B. Li

This study uses single-cell RNA-seq and TCR sequencing to analyze CMV-reactivated CD4+ T cell subsets, revealing their heterogeneity, functional roles, and interactions.

The paper identifies C53 as a conserved ER-phagy receptor that links autophagy with ribosome-associated quality control during ER stress in plants and mammals.

The paper shows that LOTR1, an extracellular protease, is required for non-cell-autonomous positioning of Casparian Strip domains in plants, coordinating their formation across neighboring cells.

This paper demonstrates a laser-induced cell sorting technique that isolates and cultivates single microbial cells with viability, achieving varying recovery rates across different species.

The paper tests whether beta-diversity contributes to the latitudinal gradient in species richness by analyzing tree species data across East Asia.

This study identifies a rare case where closely related fungi produce structurally distinct beauveriolide analogs, challenging fungal chemotaxonomy and revealing insights into BGC evolution and virulence.

The paper analyzes structural and evolutionary features of cholesterol recognition sites in integral membrane proteins to distinguish specific from nonspecific interactions.

This study develops a network-based immunogenomics model to identify mutations affecting immune responses in cancer and suggests potential immunomodulatory drug candidates.

This study investigates the evolution, cross-species transmission, and origin of bat coronaviruses in China using sequence data and Bayesian analysis.

This study shows that inhibiting mitochondrial respiration in RPE cells alters intracellular and extracellular metabolites, revealing a metabolic signature of mitochondrial dysfunction.

This study analyzes indirect calorimetry data from thousands of mice to identify sources of metabolic variation and provides guidelines for designing and reporting metabolic experiments.

This study shows mosquito defensin enhances JEV infection by promoting virus adsorption and down-regulating an antiviral protein.

This study shows that CREB1 regulates colorectal cancer cell plasticity by controlling lncRNA CCAT1 and the NF-κB pathway through interactions with CBP/p300 and p65.

The paper uses single-cell RNA sequencing to analyze immature human thymocytes and identifies thymus seeding precursors and T-lineage developmental pathways.

This study examines risperidone-induced DNA methylation changes in first-episode schizophrenia patients and links them to neuroimaging and cognitive phenotypes.

This study identifies recurrent neoantigens in esophageal carcinoma using mutation data from multiple sources, highlighting potential targets for immunotherapy.

The paper constructs an adult human cell atlas from 84,363 cells across 15 organs, identifying 252 cell subtypes and revealing inter- and intra-organ heterogeneity.

This study shows that LIF alone can reprogram 2i/LIF cultured ESCs to hypermethylated ESCs, demonstrating DNA methylation's essential role in LIF-dependent reprogramming and self-renewal.

This study shows that USP21 knockout in Treg cells disrupts immune regulation during Schistosoma japonicum infection, promoting parasite survival and altering immune responses while reducing immune pathology.

This study shows that hnRNP-U is essential for physiological skeletal muscle hypertrophy, as its deficiency leads to muscle wasting due to impaired autophagy and anabolic resistance.

The paper identifies thousands of novel unannotated proteins in cancer that contribute to the MHC I immunopeptidome, expanding potential targets for immunotherapy.

The paper develops an in vitro vesicle formation assay to identify proteins involved in cargo sorting and trafficking, revealing novel regulators like FAM84B and PRRC1.

This paper identifies and characterizes a novel coronavirus (nCoV-2019) causing a human pneumonia outbreak, showing its close genetic relationship to bat coronaviruses and its use of the ACE2 receptor for cell entry.

This study isolates lymphovascular breast cancer cells using LCM and G&T-seq to identify three distinct clonal pathways associated with different survival outcomes and ribosomal protein downregulation as a poor prognosis marker.

This study identifies strain-level features of the mouse gut microbiota using metagenome-assembled genomes, revealing distinct genomic and functional characteristics compared to human gut microbes.

The paper assesses how gravel bar restoration in a dam-regulated river affects microbial community structure and functional diversity compared to undisturbed tributaries.

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

This study determines the cryoEM structure of α-synuclein fibrils with the E46K mutation, revealing a more stable and pathogenic fibril structure compared to wild-type.

This study identifies recurrent neoantigens in colorectal cancer using whole exome sequencing data from multiple cohorts, highlighting potential immunotherapy targets.

This study shows that TLR2 signaling reduces S. uberis infection severity by promoting mitochondrial reactive oxygen species production in mammary epithelial cells.