Animal Virus Infections Studies

Fatal consequences of feline coronavirus infection are associated with virus persistence and a distinct adaptive immune repertoire

This study identifies immune repertoire changes and viral evolution in feline coronavirus infection, linking them to FIP severity and outcomes.

Rodents as Potential Reservoirs for Toroviruses

The paper identifies a novel torovirus in a dormouse, suggesting rodents may be a reservoir for toroviruses and highlighting their potential for cross-species transmission.

Convergent utilization of APN receptor by hedgehog merbecoviruses

The paper identifies hedgehog APN as a receptor for EriCoVs and shows convergent evolution in its utilization among merbecoviruses.

Adaptive mutations at lysine residues of PRRSV nsp12 enable evasion of host proteasomal and selective autophagic degradation

This study identifies adaptive mutations in PRRSV nsp12 that enable evasion of host proteasomal and autophagic degradation, enhancing viral replication and infectivity.

Field evaluation of non-invasive sampling for monitoring nine swine pathogens in the Republic of Korea

The paper evaluates non-invasive sampling methods for detecting swine pathogens in Korean farms, finding that oral fluid and fecal boot samples improve pathogen detection compared to standard methods.

High-Fidelity Long-Read Sequencing of an Avian Herpesvirus Reveals Extensive Intrapopulation Diversity in Tandem Repeat Regions

The paper uses long-read sequencing to analyze intrapopulation diversity in tandem repeat regions of Mareks disease virus strains, revealing phenotypic links to virulence and attenuation.

Integrating phylodynamics and historical records reveals decades-old introductions of PRRSV into Costa Rica via international swine trade

The paper uses phylodynamic analysis to trace the introduction of PRRSV-2 into Costa Rica through international swine trade, identifying at least two distinct introductions.

Nanopore direct-RNA sequencing reveals TGEV epitranscriptomic and transcriptomic landscapes modulated by gene 7

This study uses direct RNA sequencing to compare TGEV with and without gene 7, revealing changes in RNA modifications and polyA tails, and their impact on viral replication and host immunity.

Identification and characterization of novel bat coronaviruses in Spain

This study identifies six novel bat coronaviruses in Spain, three of which are potentially new species, and finds one can use human ACE2 receptor, indicating zoonotic potential.

Human cell adaptation of the swine acute diarrhea syndrome coronavirus spike protein

This study uses experimental evolution to identify mutations in the SADS-CoV spike protein that enhance its ability to infect human cells, potentially increasing its zoonotic potential.

Experimental inoculation of pigs with porcine respirovirus type 1 revealed pathological manifestations in the upper respiratory tract

This study inoculates pigs with porcine respirovirus type 1 (PRV1) and shows it causes chronic tracheitis and mild pneumonia in the upper respiratory tract, while swine orthopneumovirus (SOV) did not establish infection.

A functional interleukin-4 homolog is encoded in the genome of infectious laryngotracheitis virus: unveiling a novel virulence factor

This paper identifies a functional interleukin-4 homolog in the infectious laryngotracheitis virus genome, showing it enhances virulence and immune evasion.

229E- and NL63-like coronaviruses in phyllostomid bats, Belize

The paper identifies novel and previously known alphacoronaviruses in three bat species in Belize and finds phylogenetic similarity between bat CoVs and human 229E and NL63 coronaviruses.

Identification of within-host deletions in domain 0 of the spike gene of highly pathogenic feline coronavirus type 2 from the United States

The paper identifies a deletion in domain 0 of the spike gene in highly pathogenic feline coronavirus type 2 from U.S. cats, suggesting it as a biomarker for pathogenicity.

Detection of Feline Coronavirus RNA in Cats with Feline Infectious Peritonitis and their Housemates

This study compares FCoV RNA levels in FIP cats and their housemates across blood, conjunctiva, and feces, finding no difference between groups but higher levels in feces overall.

