Neuroscience and Neural Engineering

Biologically plausible phosphene simulation forthe differentiable optimization of visual corticalprostheses

This paper presents a differentiable phosphene simulator for optimizing visual cortical prostheses using biologically plausible models of visual perception.

Shape-changing electrode array for minimally invasive large-scale intracranial brain activity mapping

This paper introduces a shape-changing electrode array for minimally invasive large-scale ECoG mapping, demonstrating its biocompatibility and high-resolution brain activity recording in rodents and canines.

High-Resolution Laminar Identification in Macaque Primary Visual Cortex Using Neuropixels Probes

This study develops high-resolution methods to identify thin layers in macaque V1 using Neuropixels probes by analyzing electrical signals and spike waveforms.

Cancer-mediated Axonal Guidance of Sensory Neurons in a Microelectrode-based Innervation MPS

This paper introduces a novel microelectrode-based 3D coculture system (INV-MPS) to study cancer-mediated axonal guidance and nociception in vitro, showing cancer spheroids can direct axonal growth and modulate neuronal excitability.

Kirigami electronics for long-term electrophysiological recording of human neural organoids and assembloids

This paper introduces kirigami electronics for long-term, minimally-invasive electrophysiological recording of human neural organoids and assembloids in suspension.

Targeted micro-fiber arrays for measuring and manipulating localized multi-scale neural dynamics over large, deep brain volumes during behavior

This paper introduces a micro-fiber array system for measuring and manipulating neural dynamics in large brain volumes during behavior, revealing spatiotemporal patterns of dopamine release and enabling precise optogenetic control.

Investigation of neural functional connectivity in thick acute mouse brain slices with novel multi-region 3D neural probe arrays

This study develops multi-region 3D neural probe arrays to record functional connectivity in thick acute mouse brain slices, showing improved single-unit signal detection compared to conventional slices.

Flexible, Scalable, High Channel Count Stereo-Electrode for Recording in the Human Brain

The paper introduces a high-channel-count flexible electrode for deep brain recording, capable of capturing single-unit activity from up to 128 channels.

ARViS: A bleed-free multi-site automated injection robot for accurate, fast, and dense delivery of virus to mouse and marmoset brains

ARViS enables precise, fast, and dense viral injection in mouse and marmoset brains with minimal bleeding, facilitating biosensor expression for imaging studies.

Multiformity of extracellular microelectrode recordings from Aδ neurons in the dorsal root ganglia: A computational modeling study

This study uses computational modeling to show how the geometry of Aδ neuron initial segments affects extracellular voltage waveforms recorded by microelectrodes in dorsal root ganglia.

Closed-loop control of functional electrical stimulation using a selectively recording and bidirectional nerve cuff interface

This paper demonstrates closed-loop control of functional electrical stimulation using a CNN to classify nerve cuff recordings and trigger stimulation based on detected hindpaw states.

Engineered Cortical Microcircuits for Investigations of Neuroplasticity

This paper presents a microfluidic platform for creating modular cortical neural networks to study neuroplasticity and network dynamics under perturbations.

Impact of microchannel width on axons for brain-on-chip applications

This study investigates how microchannel width and spatial constraints affect axon growth in brain-on-chip systems, finding that restrictions smaller than 350nm prevent axon penetration.

A microphysiological system for parallelized morphological and electrophysiological read-out of 3D neuronal cell culture

This paper introduces a microfluidic platform for 3D neuronal cultures with electrophysiological and morphological readouts, enabling high-throughput studies of neuronal networks.

Precise 3D Localization of Intracerebral Implants with a simple Brain Clearing Method

The paper introduces a method for precise 3D localization of intracerebral implants in rodent brains using tissue-clearing and light-sheet fluorescence microscopy, demonstrating its utility with implantation examples in transgenic mice.

Large scale, simultaneous, chronic neural recordings from multiple brain areas

The paper introduces a method for chronic, simultaneous neural recordings from multiple brain areas in mice, enabling long-term and flexible monitoring of neural activity during behavior.

Spatiotemporal recruitment of inhibition and excitation in the mammalian cortex during electrical stimulation

This study investigates how electrical stimulation affects inhibitory and excitatory neurons in the mammalian cortex, finding that increasing stimulation amplitude shifts the balance toward inhibition and correlates with behavioral changes.

Multi-day Neuron Tracking in High Density Electrophysiology Recordings using EMD

This paper introduces a neuron tracking method using non-rigid alignment of spike sorted clusters to identify the same neurons across multiple days in high density electrophysiology recordings, achieving an 84% average recovery rate.

In vivo multi-site electrophysiology enabled by flexible optrodes towards bi-directional spinal cord interrogation

This paper introduces a flexible optrode for multi-site optical stimulation and electrical recording in the spinal cord, demonstrating its potential for therapeutic applications.

Towards a more accurate quasi-static approximation of the electric potential for neurostimulation with kilohertz-frequency sources

This study evaluates the accuracy of quasi-static approximations for electric potential in neurostimulation models, showing when more precise calculations are needed for kilohertz-frequency signals.

Multi-region calcium imaging in freely behaving mice with ultra-compact head-mounted fluorescence microscopes

This paper introduces TINIscope, a compact head-mounted microscope for simultaneous calcium imaging in multiple brain regions of freely behaving mice, demonstrating its ability to record over 1000 neurons across four hippocampal subregions.

High-resolution neural recordings improve the accuracy of speech decoding

This study improves speech decoding accuracy using high-resolution ECoG recordings, achieving better phoneme decoding than standard methods.

Stimulation of Neurons and Astrocytes via Temporally Interfering Electric Fields

This study establishes an in vitro TIS setup using rat cortical neurons and astrocytes, showing that TIS elicits neuronal responses, which are reduced in co-cultures.

Multifunctional fibers enable modulation of cortical and deep brain activity during cognitive behavior in macaques

The paper demonstrates the use of multifunctional fibers to record and modulate neural activity in macaques during cognitive tasks, showing changes in neural activity with local inhibition.

Cellular Calcium Activity at Depth Predicted from Surface Potential Recordings using Ultra-high Density Transparent Graphene Arrays

The paper develops high-density transparent graphene electrodes to record neural activity from deeper cortical layers and decodes calcium activity from surface potentials using dimensionality reduction and neural networks.

Rolling 2D Bioelectronic film into 1D: a Suturable Long-term Implantable Soft Microfiber

The paper describes a method to roll 2D bioelectronic films into 1D microfibers for long-term implantable monitoring in rats, showing negligible fibroblast encapsulation after 13 months.

Pro-myelinating Clemastine administration improves recording performance of chronically implanted microelectrodes and nearby neuronal health

The paper shows that Clemastine treatment improves microelectrode recording performance and neuronal health by enhancing oligodendrocyte activity during chronic implantation.

Brain-machine interface learning is facilitated by specific patterning of distributed cortical feedback

This study shows that mice can learn to control a virtual cursor using a brain-machine interface only when artificial feedback is spatially and temporally contiguous across the somatosensory cortex.

Bypassing spike sorting: Density-based decoding using spike localization from dense multielectrode probes

This paper introduces a spike sorting-free decoding method using density-based modeling to improve neural decoding performance without explicitly clustering spikes.

Simultaneous Electrophysiology and Optogenetic Perturbation of the Same Neurons in Chronically Implanted Animals using microLED Silicon Probes

This paper describes a protocol for simultaneously perturbing and recording neural activity in chronically implanted rodents using LED silicon probes.