Cytokine Signaling Pathways and Interactions

Structural basis for constitutive activation of oncogenic gp130 mutants in human inflammatory hepatocellular adenomas

This study identifies structural mechanisms of gp130 mutant activation in IHCAs using cryo-EM and mutagenesis, revealing two distinct dimer conformations and their activation dependencies.

Ligand Discrimination in Immune Cells: Signal Processing Insights into Immune Dysfunction in ER+ Breast Cancer

The paper measures ligand discrimination errors and molecular noise in immune cells of ER+ breast cancer patients compared to healthy controls using a communication model.

Exploring the functions of JAKMIP1 in neuronal IL-6/STAT3 signaling and its relevance to chromosome 15q-duplication syndrome

This study investigates JAKMIP1's role in neuronal IL-6/STAT3 signaling and its implications for Dup15q syndrome, finding that JAKMIP1 deficiency impairs signaling and neuritogenesis.

High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists

The paper designs novel cytokines by fusing computationally generated receptor-binding domains, identifying several that activate signaling pathways and have specific biological effects.

Geometric Tuning of Cytokine Receptor Association Modulates Synthetic Agonist Signaling

This paper designs synthetic cytokine agonists with controlled receptor geometry to modulate signaling outcomes and functional effects.

POZ Domain Transcription Factor Kaiso is a Downstream Effector of STAT1 for Multiple Myeloma Cell Survival and is also essential for Anoikis Resistance of Metastatic Solid Tumors

This study identifies Kaiso as a downstream effector of STAT1 in multiple myeloma cell survival and shows its role in anoikis resistance of metastatic solid tumors through repression of BMF.

Uncovering an unconventional JAK1/2-STAT3 branch in macrophage IFNγ signaling

The paper identifies an unconventional JAK1/2-STAT3 signaling pathway in macrophage IFNγ responses, showing STAT3 activation and heterodimerization with STAT1, but limited gene regulatory contribution.

Beyond Antagonism: IL-4 Exploits TNF signaling to Shape Its Gene Expression Signature in Monocytes and Macrophages.

The paper shows IL-4 enhances TNF-induced gene expression in monocytes/macrophages through epigenetic mechanisms, revealing cooperative crosstalk between antagonistic cytokines.

Glucose Metabolism Sustains Aberrant STAT3 Signaling in Colorectal Cancer via Glycosylated Paracrine Factors.

This study shows glucose metabolism sustains STAT3 activation in colorectal cancer through glycosylated paracrine factors, identifying a potential therapeutic target.

E-cadherin endocytosis promotes non-canonical EGFR:STAT signalling to induce cell death and inhibit heterochromatinisation

The paper shows E-cadherin endocytosis regulates EGFR:STAT signaling to induce apoptosis and inhibit heterochromatin formation in Drosophila wing discs.

Salmonella Effector SteE Reprogrammes the Macrophage Regulatory Network to Drive Specific Hyperactivation of STAT3 Target Genes

This study shows how Salmonella effector SteE reprograms macrophage gene regulation by hyperactivating STAT3, enhancing immune evasion.

A Goldilocks principle of JAK/STAT signaling governs airway epithelial homeostasis and stress adaptation in Drosophila

This study shows that JAK/STAT signaling in Drosophila airway epithelia must be balanced to maintain homeostasis and stress adaptation, with both insufficient and excessive activity causing pathology.

Lymphocytes and monocytes undergo swift suppression of IL-10R, IL-6R, and IL-2Rβγ signaling under high concentrations of different cytokines

The paper shows that lymphocytes and monocytes suppress IL-10R, IL-6R, and IL-2Rβγ signaling under high cytokine concentrations, mediated by cytokines that do not induce their own pSTATs.

Selective epigenetic regulation of IFN-γ signature genes by JAK inhibitor in inflammatory diseases

This study identifies JAK inhibitor-selective epigenetic regulation of IFN-γ signature genes in macrophages from RA and COVID-19 patients, revealing therapeutic insights and risks.

STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

The paper investigates two STAT5B mutations in T cell leukemias, showing one causes gain-of-function and the other loss-of-function, with distinct impacts on immune cell populations and transcriptional activity.

Identification of M-Sec as a unique cellular regulator of CSF-1 receptor activation

This study identifies M-Sec as a regulator of CSF-1 receptor activation by promoting Fms aggregate formation through PIP2 binding.

A CD25-CCR7 complex initiates non-canonical IL-2 signaling

This study identifies an IL-2 mutant that disrupts alternative signaling by blocking CD25-CCR7 complex formation while preserving canonical signaling.

STAT3 phosphorylation in the rheumatoid arthritis immunological synapse

This study identifies a JAK-independent mechanism of STAT3 activation in RA through TCR-dependent phosphorylation at the immunological synapse, suggesting a new therapeutic target.

Rbfox1 and mir-33 regulate pleiotropic roles of JAK/STAT signalling during adult myogenesis in Drosophila melanogaster

This study shows that Rbfox1 and mir-33 regulate Stat92E transcript stability and alternative splicing during Drosophila adult myogenesis, influencing JAK/STAT signaling outcomes.

Mutant TP53 switches therapeutic vulnerability during gastric cancer progression within Interleukin-6 family cytokines

This study identifies IL6/STAT3 signaling as a therapeutic target for TP53-mutant gastric cancer by showing its role in metastatic progression driven by mutant Trp53.

The Association between the JAK-STAT Pathway and Hypertension among Kenyan Women Diagnosed with Breast Cancer

This study investigates the association between JAK-STAT pathway gene expression and hypertension in Kenyan women with breast cancer, finding significant correlations between specific genes and blood pressure metrics.

STAT5B SH2 variants disrupt mammary enhancers and the stability of genetic programs during pregnancy

The paper investigates how two STAT5B SH2 domain variants affect mammary tissue development and lactation by altering enhancer recognition and gene regulation in mice.

A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory target gene expression

Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

The paper reports cryo-EM structures of fully assembled IL-12/IL-23 receptor complexes, revealing structural insights and differences in their interactions with receptors.

Predicting gene level sensitivity to JAK-STAT signaling perturbation using a mechanistic-to-machine learning framework

The paper predicts gene sensitivity to JAK-STAT perturbation by linking STAT phosphorylation dynamics to gene expression using a mechanistic-to-machine learning framework.

Characterization of an Osmr Conditional Knockout Mouse Model

The paper characterizes an Osmr conditional knockout mouse model, showing variable tissue-dependent effects on OSMR mRNA and protein expression.

STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia

This study shows that STAT3 and HIF1α work together to mediate hypoxia responses by physically interacting and enhancing HIF1α transcriptional activity.

Experiment-based Computational Model Predicts that IL-6 Trans-Signaling Plays a Dominant Role in IL-6 mediated signaling in Endothelial Cells

The paper develops a computational model to predict the role of IL-6 trans-signaling in endothelial cell signaling, showing it dominates over classic signaling in activating key pathways.

Tuning of cytokine signaling through imbalanced abundances of receptors and kinases

The paper investigates how receptor and kinase abundance imbalances affect cytokine signaling in T cells, finding that higher receptor levels can weaken signaling responses.

Mutual repression between JNK/AP-1 and JAK/STAT stratifies cell behaviors during tissue regeneration

The paper identifies a mutual repression network between JNK/AP-1 and JAK/STAT signaling that spatially segregates cell behaviors during tissue regeneration in Drosophila.