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A Modular Synthetic Hydrogel with Cell-scale Micropores Modulates Osteocyte-like Morphogenesis and Osteogenic Differentiation In Vitro

This study investigates how cell-scale micropores in synthetic hydrogels affect osteocyte-like morphogenesis and osteogenic differentiation in vitro.

The Effect of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) on Cardiorespiratory Physiology: Four Waveforms Trial with Tragus vs Earlobe Stimulation

This study evaluates the acute effects of four taVNS configurations on cardiorespiratory physiology, finding that unilateral left 25 Hz tragus stimulation increases heart rate variability compared to earlobe control.

De novo design of small-molecule-induced conformational change

This paper designs de novo proteins that undergo small-molecule-induced conformational changes, demonstrating strong binding affinity and specificity for exatecan.

Seed-Guided De Novo Design Expands the Structural Diversity of Antitoxin Protein Binders

This paper introduces seed-guided diffusion-based design to improve structural diversity and target contact in antitoxin protein binders, achieving functional binders with enhanced selectivity.

Performance of a Modular Robotic Cluster Matches Skilled Human Operators for Complex Cell Therapy Manufacturing Tasks

A modular robotic system performs key unit operations in cell therapy manufacturing with accuracy comparable to human operators while ensuring throughput and flexibility.

Classifier-guided Deep Oscillatory Neural Networks (cDONN) for capturing both Neural Dynamics and Behavior simultaneously

This paper introduces cDONN, a neural network that generates EEG signals and classifies behavior simultaneously, showing high fidelity in synthesized EEG data.

Depth-Dependent Advantages of Three-Photon Microscopy for Imaging Through Intact Murine Cortical Bone and Into the Marrow

This study compares two-photon and three-photon microscopy in ex vivo mouse bones, finding 3P provides better image quality beyond 50 micrometers and enables visualization of marrow cells through intact bone.

Mechanically Compliant, Precision-Porous Brain Implants Reduce the Foreign Body Reaction and Guide Regeneration

Brain-stiffness-matched pHEMA/GMA hydrogel scaffolds with 40 µm interconnected pores reduced astrocyte encapsulation and iNOS+ macrophage fraction versus stiff solid rods after 4 weeks in rat brain.

Long-term Production and Recovery of Medium-Chain Carboxylates from Source-Separated Organics

This study demonstrates long-term production and recovery of medium-chain carboxylic acids from source-separated organics using microbial chain elongation and in-line extraction.

High-channel-count neural recording and stimulation platform with 5,376 simultaneous recording channels

This paper introduces a high-channel-count neural recording and stimulation platform with 5,376 channels, demonstrating its use in high-resolution cortical mapping in rat brains.

Extracellular Vesicle Carryover Distorts Nanoparticle Protein Corona Profiles in Human Plasma

This paper shows that extracellular vesicles contaminate nanoparticle protein corona profiles in human plasma, leading to inaccurate protein origin assignments.

Synergy-based Feedforward with Minimal Feedback Control Predicts Walking Over Multiple Cycles

This study develops a synergy-based feedforward plus feedback control model for post-stroke walking, finding that 100% feedforward control best reproduces experimental data.

Degradable porous PLGA/PCL membrane enable a lung alveoli-on-a-chip for modeling particulate-induced alveolar injury

This paper develops a degradable PLGA/PCL membrane for a lung alveoli-on-a-chip system to model particulate-induced alveolar injury and assess therapeutic responses.

Tomographic Printing in a Chip: A Versatile Platform for Biomimetic 3D Organ-on-Chip

This paper introduces a new 3D organ-on-chip platform using tomographic volumetric additive manufacturing integrated into microfluidic chips, enabling rapid and reproducible fabrication of complex biological models.

Pilot-scale production of leucine from CO2

This paper reports the first archaeal cell factory for leucine production from CO2, achieving high productivity and economic feasibility in a pilot-scale bioprocess.

Mapping the thymus in the viscoelastic landscape of biological tissues

This paper characterizes the viscoelastic properties and 3D architecture of bovine thymus extracellular matrix, providing a dataset for tissue engineering applications.

Biodegradable Architected Stents for Endoscopic Internal Drainage

The paper introduces a biodegradable stent with an architected lattice design that improves flexibility, kink resistance, and drainage while eliminating the need for removal.

CALIPERS: Cell cycle-aware live imaging for phenotyping experiments and regeneration studies

CALIPERS enables cell cycle-aware live imaging by integrating a modified FUCCI variant, analysis software, and reporter lines for phenotyping and regeneration studies.

Computational fluid dynamics enables predictable scale-up of perfusion bioreactors for microvessel production

This paper uses computational fluid dynamics to guide the scaling of perfusion bioreactors, showing that maintaining interstitial flow ensures reproducible microvessel networks across 30-fold volume increases.

Machine learning surrogate forward models for biomechanical laryngeal control

This paper uses machine learning models to create fast surrogates for biomechanical laryngeal control models, enabling real-time applications with reduced computational costs.