Phagocytosis and Immune Regulation

Phosphatidylserine exposure by developing astrocytes initiates microglia-mediated developmental cell death

The paper shows that phosphatidylserine exposure by developing astrocytes triggers microglia-mediated cell death, leading to vascular defects in the retina and cerebral cortex.

Engineering SIRPα conformational plasticity to reveal a cryptic pocket suitable for structure-based drug design

This paper identifies a cryptic pocket in SIRPα that can be targeted for drug design by engineering conformational changes to expose it.

Target cell tension regulates macrophage trogocytosis

This study shows that target cell cortical tension determines whether macrophages trogocytose or phagocytose, with low tension favoring trogocytosis and high tension favoring phagocytosis.

Hyperactive Rac converts sublethal nibbling to lethal phagocytosis in vivo

This paper shows that hyperactive Rac in Drosophila border cells converts sublethal nibbling of nurse cells into lethal phagocytosis, revealing mechanisms that could inform cancer immunotherapy.

Enhancement of activation-induced T cell proliferation by SIRPG in a CD47-independent manner

This study shows SIRPG enhances T cell proliferation and CRTAM expression in a CD47-independent manner through its cytoplasmic domain.

Phospholipid Scramblases TMEM16F and Xkr8 regulate distinct features of Phosphatidylserine (PS) externalization and immune regulation in the tumor microenvironment to regulate tumor growth

This study shows that Xkr8 and TMEM16F regulate distinct PS externalization mechanisms in the tumor microenvironment, influencing immune evasion and tumor growth.

Beta-2-microglobulin stimulates neutrophil phagocytosis of bacteria and apoptotic cells

This study shows that beta-2-microglobulin enhances neutrophil phagocytosis of bacteria and apoptotic cells, contributing to innate immunity and tissue homeostasis.

Sympathetic signaling directs macrophage efferocytosis in thermogenic adipose tissue

The paper identifies norepinephrine as a trigger of macrophage efferocytosis in brown adipose tissue, linking sympathetic signaling to metabolic adaptation through β2-adrenergic and Axl/Mertk pathways.

Macrophage efferocytosis is controlled by epigenetic modifications mediated by RBPJ

This study identifies RBPJ-mediated epigenetic regulation of efferocytosis in macrophages, showing that suppression of H3K9me3 enhances apoptotic cell clearance and suppresses inflammation.

Macrophage WDFY3, a protector against autoimmunity

This study shows WDFY3 protects against autoimmunity by enhancing macrophage efferocytosis, reducing autoantigen release, and suppressing T cell and inflammasome activation.

CD47 promotes MAPK and epithelial-to-mesenchymal transition molecular programs to drive pro-metastatic phenotypes in non-small cell lung cancer

This study identifies CD47's role in promoting MAPK and EMT pathways to drive metastasis in NSCLC through cell-intrinsic signaling, independent of immune evasion.

Metabolic and transcriptional adaptations to phagocytosis in microglia sustain their functionality and regenerative properties

The paper investigates metabolic and transcriptional changes in microglia after phagocytosis, showing these adaptations sustain their functionality and regenerative properties.

CD47 prevents Rac-mediated phagocytosis through Vav1 dephosphorylation

This study shows CD47 inhibits Rac-mediated phagocytosis by preventing Vav1 phosphorylation, shifting the mechanism from Rac-based reaching to Rho-based sinking.

Binding of inhibitory checkpoints to CD18 in cis hinders anti-cancer immune responses

The paper shows inhibitory checkpoints like SIRP and PD-1 hinder anti-cancer immune responses by cis-interacting with CD18, in addition to their trans interactions with tumor cell ligands.

Differential Phagocytosis induces Diverse Macrophage Activation States in Malignant Gliomas

This study investigates how differential phagocytosis induced by RT or anti-CD47 therapy affects macrophage activation states in gliomas, showing that combination therapy reduces tumor growth and induces distinct macrophage states.

