Cytokine Signaling Pathways and Interactions

Janus Kinase 3 phosphorylation and the JAK/STAT pathway are positively modulated by follicle-stimulating hormone (FSH) in bovine granulosa cells.

The paper shows FSH activates JAK3 in bovine granulosa cells, increasing phosphorylation of STAT3 and other proteins, and modulating steroidogenesis and proliferation.

Signaling modality within gp130 receptor enhances tissue regeneration

This study identifies a gp130 signaling module that enhances tissue regeneration and prevents pathological outcomes by modulating cellular stress responses.

Regulation of distinct STAT3 dynamics in pro (IFNγ) and anti (IL-10) inflammatory pathways and in their cross-talk: insights from a data-driven model

The paper builds a data-driven model to analyze STAT3 dynamics in IFNγ and IL10 pathways and their cross-talk, identifying regulatory elements controlling their responses.

Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes define survival threshold in erythroid progenitor cells

The paper models single-cell variability in JAK2/STAT5 signaling and cytoplasmic volume to explain how erythroid progenitor cells transition from binary survival/apoptosis decisions to graded population responses upon Epo stimulation.

A novel small molecule LLL12B inhibits STAT3 signaling and sensitizes ovarian cancer cell to paclitaxel and cisplatin

This study develops a novel small molecule, LLL12B, which inhibits STAT3 signaling and enhances the efficacy of chemotherapy in ovarian cancer cells.

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disorders

The paper investigates how differential STAT binding to receptor phospho-Tyr motifs influences cytokine responses, showing altered dynamics in autoimmune disorders like SLE.

JAK1 palmitoylation by ZDHHC3/7 is Essential for Neuropoietic Cytokine Signaling and DRG Neuron Survival

Dynamic regulation of JAK-STAT signaling through the prolactin receptor predicted by computational modeling

The paper develops a computational model of JAK-STAT signaling through the prolactin receptor in beta cells, showing that receptor upregulation and regulatory modules are needed to match experimental STAT5 dynamics.

SOCS1/SOCS3 Immune Axis Modulates Synthetic Perturbations in IL6 Biological Circuit for Dynamical Cellular Response

The paper investigates the role of SOCS1/SOCS3 immune axis in modulating IL6 signaling during Leishmanial infection and proposes a synthetic biology approach to restore pro-inflammatory cytokine expression.

SILAC proteomics implicates the ubiquitin conjugating enzyme UBE2D in SOCS1-mediated downmodulation of the MET receptor in hepatocytes

The paper uses SILAC proteomics to show SOCS1 modulates 181 proteins in Hepa1-6 cells, with UBE2D being a key target involved in MET receptor regulation.

Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells

This paper identifies Y705 and S727 phosphorylation sites on STAT3 as critical for its mitochondrial import and transcriptional activity, which regulate stem cell proliferation in zebrafish and mouse models.

Muscle function and homeostasis require macrophage-derived cytokine inhibition of AKT activity in Drosophila

Characterization of Isoforms of the Ovine Granulocyte Colony Stimulating Factor

This study compares two ovine GCSF variants, finding that GCSFv2 has higher activity and mRNA expression than GCSFv1, and that the C-terminal region is most effective in promoting neutrophil maturation and progenitor cell functions.

Transcriptomic analysis of the BDNF-induced JAK/STAT pathway in neurons: a window into epilepsy-associated gene expression

The paper investigates the BDNF-induced JAK/STAT pathway in neurons, identifying its role in regulating ion channels, neurotransmitter receptors, and synaptic plasticity through non-canonical STAT3 activation.

Identification of an Essential IL15-STAT1-IRX3 Prosurvival Pathway in T Lymphocytes with Therapeutic Implications

The paper identifies an IL15-STAT1-IRX3 pathway that promotes T cell survival and reveals its therapeutic potential for immune malignancies, obesity, and autoimmune diseases.