Discover, rate, and verify biology preprints.

Coacervate droplet sequestration of heterogenous nanoplastics with elastin-like polypeptides

This study uses coacervate droplets with elastin-like polypeptides to selectively capture incidental nanoplastics, showing over 80% capture efficiency for nPET.

Distinct Roles of Surface Nanostructure and Polymer Degradation in Fibroblast Response to Device Design

This study examines how porous device design influences fibroblast activation into myofibroblasts, showing that polymer degradation and nanoparticle surface features significantly impact fibrotic responses.

Raybloc: A Marine Bioactive Silica-Microsponge Formulation Confers Superior Protection against Blue Light and Infrared-A Induced Skin Damage in Murine Model

Raybloc, a marine silica microsponge, reduces TEWL and oxidative stress in mice exposed to blue light and infrared-A radiation.

Computational aberration-corrected volumetric imaging of single retinal cells in the living eye

This paper introduces PI-SLO, a 3D imaging technique for volumetric single-cell imaging in living mouse retinas, enabling studies of microglial dynamics, vascular perfusion, and calcium fluxes.

Apollo-IRE1: A Genetically Encoded Sensor for Live Cell and Multiplexed Imaging of ER Stress

Apollo-IRE1 is a genetically encoded sensor that detects ER stress by measuring IRE1 oligomerization and fluorescence anisotropy changes, enabling multiplexed imaging in living cells.

Pro-domain-dependent folding and co-receptor-mediated targeting to optimize an antagonistic TGF-β monomer for gene-based delivery

This paper improves the folding and targeting of an engineered TGF-β monomer for gene-based delivery by modifying its pro-domain and adding a CD44 binding domain.

Programmable domestication of thermophilic bacteria through removal of non-canonical defense systems

This paper develops a method to make thermophilic bacteria genetically tractable by removing non-canonical defense systems, enabling stable genetic modification at high temperatures.

Collagen-based bilayered biomimetic tubular materials for vascular and airway applications

This paper presents collagen-based bilayered tubular scaffolds for vascular and airway applications, demonstrating compliance and flexibility suitable for implants but with limitations in suture retention strength.

Sentinel Plants Enable Aboveground Detection of Belowground Soil Microbial Activity

This study develops engineered sentinel plants that detect belowground microbial activity through an aboveground signal, enabling noninvasive monitoring of soil microbial processes.

Physiological perfusion of human vasculature reveals a YAP/TAZ-Apelin switch linking intraluminal flow to endothelial state transitions and vessel remodeling

The paper introduces VIVOS, a 3D human vascular platform that links intraluminal flow to endothelial state transitions and vessel remodeling through YAP/TAZ-Apelin signaling.

Effects of Unexpected Underfoot Perturbations During Turning on Measures of Mediolateral Stability and Corresponding Recovery Strategies

This study examines how unexpected underfoot perturbations during turning affect mediolateral stability and recovery strategies in humans.

A graph-based deep learning framework for diabetic retinopathy classification with topology-aware feature augmentation

This paper introduces a graph-based deep learning framework for diabetic retinopathy classification that incorporates topological features and relational graph learning, achieving higher accuracy than standard CNNs.

In-Situ ssDNA Isolation from dsDNA Sources as a Streamlined Pathway to DNA Origami Assembly and Testing

This paper introduces a method to isolate ssDNA from dsDNA sources for DNA origami assembly, demonstrating its effectiveness across various dsDNA types and lengths.

Glycoengineering of extracellular vesicles enhances cellular uptake and cargo delivery to target cells

This study shows that removing glycosaminoglycans from extracellular vesicles increases their uptake and cargo delivery to target cells, suggesting glycan structures can be tuned for better drug delivery.

Computational modeling of left ventricular flow using PC-CMR-derived four-dimensional wall motion

This study integrates MRI modalities with computational fluid dynamics to model left ventricular flow, improving clinical assessment of cardiac hemodynamics without complex myocardial modeling.

A New Mathematical Model for LVAD-Supported Ventricles: Direct Parameterization from Ramp-Test Clinical Data and Verification via Hybrid Modeling

This paper develops a patient-specific mathematical model of LVAD-supported ventricles using clinical ramp-test data and validates it through hybrid modeling to assess intrinsic LV function.

Multi-objective optimization-based design of a compliant gravity balancing orthosis: development and validation

This paper develops a multi-objective optimization framework for designing a compliant gravity balancing shoulder orthosis, validated through mechanical testing and in-vivo muscle activity reduction in healthy individuals.

Bacterial Spores as a Scalable, Modular Platform forthe Production of Amyloids for Materials

This paper demonstrates a platform using engineered Bacillus subtilis spores to display amyloids for materials, achieving high yields and modified mechanical properties.

In Vivo Metabolic Tagging and Targeting of Circulating Red Blood Cells

This paper develops an in vivo method to label and target red blood cells with azido groups, enabling long-term cargo delivery and improved imaging.

Sensitive Hormone and Neurotransmitter Detection with Carbon Flower Electrodes

This paper develops carbon flower sensors for sensitive and selective detection of hormones and neurotransmitters in complex biofluids.