Target cell adhesion limits macrophage phagocytosis and promotes trogocytosis

This study shows that target cell adhesion limits macrophage phagocytosis and promotes trogocytosis, with reduced adhesion increasing phagocytosis.

Myeloid cell-mediated killing of B-ALL by CD38 and CD20IgA antibody variants is enhanced by CD47/SIRPα interference

This study evaluates the efficacy of CD38 and CD20 IgG1/IgA2 antibodies in mediating myeloid cell-mediated killing of B-ALL, showing enhanced activity with CD47/SIRPα blockade.

Inhibition of AXL dependent non-professional efferocytosis sensitizes pancreatic cancer to immune checkpoint blockade

This study shows that inhibiting AXL in pancreatic cancer cells enhances immune checkpoint therapy by blocking non-professional efferocytosis and increasing CD8 T cell infiltration.

Phosphatidylethanolamine is a phagocytic ligand implicated in the binding and removal of apoptotic and microbial extracellular vesicles

This study identifies phosphatidylethanolamine (PE) as a phagocytic ligand recognized by CD300 receptors, facilitating the uptake of apoptotic cells and microbial extracellular vesicles.

Engulfing to Adapt: Efferocytosis by Epithelial Cells Triggers Cell State Transitions During Tissue Remodeling

The paper shows that efferocytosis by epithelial cells during hormone deprivation in prostate cancer triggers metabolic and gene expression changes that reprogram cells for regeneration.

The secreted Nimrod NimB1 negatively regulates early steps of apoptotic cell phagocytosis in Drosophila

This study identifies NimB1 as a secreted protein that inhibits early apoptotic cell phagocytosis in Drosophila by binding phosphatidylserine on apoptotic cells, opposing the function of NimB4.

Transglutaminase 2 function in glioblastoma tumor efferocytosis

This study shows TGM2 is involved in efferocytosis by glioblastoma-associated macrophages, promoting immunosuppression and tumor survival.

CD47 blockade enhances immunoradiotherapy response in head and neck squamous cell carcinoma

This study shows CD47 blockade combined with anti-PD1 and radiotherapy improves tumor response in HNSCC by enhancing antigen presentation and immune cell infiltration.

Sialylated CD43 is a glyco-immune checkpoint for macrophage phagocytosis

The paper identifies CD43 as a glyco-immune checkpoint that inhibits human macrophage phagocytosis, showing that O-linked glycosylation and sialylation pathways regulate this process in AML.

Isoform switch of CD47 provokes macrophage-mediated pyroptosis in ovarian cancer

This study shows that switching CD47 isoforms from full-length to truncated in ovarian cancer cells triggers macrophage-mediated pyroptosis and reduces tumor growth.

Bifunctional Phagocytic Synapse Enhancers for Cancer Immunotherapy

This paper introduces PSEs, bifunctional molecules that enhance phagocytosis and block PD-L1, showing improved antitumor responses in animal models.

Multi-scale simulations of membrane adhesion mediated by CD47-SIRPα complexes

This study uses multi-scale simulations to model CD47-SIRPα-mediated membrane adhesion, reproducing experimental data and predicting conformational changes and cooperativity.

GEI-17-Mediated SUMOylation of GDI-1 Regulates Apoptotic Cell Clearance

This study identifies GEI-17-mediated SUMOylation of GDI-1 as a mechanism regulating phagosomal degradation and apoptotic cell clearance in C. elegans and mammals.

SMAC mimetics induce human macrophages to phagocytose live cancer cells

This study shows SMAC mimetics, when combined with IFN{psi}, enable human macrophages to phagocytose live cancer cells across multiple donors.

Estrogens increase cancer cell efferocytosis to establish an immunosuppressive tumor microenvironment

This study shows that estrogens enhance tumor-associated macrophage efferocytosis, promoting immunosuppression, and demonstrates that targeting the E2/ER/CX3CR1 axis can reverse this effect and improve radiation therapy.