Construction of recombinant Bacillus subtilis spores surface-displaying PRRSV ORF1b, GP5, M, and N proteins in tandem and evaluation of their immunogenicity in mice

This study constructs a recombinant Bacillus subtilis spore displaying PRRSV proteins and evaluates its immunogenicity in mice, showing enhanced mucosal and systemic immune responses.

Navigating Neurological Re-emergence in Feline Infectious Peritonitis: Challenges and Insights from GS-441524 and Remdesivir Treatment

This paper describes a case of re-emerging feline infectious peritonitis (FIP) in a cat with neurological signs, highlighting the use of GS-441524 and remdesivir treatment and the role of AGP monitoring in detecting relapse.

Infectious Bronchitis: Molecular Detection and Characterization in Live Bird Markets in Jos, Plateau State, Nigeria

This study detects and characterizes infectious bronchitis virus in live bird markets in Nigeria, identifying two genotypes with notable relationships to known strains.

Genomics insights reveal multi-year maintenance of a new Deltacoronavirus infecting Seabirds from the Cagarras Island Archipelago Natural Monument, Brazil

The paper detects deltacoronaviruses in seabirds from Brazil, identifies full and draft genomes, and finds evidence of long-term viral maintenance through reinfection and immune escape mutations.

The role of innate immune responses against two strains of PEDV (S INDEL and non-S INDEL) in newborn and weaned piglets inoculated by combined orogastric and intranasal routes

This study compares innate immune responses in newborn and weaned piglets infected with two PEDV strains, finding that weaned piglets have stronger antiviral and pro-inflammatory responses despite similar viral replication.

Detection of Deltacoronavirus in Environmental Fecal Samples from Seabirds in the Saint Peter and Saint Paul Archipelago, central equatorial Atlantic Ocean

The paper detects deltacoronaviruses in environmental fecal samples from seabirds in the Saint Peter and Saint Paul Archipelago using RT-PCR and metatranscriptomics.

Detection and genetic characterization of pigeon gammacoronavirus

This study identifies and characterizes two nearly complete genomes of pigeon gammacoronaviruses, supporting their classification as a new species within the Igacovirus subgenus.

Pathogenesis and immune response to respiratory coronaviruses in their natural porcine host

This study compares immune responses and pathogenesis in pigs infected with two porcine respiratory coronavirus strains, finding that a more severe strain induces stronger inflammation and immune responses linked to pneumonia.

Sustained cross-species transmission of gammacoronavirus in wild birds reveled by viral characterization in China

The paper characterizes five new gammacoronavirus strains in wild birds, revealing cross-species transmission between marine mammals, poultry, and wild birds.

LPS/TLR4-Activating Exosomes from M1-Polarized Avian Macrophages Enhances IBV Vaccine-Induced Protective Immunity in Chickens

This study shows that exosomes from M1-polarized chicken macrophages enhance IBV vaccine immunity in chickens by boosting immune markers and reducing viral load.

An intra-family conserved high-order RNA structure within the M ORF is important for arterivirus subgenomic RNA accumulation and infectious virus production

Uncovering the Structural and Functional Implications of Uncharacterized NSPs and Variations in the Molecular Toolkit Across Mammalian and Non-Mammalian Arteriviruses

This study identifies uncharacterized NSPs and variations in molecular toolkits across mammalian and non-mammalian arteriviruses using comparative genomics and sequence-structure analysis.

First versatile reverse genetics system for feline coronavirus

This paper establishes a reverse genetics system for feline coronavirus to generate recombinant viruses for studying pathogenesis and antiviral responses.

Immunological response against bovine viral diarrhoea virus (BVDV) types 1 and 2 after vaccination with DIVENCE (R), measured by ELISA and serum neutralisation on serum and milk samples

This paper evaluates the immune response to the DIVENCE(R) vaccine against BVDV-1 and BVDV-2 using ELISA and serum neutralisation tests in serum and milk samples over time.

Global Distribution of Coronaviruses among Bat Populations detected using Molecular techniques, A Systematic Review

This study systematically reviews molecular studies on coronaviruses in bats, finding China has the most studies and PCR-based methods are widely used for detecting and sequencing bat coronaviruses.