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Characterizing risky play-like behaviour in juvenile versus young adult rats

This study identifies and quantifies risky play-like behaviour in juvenile and young adult rats using ethological frameworks to assess developmental changes in engagement with elevated and unstable environments.

A portable C-terminal rheostat calibrates RecE/Redα exonuclease activity for enhanced bacterial recombineering

The paper identifies a highly active RecET recombinase pair for efficient homologous recombination in Streptomyces, enabling large DNA integration with minimal homology arms.

Distinct gradients of cortical architecture capture visual representations and behavior across the lifespan

The paper shows two architectural gradients in human visual cortex that correlate with structural, functional, and behavioral traits across the lifespan.

A synthetic genetic switch for tracking T-DNA delivery supports integration-free genome editing in plants

The paper develops T-SWITCH, a synthetic genetic switch that tracks T-DNA delivery and integration in plants, enabling integration-free genome editing.

Injectable Nanoparticles Assemble In Situ into Modular, Functionally Segmented Brain Electrodes

The paper develops injectable nanoparticles that form soft, functionally segmented brain electrodes capable of neuronal stimulation and gene transfer in chicken embryos.

The Effects of Physical Exercise on Osteocyte Lacunar Morphology and Orientation around Bioresorbable Implants

This study examines how physical exercise affects osteocyte lacunar morphology and orientation around bioresorbable implants in rats, showing increased lacunar size and altered orientation with exercise.

Electrically Enhanced Intraperitoneal Drug Delivery Resolved by Fluorescence Lifetime Imaging Microscopy

This study evaluates electrically enhanced intraperitoneal drug delivery using nanoparticles and fluorescence lifetime imaging microscopy to track drug penetration and intracellular release.

Towards a complete diploid chicken genome

This paper presents a nearly complete haplotype-resolved chicken genome using trio-sequencing and long-read data, identifying gaps and structural variants in dot chromosomes.

An endothelial-specific TIE2-L914F mouse model reveals cellular mechanisms of venous malformation progression and recapitulates the patient's response to targeted therapy

This study creates a TIE2-L914F mouse model to study venous malformation progression and shows it responds to rapamycin treatment.

Yeast PI(3,4,5)P3 controls vacuole fusion through Vam7 and membrane microdomain assembly

This study identifies PI(3,4,5)P3 as a regulator of yeast vacuole fusion, showing it controls vertex microdomain assembly and retains the SNARE Vam7 on membranes.

Breaking new ground into RAD51-BRC repeats interplay in Homologous Recombination

This study investigates the RAD51-BRC repeats interaction using computational and experimental methods to better understand its role in homologous recombination and its implications for cancer.

PDGFD-induced pericyte contractility drives pathological neoangiogenesis

This study identifies PDGFD-ROCK-NMIIA signaling in pericytes as a driver of pathological neoangiogenesis in retinopathies, revealing cell-type-specific actomyosin contractility mechanisms.

Epigenetic Remodeling Increases Plasticity of Bovine Fibroblasts Without Improving Embryo and Stem Cell Development

This study evaluates a multi-target small-molecule cocktail, GUSTC, to reduce repressive heterochromatin marks in bovine fibroblasts, enhancing reprogramming potential without improving embryo development.

A droplet-to-data workflow for antimicrobial screening of complex matrices

The paper presents a droplet-based workflow for antimicrobial screening in complex matrices, showing it can detect MICs at lower concentrations and reveal extract-specific aggregation effects.

Brain and kidney Extracellular Vesicle Morphology and Complementary Brain proteomics after Inflammatory Challenge

The paper compares brain and kidney extracellular vesicle morphology and proteomics after inflammatory challenge, identifying significant protein changes but noting limitations in causal conclusions.

Achilles Heel: Type VII Toxin/Antitoxin System Hha/TomB Facilitates Phage Infection by Regulating Cryptic Prophage Lytic Genes

The paper shows that the Hha/TomB type VII TA system in E. coli promotes phage infection by activating cryptic prophage lytic genes, contrary to the typical phage inhibition role of TAs.

Experimental evolution unveils a role for structural variants and sex-specificity in the genetic architecture of lifespan

This study uses experimental evolution in seed beetles to show that structural variants and sex-specific genetic factors influence lifespan evolution.

End-To-End, Fully Automated Manufacturing of Hematopoietic Stem and Progenitor Cell Therapy Via CCR5-Targeted Integration

This paper demonstrates an automated, high-throughput platform for manufacturing gene-edited hematopoietic stem and progenitor cells (geHSPCs) with preserved function and in vivo engraftment capacity.

A chromosome-level genome assembly of the classical model nematode Panagrellus redivivus for comparative studies of parasitism evolution

The paper presents a chromosome-level genome assembly of Panagrellus redivivus, enabling comparative studies of parasitism evolution by providing a non-parasitic reference genome.

Oxidized EGCG redirects α-synuclein aggregation through shear-selected interactions

This study shows that oxidized EGCG, not unoxidized EGCG, binds α-synuclein, inhibits fibrillation, and remodels fibrils, with shear flow affecting these interactions.