B. Sun

Integrin α6 upregulation in nucleus pulposus cell under high oxygen tension attenuates intervertebral disc degeneration

This study shows that high oxygen tension upregulates integrin α6 in nucleus pulposus cells, which protects against intervertebral disc degeneration by reducing apoptosis and oxidative stress.

Structural and immunological identification and antiviral infection experiment of the dominant cytotoxic T lymphocyte epitopes of the oncogenic Marek's disease virus

The paper identifies dominant cytotoxic T lymphocyte epitopes of Marek's disease virus, confirms their immunoprotective effects, and highlights key factors for effective antitumor immunity.

IRGM/Irgm1 Aggravates Progression of Atherosclerosis by Inducing Macrophage Apoptosis through the MAPK Signaling Pathway

This study shows IRGM/Irgm1 worsens atherosclerosis by causing macrophage apoptosis via the MAPK pathway, increasing plaque vulnerability and risk of rupture.

The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

This study reveals that the nuclear localization sequence of hnRNPA1 forms the core of amyloid fibrils and interacts with Kap{beta}2 to stabilize them, linking nucleo-cytoplasmic transport to neurodegeneration.

Activated Expression of Master Regulator MYB31 and of Capsaicinoid Biosynthesis Genes Results in Capsaicinoid Biosynthesis and Accumulation in the Pericarp of the Extremely Pungent Capsicum chinense

The paper shows that MYB31 activation and CBG expression in the pericarp of C. chinense leads to high capsaicinoid accumulation, explaining the extreme pungency of these peppers.

A comparison of Remdesivir versus Au22Glutathione18 in COVID-19 golden hamsters: a better therapeutic outcome of gold compound

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

Emergence of synchronized multicellular mechanosensing from spatiotemporal integration of heterogeneous single-cell information transfer

The paper quantifies how individual cell behaviors contribute to multicellular synchronization through information transfer in endothelial cell monolayers.

Structural determinants of calcium binding beyond the EF-hand binding site: A study of alpha parvalbumins

This study investigates the structural factors influencing calcium binding in alpha parvalbumins, finding that both local and non-local protein properties contribute to Ca2+ affinity and Mg2+ selectivity.

Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

Transcriptomic and Proteomic analysis of clear cell foci (CCF) in the human non-cirrhotic liver identifies several differentially expressed genes and proteins with functions in cancer cell biology and glycogen metabolism.

The paper identifies differentially expressed genes and proteins in liver clear cell foci (CCF) and finds that reduced expression of STBD1 and USP28 is unlikely to explain glycogen overload.

Co-localization and confinement of ecto-nucleotidases modulate extracellular adenosine nucleotide pools

This study uses reaction-diffusion simulations to show that confinement and charge effects in narrow extracellular spaces influence the kinetics of coupled nucleotidase reactions.

Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver

The paper identifies IL-24 as an anti-apoptotic factor in liver ER stress, showing its role in preventing cell death and its clinical relevance in acute liver failure.

Century long fertilization reduces stochasticity controlling grassland microbial community succession

This study examines how century-long fertilization affects microbial community succession and assembly mechanisms in grassland soils.

Functional arrays of human pluripotent stem cell-derived cardiac microtissues

This paper develops a 96-well platform of cardiac microtissues to measure contractile force for drug screening and tissue engineering.

Cation binding to SERCA

This study uses computational methods to analyze cation binding to SERCA, finding that Ca2+ is preferentially coordinated over Mg2+ and K+ at sites I and II, with Mg2+ acting as an inhibitor and K+ as an intermediate in the reaction cycle.

Seedling leaves allocate lower fractions of nitrogen to photosynthetic apparatus in nitrogen fixing trees (Dalbergia odorifera and Erythrophleum fordii) than in non-nitrogen fixing trees (Betula alnoides and Castanopsis hystrix) in subtropical China

The paper compares nitrogen allocation in leaves of nitrogen-fixing and non-nitrogen-fixing tree species, finding lower photosynthetic nitrogen use efficiency in nitrogen-fixing species due to reduced allocation to Rubisco and bioenergetics.

Multiplexed Profiling of Single-cell Extracellular Vesicles Secretion

This paper develops a platform to multiplex profile single-cell EV secretion, revealing heterogeneity in EV phenotypes and secretion patterns in OSCC cells.

Late B lymphocyte action in dysfunctional tissue repair following kidney injury and transplantation

The paper identifies a late B lymphocyte response linked to renal dysfunction and fibrosis following kidney injury and transplantation.

Helicase Promotes Replication Re-initiation from an RNA Transcript

This study shows that T7 helicase can restart DNA replication from an RNA transcript without replication restart proteins or primase.

Dual roles of electrostatic-steering and conformational dynamics in the binding of calcineurin’s intrinsically-disordered recognition domain to calmodulin

This study uses computational modeling to investigate how electrostatic interactions and conformational dynamics influence the binding of calcineurin’s disordered domain to calmodulin.