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Multiscale Biomechanical and Electrophysiological Modeling of Nociceptive Activation in Musculoskeletal Joint Disorders: Insights from the Temporomandibular Joint

This study develops a multiscale computational model linking TMJ structural changes to nociceptive activation by integrating biomechanics, neural morphology, and electrophysiology.

Post-loading ribonucleic acid into lipid nanoparticle carriers

This paper introduces a post-loading method for mRNA into lipid nanoparticles to reduce cold storage requirements, achieving comparable delivery efficiency to conventional methods.

Threshold-Free Neural Network Models for Swim Bout Detection of Larval Zebrafish

This paper develops threshold-free deep learning models for detecting swim bouts in larval zebrafish, showing improved precision over traditional methods and revealing behavioral patterns across genetic backgrounds.

Randomized Spatial Barcoding for Time-Lapse Flow Cytometry

The paper introduces RASPBerry, a hydrogel-based spatial barcoding platform for time-lapse flow cytometry, enabling tracking of suspended cells with high accuracy and throughput.

Tunable Laminar Perfusion Coordinates Endothelial and Perivascular Remodeling in Angiogenic Vasculature-on-Chip

This study introduces a tunable laminar perfusion system for vasculature-on-chip to study sustained flow effects on vascular remodeling and immune interactions.

Multilevel engineering of cyanobacterial energy metabolism advances photosynthetic hydrogen production while revealing its constraints

This study enhances cyanobacterial photosynthetic hydrogen production by addressing multiple metabolic constraints, achieving higher yields but also revealing trade-offs with metabolic stability.

Thermodynamic continuum tumour modelling recovers multicompartment spheroid structure and supports drug-response screening

This paper develops a thermodynamic continuum model of tumour spheroid growth that recovers multicompartment structure and supports drug-response screening without prescribing compartments.

Microbial Influenced Corrosion: A Novel Initiator of In Vivo Spine Rod Fracture

The paper investigates the role of microbial influenced corrosion (MIC) in causing spine rod fractures by analyzing tissue samples from patients with titanium implants.

Critical Process Steps for Mechanical Agitation Driven Coated Nanobubble Self Assembly

This paper identifies critical process parameters for producing stable, uniform coated nanobubbles via mechanical agitation.

Resolving heterogeneity of targeted lipid nanoparticles through solution-based biophysical analyses

This study resolves heterogeneity in targeted lipid nanoparticles (tLNPs) using biophysical methods, showing that subpopulation structure, not bulk properties, determines targeted RNA delivery.

Supramolecular hydrogel viscoelasticity regulates in situ tertiary lymphoid neogenesis

This study shows that soft hydrogels promote tertiary lymphoid structure formation, while stiff hydrogels hinder it, improving antitumor immunity.

A high-throughput, 3D microtissue platform for multiparametric analysis of tissue remodeling.

This paper introduces a high-throughput 3D microtissue platform for analyzing tissue remodeling dynamics, showing it better aligns with clinical outcomes than 2D assays.

Combination siRNA delivery as a therapeutic strategy for ADPKD

This study demonstrates that dual-target siRNA delivery using CD-targeting micelles reduces cyst growth in ADPKD models by silencing TMEM16A and MCP-1.

Ocular Safety and Efficacy of AAV-mediated Tyrosinase Gene Augmentation in a Nonhuman Primate Model

This study evaluates the safety and efficacy of AAV-mediated TYR gene augmentation in nonhuman primates for OCA1 treatment, showing localized hypermelanosis and RPE transduction without severe adverse effects.

Using large language models for enhancing accessibility for Monte Carlo photon transport simulations and beyond

This paper develops an LLM interface for scientific simulations, achieving high accuracy and reproducibility in converting natural language descriptions to structured inputs for photon transport simulations.

Physiological Cross-Sectional Surfaces: A Method for Estimating Muscle Functional Capacity from 3D Digital Models of Fiber Architecture

This paper introduces PCSS, a 3D method to estimate muscle functional capacity from MRI data, showing it outperforms conventional 2D measures in complex muscle geometries.

Experimentally Tuned Protein-RNA Rosetta Score Function using Bayesian Optimization

The paper develops an experimentally tuned protein-RNA score function for ROSETTA using Bayesian Optimization to improve energetic agreement with experimental data.

Instantaneous Phase-Shifting Optothermal Microscopy for Live-cell Metabolic Monitoring

This paper introduces IPSOM, a fast optothermal microscopy method for live-cell metabolic monitoring, demonstrating its application in tracking lipid remodeling in adipocytes.

Multi-Modal photoFRESH: Light-Pipe Embedded Printing of Heterogeneous Hydrogel and Tissue Architectures

The paper introduces multi-modal photoFRESH, a 3D bioprinting technique that enables precise control of crosslinking, stiffness, and biomolecular tethering through localized photochemistry, resulting in structurally complex and heterogeneous tissue constructs.

Texture Profile Analysis and Consumer Sensory Evaluation of Plant-Based and Conventional Breaded Shrimp

This study compares the textural properties and consumer acceptance of plant-based and conventional breaded shrimp, finding that plant-based shrimp are harder and chewier but receive comparable hedonic ratings.