Receptor Imbalance

This study shows that neonatal intermittent hypoxia causes a pro-oxidant state and NMDA receptor imbalance, leading to long-term synaptic plasticity and memory deficits, which can be mitigated by early antioxidant treatment.

A top-down slow breathing circuit that alleviates negative affect

The paper identifies a neural circuit involving dACC to PnC neurons that slows breathing and alleviates negative affect in mice.

Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window

This study shows that catenin signaling is essential for phrenic motor neuron development but not maintenance, affecting their topography, clustering, and axon/dendrite growth.

GASEOUS TRANSMITTER MODULATION OF HYPOGLOSSAL MOTONEURON ACTIVITY

The paper investigates how HO-2 and CSE-derived H2S modulate hypoglossal motoneuron activity in mice, showing their role in upper airway control during sleep apnea.

APOE4, Age & Sex Regulate Respiratory Plasticity Elicited By Acute Intermittent Hypercapnic-Hypoxia

This study identifies APOE4 genotype, sex, and age as factors influencing the respiratory plasticity response to acute intermittent hypercapnic-hypoxia in healthy adults.

Coordinated cadherin functions sculpt respiratory motor circuit connectivity

This study shows that coordinated cadherin activity in respiratory motor neurons and interneurons is essential for proper circuit connectivity and breathing function.

Recurrent hypoxia in a rat model of sleep apnea during pregnancy leads to microglia-dependent respiratory deficits and persistent neuroinflammation in adult male offspring

This study shows that maternal sleep apnea during pregnancy in rats leads to long-term respiratory deficits and neuroinflammation in male offspring due to microglia changes, while female offspring are unaffected.

Phox2b mutation mediated by Atoh1 expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia

This study shows that conditional Phox2b mutation in Atoh1-derived cells impairs respiratory rhythm and ventilatory responses to hypoxia and hypercapnia in mice.

Minimal models of the inspiratory and sigh breathing rhythms of the preBötzinger complex

The paper presents mathematical models of the inspiratory and sigh breathing rhythms in the preBötzinger complex, supporting a single-population rhythmogenic hypothesis.

Analyzing the neuroglial brainstem circuits for respiratory chemosensitivity in freely moving mice

The paper uses imaging to study neural activity in brainstem regions during CO2 exposure in mice, revealing distinct roles for RTN, Raphe, and pFL in respiratory chemosensitivity.

Microglia shape the embryonic development of mammalian respiratory networks

This study shows that microglia are essential for proper development of respiratory circuits in the mouse brainstem, as their absence leads to abnormal breathing rhythms and neonatal death.