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This study uses cryo-EM to visualize E. coli RNAP collisions with roadblocks and other RNAPs, revealing structural changes and mechanisms of collision resolution.

This paper presents cryo-EM structures of CCR7 with CCL19 and CCL21, revealing distinct binding modes and dynamic receptor conformations that underlie biased agonism and differential signaling outcomes.

The paper shows that fibrillar adhesions control nuclear mechanical response timescales through vimentin cytoskeleton anchoring via plectin 1f.

The paper develops an agent-based model to simulate axonal growth during zebrafish spinal cord regeneration and shows it aligns with experimental imaging data.

This study investigates the microscopic dynamics of cells in high-density epithelial tissues, revealing sub-diffusive creep and stress-driven fluidity despite their jammed state.

This study uses fluorescent noncanonical amino acids to measure conformational changes in hHv1, showing Zn2+ induces reversible FRET changes.

This study experimentally demonstrates intracellular heat retention mediated by membrane dynamics, showing heat generated by metabolism is partially retained and used for efficient energy flow.

This study shows that charged agar surfaces alter E. coli biofilm properties by influencing curli amyloid quantity and quality, affecting structure and stability.

This study shows that hnRNPA1 phase separation is suppressed at high RNA concentration due to competition with protein-RNA cluster formation, with specific RNAs promoting clusters more effectively than unspecific ones.

This study quantifies telomere dynamics in HGPS patient fibroblasts and shows that C75 fully restores chromatin dynamics while Lonafarnib only partially rescues them.

This study identifies an oncogenic TMD mutation in IL-7R that causes ligand-independent signaling and shows that rationally designed transmembrane helices can reverse this effect.

This study shows ceramides disrupt VDAC-HKI complex assembly by modulating VDAC tilt and membrane thinning, revealing a mechanism for ceramide-induced apoptosis.

This study shows clathrin accessory proteins destabilize protein condensates while promoting clathrin lattice assembly and exclusion, revealing a mechanism linking phase separation to endocytosis.

This study investigates how TFAM organizes mtDNA into compact higher order structures through biochemical and structural analysis of TFAM oligomerization on longer DNA.

This paper introduces a high-throughput droplet microfluidics method to quantify individual phage infection events, offering a more accurate understanding of phage-host dynamics.

The paper uses a deep sequencing assay to analyze how mutations affect circadian clock phenotypes, revealing factorized oscillator properties and mutation-specific effects on period and amplitude.

This study uses metal-induced energy transfer to reveal that cytokine receptor intracellular domains compact upon activation.

This paper introduces a framework for prebiotic selection as a physical process, showing it can explain chemical convergence in amino acids and nucleobases across diverse environments.

This study shows that M protein interactions alone can drive clustering in ERGIC-like lipid bilayers, with direct interactions being stronger than membrane-mediated ones.

This paper introduces AFLF, a method to generate diverse protein conformations from sequence using AlphaFold's latent space, showing it captures structural fluctuations and binding sites.