S100 Proteins and Annexins

Network of Interactions between the Tumor Necrosis Factor Superfamily Members and Small S100 Proteins

The paper identifies 27 interactions between 13 TNFSF members and 21 S100 proteins using surface plasmon resonance, showing calcium-dependent binding and conserved binding sites.

Annexin A6 modulates the secretion of pro-inflammatory cytokines and exosomes via interaction with SNAP23 in triple negative breast cancer cells

This study shows that Annexin A6 promotes secretion of pro-inflammatory cytokines and exosomes in TNBC cells through interaction with SNAP23.

Combined inhibition of S100A4 and TIGIT suppresses late-stage breast cancer metastasis to the lung by activating T and NK cells

This study shows that combining S100A4 and TIGIT inhibition suppresses breast cancer lung metastasis by enhancing T and NK cell activity in late-stage disease.

S100A8/A9 Inhibition Reduces Splenic Myelopoiesis and Improves Outcomes After Stroke

This study shows that S100A8/A9 inhibition reduces splenic myelopoiesis and improves stroke outcomes by decreasing neutrophilia and infarct size.

Teleost-specific ictacalcins exhibit similar structural organization, cation-dependent activation and transcriptional regulation as human S100 proteins

The paper characterizes two teleost-specific S100 proteins, S100i1 and S100i2, showing they share structural, functional, and expression features with mammalian S100 proteins.

Astrocytes modulate neuronal development by S100A6 signaling

This study identifies S100A6 as a signaling molecule released by astrocytes that modulates neuronal development by inhibiting CaCyBp-mediated signaling, affecting proteostasis and neuritogenesis.

Calcium-mediated amyloid co-aggregation of S100A1 and S100A8 proteins

This study investigates the calcium-dependent interactions and amyloid co-aggregation of S100A1 and S100A8 proteins, revealing their aggregation behavior is regulated by calcium ion concentrations.

Zebrafish do not have calprotectin

This study investigates whether zebrafish have calprotectin, finding no orthologs of mammalian S100A8 or S100A9 and no functional equivalents among zebrafish s100 proteins.

Calpains Orchestrate Secretion of Annexin-containing Microvesicles during Membrane Repair

The paper identifies calpains as key regulators of annexin-containing microvesicle secretion during plasma membrane repair, showing cleavage of annexins facilitates their release as MVs.

Versatile roles of Annexin A4 in ccRCC: impact on membrane repair, transcriptional signatures, and composition of the tumor microenvironment

This study identifies ANXA4 as a key player in ccRCC, showing its role in membrane repair, transcriptional changes, and tumor microenvironment composition through genetic and computational analyses.