Phagocytosis and Immune Regulation

Rituximab-IgG2 is a phagocytic enhancer in antibody-based immunotherapy of B-cell lymphoma by altering CD47 expression

This study shows RTX-IgG2 enhances phagocytosis of B-cell lymphoma cells by reducing CD47 expression and promoting apoptosis, improving the efficacy of antibody-based therapies.

CD47 predominates over CD24 as a macrophage immune checkpoint in cancer.

This study identifies CD47 as a more effective macrophage immune checkpoint than CD24 in cancer and develops bispecific antibodies to enhance macrophage-mediated tumor killing.

β-glucan reprograms macrophages to attenuate efferocytosis of cancer cells

This study shows that β-glucan induces trained innate immunity in macrophages, reducing their efferocytosis of cancer cells and altering inflammatory responses.

The ability of human TIM1 to bind phosphatidylethanolamine enhances viral uptake and efferocytosis compared to rhesus and mouse orthologs

This study compares the functional differences between human, rhesus, and mouse TIM1 proteins, showing that human TIM1's ability to bind phosphatidylethanolamine enhances viral uptake and efferocytosis compared to its orthologs.

Intestinal stem cells enhance local mucosal immunity through apoptotic body phagocytosis

This study shows that intestinal stem cells (ISCs) enhance local mucosal immunity by engulfing apoptotic bodies, which leads to increased T cell activity through TNF signaling.

Transcriptional analysis of efferocytosis in mouse skin wounds

This study examines how macrophages respond transcriptionally to efferocytosis in mouse skin wounds, finding both pro-repair and inflammatory responses depending on context.

Molecular tension authenticates apoptotic cells being phagocytosed

The paper identifies molecular tension between phosphatidylserine and its receptors as a signal determining phagocytosis of apoptotic cells.

P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by Borrelia burgdorferi

This study identifies P66, a bacterial protein mimicking CD47, which binds SIRPα to evade macrophage phagocytosis, and shows its role in Lyme Disease pathogenesis.

The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons

This study identifies Orion as a bridging molecule that connects phosphatidylserine and Draper in Drosophila phagocytosis of degenerating neurons, revealing a conserved mechanism.

Macrophages allocate independent of apoptosis and produce reactive oxygen species during interdigital phagocytosis

The paper shows macrophages prepattern interdigital regions for cell death independent of apoptosis and produce reactive oxygen species through lysosomal activity and oxidative burst.

The cationic amino acid exporter Slc7a7 is vital for and induced in tissue macrophages with sustained efferocytic activity

This study shows that Slc7a7 is essential for tissue macrophages with sustained efferocytic activity, as its expression is induced during efferocytosis and supports their survival.

Microglia in the developing retina couple phagocytosis with the progression of apoptosis via P2RY12 signaling

The paper investigates microglial phagocytosis of apoptotic cells in the developing zebrafish retina and shows that P2RY12 signaling is required for timely clearance.

RAB-35 aids apoptotic cell clearance by regulating cell corpse recognition and phagosome maturation

This study identifies RAB-35 as a gene critical for apoptotic cell clearance in C. elegans, showing its role in cell corpse recognition and phagosome maturation through interactions with TBC-10, FLCN-1, and RME-4.